6YM4
| Crystal structure of BAY-297 with PIP4K2A | 分子名称: | (2~{R})-2-[[2-[4-(3-chloranyl-2-fluoranyl-phenyl)phenyl]-3-cyano-1,7-naphthyridin-4-yl]amino]butanamide, GLYCEROL, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | 著者 | Holton, S.J, Wortmann, L, Braeuer, N, Irlbacher, H, Weiske, J, Lechner, C, Meier, R, Puetter, V, Christ, C, ter Laak, T, Lienau, P, Lesche, R, Nicke, B, Bauser, M, Haegebarth, A, von Nussbaum, F, Mumberg, D, Lemos, C. | 登録日 | 2020-04-07 | 公開日 | 2021-04-14 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A. J.Med.Chem., 64, 2021
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6V9X
| Structure of TRPA1 modified by iodoacetamide, PMAL-C8 | 分子名称: | Transient receptor potential cation channel subfamily A member 1 | 著者 | Zhao, J, Lin King, J.V, Paulsen, C.E, Cheng, Y, Julius, D. | 登録日 | 2019-12-16 | 公開日 | 2020-05-06 | 最終更新日 | 2020-09-16 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Irritant-evoked activation and calcium modulation of the TRPA1 receptor. Nature, 585, 2020
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6VB0
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5A4P
| Structure of UBE2Z provides functional insight into specificity in the FAT10 conjugation machinery | 分子名称: | DI(HYDROXYETHYL)ETHER, MALONATE ION, UBIQUITIN-CONJUGATING ENZYME E2 Z | 著者 | Schelpe, J, Monte, D, Dewitte, F, Sixma, T.K, Rucktooa, P. | 登録日 | 2015-06-11 | 公開日 | 2015-11-18 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure of Ube2Z Provides Functional Insight Into Specificity in the Fat10 Conjugation Machinery J.Biol.Chem., 291, 2016
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6VB3
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5AIG
| Discovery and characterization of thermophilic limonene-1,2-epoxide hydrolases from hot spring metagenomic libraries. Tomsk-sample- Valpromide complex | 分子名称: | 2-PROPYLPENTANAMIDE, DIMETHYL SULFOXIDE, LIMONENE-1,2-EPOXIDE HYDROLASE | 著者 | Ferrandi, E, Sayer, C, Isupov, M.N, Annovazzi, C, Marchesi, C, Iacobone, G, Peng, X, Bonch-Osmolovskaya, E, Wohlgemuth, R, Littlechild, J.A, Montia, D. | 登録日 | 2015-02-13 | 公開日 | 2015-06-17 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.16 Å) | 主引用文献 | Discovery and Characterization of Thermophilic Limonene-1,2-Epoxide Hydrolases from Hot Spring Metagenomic Libraries FEBS J., 282, 2015
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5A2S
| Potent, selective and CNS-penetrant tetrasubstituted cyclopropane class IIa histone deacetylase (HDAC) inhibitors | 分子名称: | (1S,2S,3S)-1-fluoranyl-2-[4-(5-fluoranylpyrimidin-2-yl)phenyl]-N-oxidanyl-3-phenyl-cyclopropane-1-carboxamide, HISTONE DEACETYLASE 4, SODIUM ION, ... | 著者 | Luckhurst, C.A, Breccia, P, Stott, A.J, Aziz, O, Birch, H, Burli, R.W, Hughes, S, Jarvis, R.E, Lamers, M, Leonard, P, Matthews, K.L, McAllister, G, Pollack, S, Saville-Stones, E, Wishart, G, Yates, D, Dominguez, C. | 登録日 | 2015-05-22 | 公開日 | 2016-02-10 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Potent, Selective, and Cns-Penetrant Tetrasubstituted Cyclopropane Class Iia Histone Deacetylase (Hdac) Inhibitors. Acs Med.Chem.Lett., 7, 2016
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6YPI
| Structure of the engineered metallo-Diels-Alderase DA7 W16G,K58Q,L77R,T78R | 分子名称: | 3-[BENZYL(DIMETHYL)AMMONIO]PROPANE-1-SULFONATE, BENZOIC ACID, DA7 W16G,K58Q,L77R,T78R, ... | 著者 | Basler, S, Mori, T, Hilvert, D. | 登録日 | 2020-04-16 | 公開日 | 2021-04-28 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.479 Å) | 主引用文献 | Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold. Nat.Chem., 13, 2021
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5AJA
| Crystal structure of mandrill SAMHD1 (amino acid residues 1-114) bound to Vpx isolated from mandrill and human DCAF1 (amino acid residues 1058-1396) | 分子名称: | PROTEIN VPRBP, SAM DOMAIN AND HD DOMAIN-CONTAINING PROTEIN, VPX PROTEIN, ... | 著者 | Schwefel, D, Boucherit, V.C, Christodoulou, E, Walker, P.A, Stoye, J.P, Bishop, K.N, Taylor, I.A. | 登録日 | 2015-02-20 | 公開日 | 2015-04-22 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.649 Å) | 主引用文献 | Molecular Determinants for Recognition of Divergent Samhd1 Proteins by the Lentiviral Accessory Protein Vpx. Cell Host Microbe., 17, 2015
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6VAQ
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2X8S
| Crystal Structure of the Abn2 D171A mutant in complex with arabinotriose | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, ... | 著者 | deSanctis, D, Inacio, J.M, Lindley, P.F, de Sa-Nogueira, I, Bento, I. | 登録日 | 2010-03-11 | 公開日 | 2011-03-23 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | New Evidence for the Role of Calcium in the Glycosidase Reaction of Gh43 Arabinanases. FEBS J., 277, 2010
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5A3A
| Crystal structure of the ADP-ribosylating sirtuin (SirTM) from Streptococcus pyogenes (Apo form) | 分子名称: | 1,2-ETHANEDIOL, GLYCINE, SIR2 FAMILY PROTEIN, ... | 著者 | Rack, J.G.M, Morra, R, Barkauskaite, E, Kraehenbuehl, R, Ariza, A, Qu, Y, Ortmayer, M, Leidecker, O, Cameron, D.R, Matic, I, Peleg, A.Y, Leys, D, Traven, A, Ahel, I. | 登録日 | 2015-05-28 | 公開日 | 2015-07-29 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Identification of a Class of Protein Adp-Ribosylating Sirtuins in Microbial Pathogens. Mol.Cell, 59, 2015
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4N9W
| Crystal structure of phosphatidyl mannosyltransferase PimA | 分子名称: | 1,2-ETHANEDIOL, GDP-mannose-dependent alpha-(1-2)-phosphatidylinositol mannosyltransferase, GUANOSINE-5'-DIPHOSPHATE | 著者 | Giganti, D, Albesa-Jove, D, Bellinzoni, M, Guerin, M.E, Alzari, P.M. | 登録日 | 2013-10-21 | 公開日 | 2014-11-12 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Secondary structure reshuffling modulates glycosyltransferase function at the membrane. Nat.Chem.Biol., 11, 2015
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6VB2
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6VB5
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5AFB
| Crystal structure of the Latrophilin3 Lectin and Olfactomedin Domains | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GLYCEROL, ... | 著者 | Jackson, V.A, del Toro, D, Carrasquero, M, Roversi, P, Harlos, K, Klein, R, Seiradake, E. | 登録日 | 2015-01-21 | 公開日 | 2015-03-18 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | 主引用文献 | Structural Basis of Latrophilin-Flrt Interaction. Structure, 23, 2015
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5AII
| Discovery and characterization of thermophilic limonene-1,2-epoxide hydrolases from hot spring metagenomic libraries. CH55-sample-PEG complex | 分子名称: | 1,2-ETHANEDIOL, 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, ... | 著者 | Ferrandi, E, Sayer, C, Isupov, M.N, Annovazzi, C, Marchesi, C, Iacobone, G, Peng, X, Bonch-Osmolovskaya, E, Wohlgemuth, R, Littlechild, J.A, Montia, D. | 登録日 | 2015-02-13 | 公開日 | 2015-06-17 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Discovery and Characterization of Thermophilic Limonene-1,2-Epoxide Hydrolases from Hot Spring Metagenomic Libraries FEBS J., 282, 2015
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6VHL
| Paired Helical Filament from Alzheimer's Disease Human Brain Tissue | 分子名称: | GLYCINE, Microtubule-associated protein tau | 著者 | Arakhamia, T, Lee, C.E, Carlomagno, Y, Duong, D.M, Kundinger, S.R, Wang, K, Williams, D, DeTure, M, Dickson, D.W, Cook, C.N, Seyfried, N.T, Petrucelli, L, Fitzpatrick, A.W.P. | 登録日 | 2020-01-10 | 公開日 | 2020-03-04 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains. Cell, 180, 2020
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1PJN
| Mouse Importin alpha-bipartite NLS N1N2 from Xenopus laevis phosphoprotein Complex | 分子名称: | Histone-binding protein N1/N2, Importin alpha-2 subunit | 著者 | Fontes, M.R.M, Teh, T, Jans, D, Brinkworth, R.I, Kobe, B. | 登録日 | 2003-06-03 | 公開日 | 2003-08-19 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha J.Biol.Chem., 278, 2003
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1PJM
| Mouse Importin alpha-bipartite NLS from human retinoblastoma protein Complex | 分子名称: | Importin alpha-2 subunit, Retinoblastoma-associated protein | 著者 | Fontes, M.R.M, Teh, T, Jans, D, Brinkworth, R.I, Kobe, B. | 登録日 | 2003-06-03 | 公開日 | 2003-08-19 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha J.Biol.Chem., 278, 2003
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5AH0
| STRUCTURE OF LIPASE 1 FROM PELOSINUS FERMENTANS | 分子名称: | DI(HYDROXYETHYL)ETHER, LIPASE, POTASSIUM ION, ... | 著者 | Hromic, A, Gruber, K, Biundo, A, Ribitsch, D, Quartinello, F, Perz, V, Arrell, M.S, Kalman, F, Guebitz, G.M. | 登録日 | 2015-02-04 | 公開日 | 2015-11-04 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Characterization of a Poly(Butylene Adipate-Co-Terephthalate)-Hydrolyzing Lipase from Pelosinus Fermentans. Appl.Microbiol.Biotechnol., 100, 2016
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6YA9
| Crystal structure of rsGCaMP in the ON state (non-illuminated) | 分子名称: | CALCIUM ION, rsCGaMP | 著者 | Janowski, R, Fuenzalida-Werner, J.P, Mishra, K, Stiel, A.C, Niessing, D. | 登録日 | 2020-03-11 | 公開日 | 2021-10-06 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Genetically encoded photo-switchable molecular sensors for optoacoustic and super-resolution imaging. Nat.Biotechnol., 2021
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6UZP
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2X8T
| Crystal Structure of the Abn2 H318A mutant | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, ... | 著者 | deSanctis, D, Inacio, J.M, Lindley, P.F, de Sa-Nogueira, I, Bento, I. | 登録日 | 2010-03-11 | 公開日 | 2011-03-23 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | New Evidence for the Role of Calcium in the Glycosidase Reaction of Gh43 Arabinanases. FEBS J., 277, 2010
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6UZV
| The structure of a red shifted photosystem I complex | 分子名称: | 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, BETA-CAROTENE, ... | 著者 | Toporik, H, Williams, D, Chiu, P.L, Mazor, Y. | 登録日 | 2019-11-15 | 公開日 | 2020-09-16 | 最終更新日 | 2020-11-04 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | The structure of a red-shifted photosystem I reveals a red site in the core antenna. Nat Commun, 11, 2020
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