7L0N
Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B, D | Monoclonal antibody S309 Fab light chain | polymer | 214 | 23204.7 | 2 | Homo sapiens | ||
| 2 | A, C | Monoclonal antibody S309 Fab heavy chain | polymer | 230 | 24573.5 | 2 | Homo sapiens | ||
| 3 | L, N | Monoclonal antibody S304 Fab light chain | polymer | 215 | 23369.9 | 2 | Homo sapiens | ||
| 4 | H, M | Monoclonal antibody S304 Fab heavy chain | polymer | 223 | 23729.4 | 2 | Homo sapiens | ||
| 5 | E, F | Angiotensin-converting enzyme 2 | polymer | 597 | 69153.7 | 2 | UniProt (Q9BYF1) Pfam (PF01401) In PDB | Homo sapiens (Human) | ACE-related carboxypeptidase,Angiotensin-converting enzyme homolog,ACEH,Metalloprotease MPROT15 |
| 6 | R, S | Spike protein S1 | polymer | 204 | 22963.9 | 2 | UniProt (P0DTC2) Pfam (PF09408) In PDB | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | S glycoprotein,E2,Peplomer protein,Spike glycoprotein |
| 7 | G | alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1057.0 | 1 | In PDB GlyTouCan (G52146XU) | |||
| 8 | I | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 894.8 | 1 | In PDB GlyTouCan (G00395TQ) | |||
| 9 | H, F, N, M, R... | CHLORIDE ION | non-polymer | 35.5 | 27 | Chemie (CL) | |||
| 10 | N, L | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 11 | F, R, H | SODIUM ION | non-polymer | 23.0 | 6 | Chemie (NA) | |||
| 12 | H | 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE | non-polymer | 178.2 | 1 | Chemie (PG5) | |||
| 13 | N | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 14 | E, F | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 15 | E, F | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 9 | Chemie (NAG) | |||
| 16 | S, E | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 2 | Chemie (PGE) | |||
| 17 | water | water | 18.0 | 232 | Chemie (HOH) |
Sequence modifications
R, S: 328 - 531 (UniProt: P0DTC2)
| PDB | External Database | Details |
|---|---|---|
| Lys 439 | Asn 439 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 373990.1 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1951.8 | |
| Non-Polymers* | Number of molecules | 50 |
| Total formula weight | 4081.8 | |
| All* | Total formula weight | 380023.6 |
