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5HD4

Dissecting Therapeutic Resistance to ERK Inhibition Rat Wild Type SCH772984 in complex with (3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)-N-[3-(pyridin-4-yl)-2H-indazol-5-yl]pyrrolidine-3-carboxamide

Summary for 5HD4
Entry DOI10.2210/pdb5hd4/pdb
Related5HD7
DescriptorMitogen-activated protein kinase 1, (3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)-N-[3-(pyridin-4-yl)-2H-indazol-5-yl]pyrrolidine-3-carboxamide, SULFATE ION, ... (6 entities in total)
Functional Keywordstransferase, serine/threonine-protein kinase, map kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceRattus norvegicus (Rat)
Cellular locationCytoplasm, cytoskeleton, spindle : P63086
Total number of polymer chains1
Total formula weight43456.86
Authors
Primary citationJha, S.,Morris, E.J.,Hruza, A.,Mansueto, M.S.,Schroeder, G.K.,Arbanas, J.,McMasters, D.,Restaino, C.R.,Dayananth, P.,Black, S.,Elsen, N.L.,Mannarino, A.,Cooper, A.,Fawell, S.,Zawel, L.,Jayaraman, L.,Samatar, A.A.
Dissecting Therapeutic Resistance to ERK Inhibition.
Mol.Cancer Ther., 15:548-559, 2016
Cited by
PubMed: 26832798
DOI: 10.1158/1535-7163.MCT-15-0172
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.45 Å)
Structure validation

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