5AJA

Crystal structure of mandrill SAMHD1 (amino acid residues 1-114) bound to Vpx isolated from mandrill and human DCAF1 (amino acid residues 1058-1396)

Summary for 5AJA

Entry DOI	10.2210/pdb5aja/pdb
Descriptor	PROTEIN VPRBP, VPX PROTEIN, SAM DOMAIN AND HD DOMAIN-CONTAINING PROTEIN, ... (5 entities in total)
Functional Keywords	viral protein, siv, accessory protein, retroviral restriction factor, ubiquitylation, proteasomal degradation
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Cytoplasm: Q9Y4B6
Total number of polymer chains	3
Total formula weight	65993.56
Authors	Schwefel, D.,Boucherit, V.C.,Christodoulou, E.,Walker, P.A.,Stoye, J.P.,Bishop, K.N.,Taylor, I.A. (deposition date: 2015-02-20, release date: 2015-04-22, Last modification date: 2024-01-10)
Primary citation	Schwefel, D.,Boucherit, V.C.,Christodoulou, E.,Walker, P.A.,Stoye, J.P.,Bishop, K.N.,Taylor, I.A. Molecular Determinants for Recognition of Divergent Samhd1 Proteins by the Lentiviral Accessory Protein Vpx. Cell Host Microbe., 17:489-, 2015 Cited by PubMed: 25856754 DOI: 10.1016/J.CHOM.2015.03.004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.649 Å)

Structure validation