6X9H

Molecular mechanism and structural basis of small-molecule modulation of acid-sensing ion channel 1 (ASIC1)

Summary for 6X9H

Entry DOI	10.2210/pdb6x9h/pdb
Descriptor	Acid-sensing ion channel 1, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-[4-(3,4-dimethoxyphenoxy)phenyl]-1H-benzimidazole-6-carboximidamide, ... (4 entities in total)
Functional Keywords	asic1, modulation, membrane protein, transport protein
Biological source	Gallus gallus (Chicken)
Total number of polymer chains	3
Total formula weight	152314.13
Authors	Liu, Y.,Ma, J.,DesJarlais, R.L.,Hagan, R.,Rech, J.,Lin, D.,Liu, C.,Miller, R.,Schoellerman, J.,Luo, J.,Letavic, M.,Grasberger, B.,Maher, M. (deposition date: 2020-06-02, release date: 2020-12-30, Last modification date: 2023-10-18)
Primary citation	Liu, Y.,Ma, J.,DesJarlais, R.L.,Hagan, R.,Rech, J.,Lin, D.,Liu, C.,Miller, R.,Schoellerman, J.,Luo, J.,Letavic, M.,Grasberger, B.,Maher, M. Molecular mechanism and structural basis of small-molecule modulation of the gating of acid-sensing ion channel 1. Commun Biol, 4:174-174, 2021 Cited by PubMed: 33564124 DOI: 10.1038/s42003-021-01678-1 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.01 Å)

Structure validation