7L0N

Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity

Summary for 7L0N

• Entry DOI: 10.2210/pdb7l0n/pdb
• Descriptor: Monoclonal antibody S309 Fab light chain, SULFATE ION, SODIUM ION, ... (17 entities in total)
• Functional Keywords: covid-19, sars-cov-2, variant rbd, viral protein-receptor complex, viral protein, viral protein-hydrolase complex, viral protein/hydrolase
• Biological source: Homo sapiens; More
• Total number of polymer chains: 12
• Total formula weight: 380023.63

Authors

Snell, G.,Czudnochowski, N.,Dillen, J.,Nix, J.C.,Croll, T.I.,Corti, D. (deposition date: 2020-12-11, release date: 2021-02-17, Last modification date: 2023-10-18)

• Primary citation: Thomson, E.C.,Rosen, L.E.,Shepherd, J.G.,Spreafico, R.,da Silva Filipe, A.,Wojcechowskyj, J.A.,Davis, C.,Piccoli, L.,Pascall, D.J.,Dillen, J.,Lytras, S.,Czudnochowski, N.,Shah, R.,Meury, M.,Jesudason, N.,De Marco, A.,Li, K.,Bassi, J.,O'Toole, A.,Pinto, D.,Colquhoun, R.M.,Culap, K.,Jackson, B.,Zatta, F.,Rambaut, A.,Jaconi, S.,Sreenu, V.B.,Nix, J.,Zhang, I.,Jarrett, R.F.,Glass, W.G.,Beltramello, M.,Nomikou, K.,Pizzuto, M.,Tong, L.,Cameroni, E.,Croll, T.I.,Johnson, N.,Di Iulio, J.,Wickenhagen, A.,Ceschi, A.,Harbison, A.M.,Mair, D.,Ferrari, P.,Smollett, K.,Sallusto, F.,Carmichael, S.,Garzoni, C.,Nichols, J.,Galli, M.,Hughes, J.,Riva, A.,Ho, A.,Schiuma, M.,Semple, M.G.,Openshaw, P.J.M.,Fadda, E.,Baillie, J.K.,Chodera, J.D.,Rihn, S.J.,Lycett, S.J.,Virgin, H.W.,Telenti, A.,Corti, D.,Robertson, D.L.,Snell, G.; Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity.; Cell, 184:1171-1187.e20, 2021; PubMed: 33621484; DOI: 10.1016/j.cell.2021.01.037

Experimental method

X-RAY DIFFRACTION (2.78 Å)