6XVC

CRYSTAL STRUCTURE OF BRD4-BD1 WITH COMPOUND 1

Summary for 6XVC

Entry DOI	10.2210/pdb6xvc/pdb
Related	6XUZ 6XV3 6XV7
Descriptor	Bromodomain-containing protein 4, 1,2-ETHANEDIOL, (4~{R})-4-[(1~{R})-1-[7-(3-methyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)quinolin-5-yl]oxyethyl]pyrrolidin-2-one, ... (4 entities in total)
Functional Keywords	bromodomain, inhibitor, complex, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	15610.95
Authors	Bader, G.,Kessler, D.,Wolkerstorfer, B. (deposition date: 2020-01-21, release date: 2020-07-08, Last modification date: 2024-01-24)
Primary citation	Platzer, G.,Mayer, M.,Beier, A.,Bruschweiler, S.,Fuchs, J.E.,Engelhardt, H.,Geist, L.,Bader, G.,Schorghuber, J.,Lichtenecker, R.,Wolkerstorfer, B.,Kessler, D.,McConnell, D.B.,Konrat, R. PI by NMR: Probing CH-pi Interactions in Protein-Ligand Complexes by NMR Spectroscopy. Angew.Chem.Int.Ed.Engl., 59:14861-14868, 2020 Cited by PubMed: 32421895 DOI: 10.1002/anie.202003732 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.098 Å)

Structure validation