6XUZ
CRYSTAL STRUCTURE OF BRD4-BD1 WITH COMPOUND 4
Summary for 6XUZ
Entry DOI | 10.2210/pdb6xuz/pdb |
Descriptor | Bromodomain-containing protein 4, 6-[1-[(2~{S})-1-methoxypropan-2-yl]-6-[(3~{S})-3-methylmorpholin-4-yl]imidazo[4,5-c]pyridin-2-yl]-3-methyl-~{N}-propan-2-yl-[1,2,4]triazolo[4,3-a]pyrazin-8-amine (3 entities in total) |
Functional Keywords | bromodomain, inhibitor, complex, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 15578.96 |
Authors | Bader, G.,Kessler, D.,Wolkerstorfer, B. (deposition date: 2020-01-21, release date: 2020-07-08, Last modification date: 2024-01-24) |
Primary citation | Platzer, G.,Mayer, M.,Beier, A.,Bruschweiler, S.,Fuchs, J.E.,Engelhardt, H.,Geist, L.,Bader, G.,Schorghuber, J.,Lichtenecker, R.,Wolkerstorfer, B.,Kessler, D.,McConnell, D.B.,Konrat, R. PI by NMR: Probing CH-pi Interactions in Protein-Ligand Complexes by NMR Spectroscopy. Angew.Chem.Int.Ed.Engl., 59:14861-14868, 2020 Cited by PubMed: 32421895DOI: 10.1002/anie.202003732 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.07 Å) |
Structure validation
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