6X9H
Molecular mechanism and structural basis of small-molecule modulation of acid-sensing ion channel 1 (ASIC1)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005272 | molecular_function | sodium channel activity |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0015280 | molecular_function | ligand-gated sodium channel activity |
| A | 0016020 | cellular_component | membrane |
| B | 0005272 | molecular_function | sodium channel activity |
| B | 0006814 | biological_process | sodium ion transport |
| B | 0015280 | molecular_function | ligand-gated sodium channel activity |
| B | 0016020 | cellular_component | membrane |
| C | 0005272 | molecular_function | sodium channel activity |
| C | 0006814 | biological_process | sodium ion transport |
| C | 0015280 | molecular_function | ligand-gated sodium channel activity |
| C | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS01206 |
| Number of Residues | 21 |
| Details | ASC Amiloride-sensitive sodium channels signature. YsiTaCridCeTryLVenCnC |
| Chain | Residue | Details |
| A | TYR304-CYS324 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 63 |
| Details | TRANSMEM: Helical => ECO:0000305|PubMed:24507937, ECO:0007744|PDB:4NTW |
| Chain | Residue | Details |
| A | CYS50-LEU71 | |
| B | CYS50-LEU71 | |
| C | CYS50-LEU71 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1056 |
| Details | TOPO_DOM: Extracellular => ECO:0000305|PubMed:24507937, ECO:0007744|PDB:4NTW |
| Chain | Residue | Details |
| A | TYR72-ALA424 | |
| B | TYR72-ALA424 | |
| C | TYR72-ALA424 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 87 |
| Details | TRANSMEM: Discontinuously helical => ECO:0000305|PubMed:24507937, ECO:0007744|PDB:4NTW |
| Chain | Residue | Details |
| A | TYR425-ASP454 | |
| B | TYR425-ASP454 | |
| C | TYR425-ASP454 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | SITE: Involved in channel desensitization; the process by which the channel becomes unresponsive to proton stimulation => ECO:0000269|PubMed:22842900 |
| Chain | Residue | Details |
| A | GLU80 | |
| B | GLU80 | |
| C | GLU80 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | SITE: Involved in proton-dependent gating => ECO:0000250|UniProtKB:P78348 |
| Chain | Residue | Details |
| A | ASP356 | |
| B | ASP356 | |
| C | ASP356 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17882215, ECO:0000269|PubMed:22760635, ECO:0000269|PubMed:22842900, ECO:0007744|PDB:2QTS |
| Chain | Residue | Details |
| A | ASN367 | |
| A | ASN394 | |
| B | ASN367 | |
| B | ASN394 | |
| C | ASN367 | |
| C | ASN394 |
