6XWK
| Crystal structure of Phormidium rubidum phycocyanin | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, IMIDAZOLE, ... | 著者 | Sonani, R.R, Roszak, A.W, Cogdell, R.J, Madamwar, D, Liu, H, Gross, M.L, Blankenship, R.E. | 登録日 | 2020-01-23 | 公開日 | 2020-04-29 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.17 Å) | 主引用文献 | Revisiting high-resolution crystal structure of Phormidium rubidum phycocyanin. Photosyn. Res., 144, 2020
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6X9H
| Molecular mechanism and structural basis of small-molecule modulation of acid-sensing ion channel 1 (ASIC1) | 分子名称: | 2-[4-(3,4-dimethoxyphenoxy)phenyl]-1H-benzimidazole-6-carboximidamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1, ... | 著者 | Liu, Y, Ma, J, DesJarlais, R.L, Hagan, R, Rech, J, Lin, D, Liu, C, Miller, R, Schoellerman, J, Luo, J, Letavic, M, Grasberger, B, Maher, M. | 登録日 | 2020-06-02 | 公開日 | 2020-12-30 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | 主引用文献 | Molecular mechanism and structural basis of small-molecule modulation of the gating of acid-sensing ion channel 1. Commun Biol, 4, 2021
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5ET5
| Human muscle fructose-1,6-bisphosphatase in active R-state | 分子名称: | Fructose-1,6-bisphosphatase isozyme 2 | 著者 | Barciszewski, J, Wisniewski, J, Kolodziejczyk, R, Dzugaj, A, Jaskolski, M, Rakus, D. | 登録日 | 2015-11-17 | 公開日 | 2016-04-13 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | T-to-R switch of muscle fructose-1,6-bisphosphatase involves fundamental changes of secondary and quaternary structure. Acta Crystallogr D Struct Biol, 72, 2016
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5ET8
| Human muscle fructose-1,6-bisphosphatase in active R-state in complex with fructose-6-phosphate | 分子名称: | 6-O-phosphono-beta-D-fructofuranose, Fructose-1,6-bisphosphatase isozyme 2 | 著者 | Barciszewski, J, Wisniewski, J, Kolodziejczyk, R, Dzugaj, A, Jaskolski, M, Rakus, D. | 登録日 | 2015-11-17 | 公開日 | 2016-11-23 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | T-to-R switch of muscle FBPase involves extreme changes of secondary and quaternary structure To Be Published
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5ET6
| Human muscle fructose-1,6-bisphosphatase in inactive T-state in complex with AMP | 分子名称: | ADENOSINE MONOPHOSPHATE, Fructose-1,6-bisphosphatase isozyme 2 | 著者 | Barciszewski, J, Wisniewski, J, Kolodziejczyk, R, Dzugaj, A, Jaskolski, M, Rakus, D. | 登録日 | 2015-11-17 | 公開日 | 2016-04-13 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.845 Å) | 主引用文献 | T-to-R switch of muscle fructose-1,6-bisphosphatase involves fundamental changes of secondary and quaternary structure. Acta Crystallogr D Struct Biol, 72, 2016
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5ET7
| Human muscle fructose-1,6-bisphosphatase in inactive T-state | 分子名称: | Fructose-1,6-bisphosphatase isozyme 2 | 著者 | Barciszewski, J, Wisniewski, J, Kolodziejczyk, R, Dzugaj, A, Jaskolski, M, Rakus, D. | 登録日 | 2015-11-17 | 公開日 | 2016-04-13 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.989 Å) | 主引用文献 | T-to-R switch of muscle fructose-1,6-bisphosphatase involves fundamental changes of secondary and quaternary structure. Acta Crystallogr D Struct Biol, 72, 2016
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6XG8
| ISCth4 transposase, pre-cleaved complex, PCC | 分子名称: | DNA (26-MER), Mutator family transposase | 著者 | Kosek, D, Dyda, F. | 登録日 | 2020-06-17 | 公開日 | 2020-10-14 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Structures of ISCth4 transpososomes reveal the role of asymmetry in copy-out/paste-in DNA transposition. Embo J., 40, 2021
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5F6D
| Crystal structure of Ubc9 (K48A/K49A/E54A) complexed with Fragment 6 | 分子名称: | 6~{H}-benzo[c][1,2]benzothiazine 5,5-dioxide, SUMO-conjugating enzyme UBC9 | 著者 | Lountos, G.T, Hewitt, W.M, Zlotkowski, K, Dahlhauser, S, Saunders, L.B, Needle, D, Tropea, J.E, Zhan, C, Wei, G, Ma, B, Nussinov, R, Schneekloth, J.S.Jr, Waugh, D.S. | 登録日 | 2015-12-05 | 公開日 | 2016-04-27 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.553 Å) | 主引用文献 | Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9. Angew.Chem.Int.Ed.Engl., 55, 2016
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6XKT
| R. capsulatus cyt bc1 with both FeS proteins in c position (CIII2 c-c) | 分子名称: | Cytochrome b, Cytochrome c1, FE2/S2 (INORGANIC) CLUSTER, ... | 著者 | Steimle, S, Van Eeuwen, T, Ozturk, Y, Kim, H.J, Braitbard, M, Selamoglu, N, Garcia, B.A, Schneidman-Duhovny, D, Murakami, K, Daldal, F. | 登録日 | 2020-06-27 | 公開日 | 2020-12-30 | 最終更新日 | 2021-03-03 | 実験手法 | ELECTRON MICROSCOPY (3.75 Å) | 主引用文献 | Cryo-EM structures of engineered active bc 1 -cbb 3 type CIII 2 CIV super-complexes and electronic communication between the complexes. Nat Commun, 12, 2021
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6XLW
| Crystal structure of U2AF65 bound to AdML splice site sequence | 分子名称: | DI(HYDROXYETHYL)ETHER, DNA/RNA (5'-R(P*UP*UP*(UD)P*UP*U)-D(P*(BRU))-R(P*CP*C)-3'), GLYCEROL, ... | 著者 | Maji, D, Jenkins, J.L, Kielkopf, C.L. | 登録日 | 2020-06-29 | 公開日 | 2020-10-07 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing. J.Biol.Chem., 295, 2020
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5HX1
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6XVC
| CRYSTAL STRUCTURE OF BRD4-BD1 WITH COMPOUND 1 | 分子名称: | (4~{R})-4-[(1~{R})-1-[7-(3-methyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)quinolin-5-yl]oxyethyl]pyrrolidin-2-one, 1,2-ETHANEDIOL, Bromodomain-containing protein 4 | 著者 | Bader, G, Kessler, D, Wolkerstorfer, B. | 登録日 | 2020-01-21 | 公開日 | 2020-07-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.098 Å) | 主引用文献 | PI by NMR: Probing CH-pi Interactions in Protein-Ligand Complexes by NMR Spectroscopy. Angew.Chem.Int.Ed.Engl., 59, 2020
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7L0N
| Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity | 分子名称: | 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | 著者 | Snell, G, Czudnochowski, N, Dillen, J, Nix, J.C, Croll, T.I, Corti, D. | 登録日 | 2020-12-11 | 公開日 | 2021-02-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | 主引用文献 | Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity. Cell, 184, 2021
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5H73
| Crystal structure of human DHODH with 18F | 分子名称: | ACETATE ION, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | 著者 | Huang, J, Wu, D. | 登録日 | 2016-11-16 | 公開日 | 2017-07-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Crystal structure of human DHODH with 18F at 1.58 Angstroms resolution To Be Published
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6MJ5
| Crystal structure of Tdp1 catalytic domain in complex with compound XZ519 | 分子名称: | 1,2-ETHANEDIOL, 4-hydroxy-8-nitroquinoline-3-carboxylic acid, Tyrosyl-DNA phosphodiesterase 1 | 著者 | Lountos, G.T, Zhao, X.Z, Kiselev, E, Tropea, J.E, Needle, D, Burke Jr, T.R, Pommier, Y, Waugh, D.S. | 登録日 | 2018-09-20 | 公開日 | 2019-07-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.853 Å) | 主引用文献 | Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening. Nucleic Acids Res., 47, 2019
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6MJP
| LptB(E163Q)FGC from Vibrio cholerae | 分子名称: | 2-(2-ETHOXYETHOXY)ETHANOL, 6-cyclohexylhexyl beta-D-glucopyranoside, ABC transporter ATP-binding protein, ... | 著者 | Owens, T.W, Kahne, D, Kruse, A.C. | 登録日 | 2018-09-21 | 公開日 | 2019-03-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Structural basis of unidirectional export of lipopolysaccharide to the cell surface. Nature, 567, 2019
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1PTY
| CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH TWO PHOSPHOTYROSINE MOLECULES | 分子名称: | MAGNESIUM ION, O-PHOSPHOTYROSINE, PROTEIN TYROSINE PHOSPHATASE 1B | 著者 | Zhao, Y, Puius, Y.A, Sullivan, M, Lawrence, D, Almo, S.C, Zhang, Z.-Y. | 登録日 | 1997-01-16 | 公開日 | 1998-01-21 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design. Proc.Natl.Acad.Sci.USA, 94, 1997
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5H9T
| Crystal structure of native NalD at resolution of 2.9, the secondary repressor of MexAB-OprM multidrug efflux pump in Pseudomonas aeruginosa | 分子名称: | NalD | 著者 | Chen, W.Z, Wang, D, Huang, S.Q, Hu, Q.Y, Liu, X.C, Gan, J.H, Chen, H. | 登録日 | 2015-12-29 | 公開日 | 2016-04-20 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | 主引用文献 | Novobiocin binding to NalD induces the expression of the MexAB-OprM pump in Pseudomonas aeruginosa. Mol. Microbiol., 100, 2016
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6YL8
| Crystal structure of YTHDC1 with compound DHU_DC1_011 | 分子名称: | (2~{R},5~{S})-2-(2-chlorophenyl)-5-methyl-morpholine, SULFATE ION, YTHDC1 | 著者 | Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. | 登録日 | 2020-04-06 | 公開日 | 2020-07-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
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4NC9
| Crystal structure of phosphatidyl mannosyltransferase PimA | 分子名称: | GDP-mannose-dependent alpha-(1-2)-phosphatidylinositol mannosyltransferase | 著者 | Giganti, D, Albesa-Jove, D, Bellinzoni, M, Guerin, M.E, Alzari, P.M. | 登録日 | 2013-10-24 | 公開日 | 2014-11-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.192 Å) | 主引用文献 | Secondary structure reshuffling modulates glycosyltransferase function at the membrane. Nat.Chem.Biol., 11, 2015
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6YLV
| Translation initiation factor 4E in complex with 4-Cl-Bn7GpppG mRNA 5' cap analog | 分子名称: | 4-Cl-Bn7GpppG mRNA 5' cap analog, Eukaryotic translation initiation factor 4E, GLYCEROL | 著者 | Kubacka, D, Wojcik, R, Baranowski, M.R, Kowalska, J, Jemielity, J. | 登録日 | 2020-04-07 | 公開日 | 2020-06-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.66005659 Å) | 主引用文献 | Novel N7-Arylmethyl Substituted Dinucleotide mRNA 5' cap Analogs: Synthesis and Evaluation as Modulators of Translation. Pharmaceutics, 13, 2021
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5HCI
| GPN-loop GTPase Npa3 in complex with GDP | 分子名称: | GLYCEROL, GPN-loop GTPase 1, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Niesser, J, Wagner, F.R, Kostrewa, D, Muehlbacher, W, Cramer, P. | 登録日 | 2016-01-04 | 公開日 | 2016-01-20 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure of GPN-Loop GTPase Npa3 and Implications for RNA Polymerase II Assembly. Mol.Cell.Biol., 36, 2015
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5HD4
| Dissecting Therapeutic Resistance to ERK Inhibition Rat Wild Type SCH772984 in complex with (3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)-N-[3-(pyridin-4-yl)-2H-indazol-5-yl]pyrrolidine-3-carboxamide | 分子名称: | (3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)-N-[3-(pyridin-4-yl)-2H-indazol-5-yl]pyrrolidine-3-carboxamide, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ... | 著者 | Jha, S, Morris, E.J, Hruza, A, Mansueto, M.S, Schroeder, G, Arbanas, J, McMasters, D, Restaino, C.R, Dayananth, R, Black, S, Elsen, N.L, Mannarino, A, Cooper, A, Fawell, S, Zawel, L, Jayaraman, L, Samatar, A.A. | 登録日 | 2016-01-04 | 公開日 | 2016-02-24 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Dissecting Therapeutic Resistance to ERK Inhibition. Mol.Cancer Ther., 15, 2016
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6YNO
| Crystal structure of YTHDC1 with compound DHU_DC1_139 | 分子名称: | 6-[[methyl-[(1-phenylpyrazol-3-yl)methyl]amino]methyl]-1~{H}-pyrimidine-2,4-dione, SULFATE ION, YTHDC1 | 著者 | Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. | 登録日 | 2020-04-14 | 公開日 | 2020-07-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Atomistic and Thermodynamic Analysis of N6-Methyladenosine (m 6 A) Recognition by the Reader Domain of YTHDC1. J Chem Theory Comput, 17, 2021
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4NE6
| Human MHF1-MHF2 complex | 分子名称: | Centromere protein S, Centromere protein X | 著者 | Zhao, Q, Saro, D, Sachpatzidis, A, Sung, P, Xiong, Y. | 登録日 | 2013-10-28 | 公開日 | 2013-12-25 | 最終更新日 | 2014-02-12 | 実験手法 | X-RAY DIFFRACTION (2.1001 Å) | 主引用文献 | The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes. Nat Commun, 5, 2014
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