6SC7

dAb3/HOIP-RBR-Ligand3

Summary for 6SC7

Entry DOI	10.2210/pdb6sc7/pdb
Descriptor	E3 ubiquitin-protein ligase RNF31, Single domain antibody, [2-[3-(cyclooct-4-en-1-yloxycarbonylamino)propylamino]-2-oxidanylidene-ethyl] (~{E})-4-[(2-oxidanylidene-5,6,7,8-tetrahydro-1~{H}-quinolin-3-yl)carbonylamino]but-2-enoate, ... (7 entities in total)
Functional Keywords	human single domain antibody, hoip, rbr, inhibitor, ligase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	70879.13
Authors	Tsai, Y.-C.I.,Johansson, H.,House, D.,Rittinger, K. (deposition date: 2019-07-23, release date: 2019-11-27, Last modification date: 2024-05-01)
Primary citation	Tsai, Y.I.,Johansson, H.,Dixon, D.,Martin, S.,Chung, C.W.,Clarkson, J.,House, D.,Rittinger, K. Single-Domain Antibodies as Crystallization Chaperones to Enable Structure-Based Inhibitor Development for RBR E3 Ubiquitin Ligases. Cell Chem Biol, 27:83-, 2020 Cited by PubMed: 31813847 DOI: 10.1016/j.chembiol.2019.11.007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.56 Å)

Structure validation