4YDU
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![BU of 4ydu by Molmil](/molmil-images/mine/4ydu) | Crystal structure of E. coli YgjD-YeaZ heterodimer in complex with ADP | Descriptor: | ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, FE (III) ION, ... | Authors: | Zhang, W, Collinet, B, Perrochia, L, Durand, D, Van Tilbeurgh, H. | Deposit date: | 2015-02-23 | Release date: | 2015-03-04 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | The ATP-mediated formation of the YgjD-YeaZ-YjeE complex is required for the biosynthesis of tRNA t6A in Escherichia coli. Nucleic Acids Res., 43, 2015
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3I2T
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![BU of 3i2t by Molmil](/molmil-images/mine/3i2t) | Crystal structure of the unliganded Drosophila Epidermal Growth Factor Receptor ectodomain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, ... | Authors: | Alvarado, D, Klein, D.E, Lemmon, M.A. | Deposit date: | 2009-06-29 | Release date: | 2009-09-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor. Nature, 461, 2009
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5T68
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![BU of 5t68 by Molmil](/molmil-images/mine/5t68) | Crystal structure of Syk catalytic domain in complex with a furo[3,2-d]pyrimidine | Descriptor: | N~4~-cyclopropyl-N~2~-(3-methyl-1H-indazol-6-yl)furo[3,2-d]pyrimidine-2,4-diamine, Tyrosine-protein kinase SYK | Authors: | Argiriadi, M.A, Hoemann, M, Wilson, N, Banach, D, Burchat, A, Calderwood, D, Clapham, B, Cox, P, Duignan, D.B, Konopacki, D, Somal, G, Vasudevan, A. | Deposit date: | 2016-09-01 | Release date: | 2016-10-26 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.93 Å) | Cite: | Synthesis and optimization of furano[3,2-d]pyrimidines as selective spleen tyrosine kinase (Syk) inhibitors. Bioorg. Med. Chem. Lett., 26, 2016
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7JTB
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![BU of 7jtb by Molmil](/molmil-images/mine/7jtb) | |
4RIM
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6SC7
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![BU of 6sc7 by Molmil](/molmil-images/mine/6sc7) | dAb3/HOIP-RBR-Ligand3 | Descriptor: | CHLORIDE ION, E3 ubiquitin-protein ligase RNF31, SULFATE ION, ... | Authors: | Tsai, Y.-C.I, Johansson, H, House, D, Rittinger, K. | Deposit date: | 2019-07-23 | Release date: | 2019-11-27 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | Single-Domain Antibodies as Crystallization Chaperones to Enable Structure-Based Inhibitor Development for RBR E3 Ubiquitin Ligases. Cell Chem Biol, 27, 2020
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8K0B
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![BU of 8k0b by Molmil](/molmil-images/mine/8k0b) | Cryo-EM structure of TMEM63C | Descriptor: | Calcium permeable stress-gated cation channel 1 | Authors: | Qin, Y, Yu, D, Dong, J, Dang, S. | Deposit date: | 2023-07-08 | Release date: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (3.56 Å) | Cite: | Cryo-EM structure of TMEM63C suggests it functions as a monomer. Nat Commun, 14, 2023
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6UVX
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![BU of 6uvx by Molmil](/molmil-images/mine/6uvx) | The crystal structure of FbiA from Mycobacterium Smegmatis, Apo state | Descriptor: | CALCIUM ION, Phosphoenolpyruvate transferase | Authors: | Grinter, R, Gillett, D, Cordero, P.R.F, Greening, C. | Deposit date: | 2019-11-04 | Release date: | 2020-05-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Cellular and Structural Basis of Synthesis of the Unique Intermediate Dehydro-F420-0 in Mycobacteria. mSystems, 5, 2020
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7KCU
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![BU of 7kcu by Molmil](/molmil-images/mine/7kcu) | Joint neutron/X-ray structure of Oxyferrous Dehaloperoxidase B | Descriptor: | Dehaloperoxidase B, OXYGEN MOLECULE, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Carey, L.M, Ghiladi, R.A, Meilleur, F, Myles, D. | Deposit date: | 2020-10-07 | Release date: | 2021-10-13 | Last modified: | 2023-10-25 | Method: | NEUTRON DIFFRACTION (2.2 Å), X-RAY DIFFRACTION | Cite: | Complementarity of neutron, XFEL and synchrotron crystallography for defining the structures of metalloenzymes at room temperature. Iucrj, 9, 2022
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7XDQ
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![BU of 7xdq by Molmil](/molmil-images/mine/7xdq) | Crystal structure of a glucosylglycerol phosphorylase mutant from Marinobacter adhaerens | Descriptor: | Glucosylglycerol phosphorylase, LITHIUM ION, beta-D-glucopyranose | Authors: | Wei, H.L, Li, Q, Yang, J.G, Liu, W.D, Sun, Y.X. | Deposit date: | 2022-03-28 | Release date: | 2023-02-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | Protein Engineering of Glucosylglycerol Phosphorylase Facilitating Efficient and Highly Regio- and Stereoselective Glycosylation of Polyols in a Synthetic System. Acs Catalysis, 2022
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7K4M
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![BU of 7k4m by Molmil](/molmil-images/mine/7k4m) | Crystal structure of MetAP2 Modified Hemoglobin S | Descriptor: | CARBON MONOXIDE, Hemoglobin subunit alpha, Hemoglobin subunit beta, ... | Authors: | Musayev, F.N, Safo, M.K, Light, D.R. | Deposit date: | 2020-09-15 | Release date: | 2021-10-13 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | MetAP2 inhibition modifies hemoglobin S to delay polymerization and improves blood flow in sickle cell disease. Blood Adv, 5, 2021
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6EV7
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![BU of 6ev7 by Molmil](/molmil-images/mine/6ev7) | Structure of E282D A. niger Fdc1 with prFMN in the iminium form | Descriptor: | 1-deoxy-5-O-phosphono-1-(3,3,4,5-tetramethyl-9,11-dioxo-2,3,8,9,10,11-hexahydro-7H-quinolino[1,8-fg]pteridin-12-ium-7-y l)-D-ribitol, Ferulic acid decarboxylase 1, MANGANESE (II) ION, ... | Authors: | Bailey, S.S, Leys, D, Payne, K.A.P. | Deposit date: | 2017-11-01 | Release date: | 2017-12-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.06 Å) | Cite: | The role of conserved residues in Fdc decarboxylase in prenylated flavin mononucleotide oxidative maturation, cofactor isomerization, and catalysis. J. Biol. Chem., 293, 2018
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6LJA
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![BU of 6lja by Molmil](/molmil-images/mine/6lja) | Crystal Structure of exoHep from Bacteroides intestinalis DSM 17393 complexed with disaccharide product | Descriptor: | 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, CALCIUM ION, Heparinase II/III-like protein | Authors: | Zhang, Q.D, Cao, H.Y, Wei, L, Li, F.C, Zhang, Y.Z. | Deposit date: | 2019-12-13 | Release date: | 2020-12-23 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.978 Å) | Cite: | Discovery of exolytic heparinases and their catalytic mechanism and potential application. Nat Commun, 12, 2021
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6RCC
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![BU of 6rcc by Molmil](/molmil-images/mine/6rcc) | Domain C P140 Mycoplasma genitalium | Descriptor: | Adhesin P1, CHLORIDE ION, SODIUM ION | Authors: | Vizarraga, D, Aparicio, D, Perez, R, Illanes, R, Fita, I. | Deposit date: | 2019-04-11 | Release date: | 2020-11-04 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.43 Å) | Cite: | Alternative conformation of the C-domain of the P140 protein from Mycoplasma genitalium. Acta Crystallogr.,Sect.F, 76, 2020
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5KMQ
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6V6O
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![BU of 6v6o by Molmil](/molmil-images/mine/6v6o) | EGFR(T790M/V948R) in complex with LN2380 | Descriptor: | CHLORIDE ION, Epidermal growth factor receptor, N-[3-({4-[4-(4-fluorophenyl)-2-(3-hydroxypropyl)-1H-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Authors: | Heppner, D.E, Eck, M.J. | Deposit date: | 2019-12-05 | Release date: | 2020-04-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Basis for EGFR Mutant Inhibition by Trisubstituted Imidazole Inhibitors. J.Med.Chem., 63, 2020
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7R21
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![BU of 7r21 by Molmil](/molmil-images/mine/7r21) | elongated Cascade complex from type I-A CRISPR-Cas system | Descriptor: | Cas11a, Cas7a, CrRNA (62-MER), ... | Authors: | Hu, C, Ni, D, Nam, K.H, Stahlberg, H, Terns, M, Ke, A. | Deposit date: | 2022-02-04 | Release date: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural snapshots for an atypic type I CRISPR-Cas system To Be Published
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8JQJ
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![BU of 8jqj by Molmil](/molmil-images/mine/8jqj) | Crystal structure of carbonyl reductase SSCR mutant 1 from Sporobolomyces Salmonicolor | Descriptor: | Aldehyde reductase 2 | Authors: | Zhang, H.L, Li, Q, Liu, W.D, Chen, X, Wu, Q.Q, Zhu, D.M. | Deposit date: | 2023-06-14 | Release date: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Engineering a Carbonyl Reductase to Simultaneously Increase Activity Toward Bulky Ketone and Isopropanol for Dynamic Kinetic Asymmetric Reduction via Enzymatic Hydrogen Transfer Acs Catalysis, 13, 2023
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5CWF
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![BU of 5cwf by Molmil](/molmil-images/mine/5cwf) | |
8DOM
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7KEH
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![BU of 7keh by Molmil](/molmil-images/mine/7keh) | Crystal structure from SARS-CoV-2 NendoU NSP15 | Descriptor: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SULFATE ION, Uridylate-specific endoribonuclease | Authors: | Godoy, A.S, Nakamura, A.M, Pereira, H.M, Noske, G.D, Gawriljuk, V.O, Fernandes, R.S, Oliveira, K.I.Z, Oliva, G. | Deposit date: | 2020-10-10 | Release date: | 2020-12-02 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease. Nucleic Acids Res., 2023
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6VER
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![BU of 6ver by Molmil](/molmil-images/mine/6ver) | Human insulin analog: [GluB10,TyrB20]-DOI | Descriptor: | Insulin A chain, Insulin B chain | Authors: | Menting, J.G, Chou, D.H.-C, Lawrence, M.C, Xiong, X. | Deposit date: | 2020-01-02 | Release date: | 2020-11-11 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.047 Å) | Cite: | Mini-Ins: A minimal, bioactive insulin analog with alternative binding modes not published
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4RR2
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![BU of 4rr2 by Molmil](/molmil-images/mine/4rr2) | Crystal structure of human primase | Descriptor: | DNA primase large subunit, DNA primase small subunit, IRON/SULFUR CLUSTER, ... | Authors: | Baranovskiy, A.G, Gu, J, Suwa, Y, Babayeva, N.D, Tahirov, T.H. | Deposit date: | 2014-11-05 | Release date: | 2015-01-21 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Crystal structure of the human primase. J.Biol.Chem., 290, 2015
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7XHP
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6UW3
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![BU of 6uw3 by Molmil](/molmil-images/mine/6uw3) | The crystal structure of FbiA from Mycobacterium Smegmatis, GDP Bound form | Descriptor: | CALCIUM ION, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Grinter, R, Gillett, D, Cordero, P.R.F, Greening, C. | Deposit date: | 2019-11-04 | Release date: | 2020-05-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Cellular and Structural Basis of Synthesis of the Unique Intermediate Dehydro-F420-0 in Mycobacteria. mSystems, 5, 2020
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