5AJA
Crystal structure of mandrill SAMHD1 (amino acid residues 1-114) bound to Vpx isolated from mandrill and human DCAF1 (amino acid residues 1058-1396)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | PROTEIN VPRBP | polymer | 361 | 41073.1 | 1 | UniProt (Q9Y4B6) | HOMO SAPIENS (HUMAN) | DCAF1, DDB1- AND CUL4-ASSOCIATED FACTOR 1, HIV-1 VPR-BINDING PROTEIN, VPRBP, SERINE/THREONINE-PROTEIN KINASE VPRBP, VPR-INTERACTING PROTEIN |
| 2 | B (B) | VPX PROTEIN | polymer | 102 | 11940.6 | 1 | UniProt (Q7ZB17) Pfam (PF00522) | SIMIAN IMMUNODEFICIENCY VIRUS | |
| 3 | C (C) | SAM DOMAIN AND HD DOMAIN-CONTAINING PROTEIN | polymer | 117 | 12914.4 | 1 | UniProt (H6WEA4) Pfam (PF07647) | MANDRILLUS SPHINX (MANDRILL) | SAMHD1, SAM DOMAIN AND HD DOMAIN-CONTAINING PROTEIN 1 |
| 4 | D (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
A: 1058 - 1396 (UniProt: Q9Y4B6)
B: 1 - 99 (UniProt: Q7ZB17)
C: 1 - 114 (UniProt: H6WEA4)
| PDB | External Database | Details |
|---|---|---|
| Met 1057 | - | expression tag |
| Glu 1397 | - | expression tag |
| Leu 1398 | - | expression tag |
| Ala 1399 | - | expression tag |
| Leu 1400 | - | expression tag |
| Val 1401 | - | expression tag |
| Pro 1402 | - | expression tag |
| Arg 1403 | - | expression tag |
| Gly 1404 | - | expression tag |
| Ser 1405 | - | expression tag |
| Ser 1406 | - | expression tag |
| Ala 1407 | - | expression tag |
| His 1408 | - | expression tag |
| His 1409 | - | expression tag |
| His 1410 | - | expression tag |
| His 1411 | - | expression tag |
| His 1412 | - | expression tag |
| His 1413 | - | expression tag |
| His 1414 | - | expression tag |
| His 1415 | - | expression tag |
| His 1416 | - | expression tag |
| His 1417 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Pro -1 | - | expression tag |
| Gly 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Pro -1 | - | expression tag |
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 65928.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 65.4 | |
| All* | Total formula weight | 65993.6 |
