7S1G
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![BU of 7s1g by Molmil](/molmil-images/mine/7s1g) | wild-type Escherichia coli stalled ribosome with antibiotic linezolid | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Young, I.D, Stojkovic, V, Tsai, K, Lee, D.J, Fraser, J.S, Galonic Fujimori, D. | 登録日 | 2021-09-02 | 公開日 | 2021-11-17 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.48 Å) | 主引用文献 | Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics. Nat.Struct.Mol.Biol., 29, 2022
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7S1H
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![BU of 7s1h by Molmil](/molmil-images/mine/7s1h) | Wild-type Escherichia coli ribosome with antibiotic linezolid | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Young, I.D, Stojkovic, V, Tsai, K, Lee, D.J, Fraser, J.S, Galonic Fujimori, D. | 登録日 | 2021-09-02 | 公開日 | 2021-11-17 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.35 Å) | 主引用文献 | Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics. Nat.Struct.Mol.Biol., 29, 2022
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8G4S
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![BU of 8g4s by Molmil](/molmil-images/mine/8g4s) | 40S ribosomal subunit of the 80S Giardia intestinalis assemblage A ribosome with Emetine bound in V2 conformation with mRNA and three tRNAs. | 分子名称: | 18S rRNA, 40S ribosomal protein S21, 40S ribosomal protein S25, ... | 著者 | Eiler, D.R, Wimberly, B.T, Bilodeau, D.Y, Rissland, O.S, Kieft, J.S. | 登録日 | 2023-02-10 | 公開日 | 2024-01-31 | 最終更新日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | 主引用文献 | The Giardia lamblia ribosome structure reveals divergence in several biological pathways and the mode of emetine function. Structure, 32, 2024
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8GMH
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![BU of 8gmh by Molmil](/molmil-images/mine/8gmh) | Crystal Structure of the ternary complex of TelA-LXG, LapA3, and LapA4 | 分子名称: | 1,2-ETHANEDIOL, LXG domain-containing protein, LapA3, ... | 著者 | Klein, T.A, Shah, P.Y, Gkragkopoulou, P, Grebenc, D.W, Kim, Y, Whitney, J.C. | 登録日 | 2023-03-25 | 公開日 | 2024-01-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure of a tripartite protein complex that targets toxins to the type VII secretion system. Proc.Natl.Acad.Sci.USA, 121, 2024
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3KG7
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6X4Q
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![BU of 6x4q by Molmil](/molmil-images/mine/6x4q) | Human cyclophilin A bound to a series of acylcic and macrocyclic inhibitors: (2R,5S,11S,14S,18E)-14-cyclobutyl-2,11,17,17-tetramethyl-15-oxa-3,9,12,26,29-pentaazatetracyclo[18.5.3.1~5,9~.0~23,27~]nonacosa-1(25),18,20(28),21,23,26-hexaene-4,10,13,16-tetrone (compound 33) | 分子名称: | (2R,5S,11S,14S,18E)-14-cyclobutyl-2,11,17,17-tetramethyl-15-oxa-3,9,12,26,29-pentaazatetracyclo[18.5.3.1~5,9~.0~23,27~]nonacosa-1(25),18,20(28),21,23,26-hexaene-4,10,13,16-tetrone, Peptidyl-prolyl cis-trans isomerase A | 著者 | Appleby, T.C, Paulsen, J.L, Schmitz, U, Shivakumar, D. | 登録日 | 2020-05-22 | 公開日 | 2020-06-24 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Evaluation of Free Energy Calculations for the Prioritization of Macrocycle Synthesis. J.Chem.Inf.Model., 60, 2020
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6QU5
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![BU of 6qu5 by Molmil](/molmil-images/mine/6qu5) | Crystal Structure of Phosphofructokinase from Trypanosoma brucei in complex with an allosteric inhibitor ctcb12 | 分子名称: | 1-[(3,4-dichlorophenyl)methyl]imidazole, ATP-dependent 6-phosphofructokinase, CITRIC ACID, ... | 著者 | McNae, I.W, Dornan, J, Walkinshaw, M.D. | 登録日 | 2019-02-26 | 公開日 | 2020-03-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice. Nat Commun, 12, 2021
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8G1R
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![BU of 8g1r by Molmil](/molmil-images/mine/8g1r) | A Vibrio cholerae viral satellite enables efficient horizontal transfer by using an external scaffold to assemble hijacked coat proteins into small capsids | 分子名称: | Serine protease, major head protein | 著者 | Subramanian, S, Boyd, C.M, Seed, K.D, Parent, K.N. | 登録日 | 2023-02-02 | 公開日 | 2024-01-17 | 最終更新日 | 2024-01-24 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | A Vibrio cholerae viral satellite maximizes its spread and inhibits phage by remodeling hijacked phage coat proteins into small capsids. Elife, 12, 2024
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2FZF
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![BU of 2fzf by Molmil](/molmil-images/mine/2fzf) | Hypothetical Protein Pfu-1136390-001 From Pyrococcus furiosus | 分子名称: | hypothetical protein | 著者 | Fu, Z.-Q, Liu, Z.-J, Lee, D, Kelley, L, Chen, L, Tempel, W, Shah, N, Horanyi, P, Lee, H.S, Habel, J, Dillard, B.D, Nguyen, D, Chang, S.-H, Zhang, H, Chang, J, Sugar, F.J, Poole, F.L, Jenney Jr, F.E, Adams, M.W.W, Rose, J.P, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG) | 登録日 | 2006-02-09 | 公開日 | 2006-02-21 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Hypothetical Protein Pfu-1136390-001 From Pyrococcus furiosus To be published
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5KMZ
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4O32
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![BU of 4o32 by Molmil](/molmil-images/mine/4o32) | Structure of a malarial protein | 分子名称: | CHLORIDE ION, Thioredoxin | 著者 | Egea, P.F, Koehl, A, Peng, M, Cascio, D. | 登録日 | 2013-12-17 | 公開日 | 2014-12-24 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.196 Å) | 主引用文献 | Crystal structure and solution characterization of the thioredoxin-2 from Plasmodium falciparum, a constituent of an essential parasitic protein export complex. Biochem.Biophys.Res.Commun., 456, 2015
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1HXH
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![BU of 1hxh by Molmil](/molmil-images/mine/1hxh) | COMAMONAS TESTOSTERONI 3BETA/17BETA HYDROXYSTEROID DEHYDROGENASE | 分子名称: | 3BETA/17BETA-HYDROXYSTEROID DEHYDROGENASE | 著者 | Benach, J, Filling, C, Oppermann, U.C.T, Roversi, P, Bricogne, G, Berndt, K.D, Jornvall, H, Ladenstein, R. | 登録日 | 2001-01-15 | 公開日 | 2002-12-25 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.22 Å) | 主引用文献 | Structure of Bacterial 3beta/17beta-Hydroxysteroid Dehydrogenase at 1.2 A Resolution: A Model for
Multiple Steroid Recognition Biochemistry, 41, 2002
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5KRF
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![BU of 5krf by Molmil](/molmil-images/mine/5krf) | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the Dynamic WAY derivative, 1a | 分子名称: | 4-[1-methyl-7-(trifluoromethyl)indazol-3-yl]benzene-1,3-diol, Estrogen receptor, KHKILHRLLQDSSS Peptide | 著者 | Nwachukwu, J.C, Srinivasan, S, Bruno, N.E, Nowak, J, Kojetin, D.J, Elemento, O, Katzenellenbogen, J.A, Nettles, K.W. | 登録日 | 2016-07-07 | 公開日 | 2017-02-15 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.193 Å) | 主引用文献 | Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24, 2017
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7R74
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6QPS
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![BU of 6qps by Molmil](/molmil-images/mine/6qps) | Structural characterization of a mannuronic acid specific polysaccharide family 6 lyase enzyme from human gut microbiota | 分子名称: | ACETATE ION, CALCIUM ION, Polysaccharide Lyase Family 6 | 著者 | Fredslund, F, Stender, E.G.P, Svensson, B, Welner, D.H. | 登録日 | 2019-02-14 | 公開日 | 2019-09-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.287 Å) | 主引用文献 | Structural and functional aspects of mannuronic acid-specific PL6 alginate lyase from the human gut microbeBacteroides cellulosilyticus. J.Biol.Chem., 294, 2019
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6WWA
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![BU of 6wwa by Molmil](/molmil-images/mine/6wwa) | Crystal structure of human SHLD2-SHLD3-REV7 complex | 分子名称: | Mitotic spindle assembly checkpoint protein MAD2B, Shieldin complex subunit 2,Shieldin complex subunit 3 chimera | 著者 | Xie, W, Patel, D.J. | 登録日 | 2020-05-08 | 公開日 | 2021-03-03 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Molecular mechanisms of assembly and TRIP13-mediated remodeling of the human Shieldin complex. Proc.Natl.Acad.Sci.USA, 118, 2021
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2FWY
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1HTO
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4NYU
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![BU of 4nyu by Molmil](/molmil-images/mine/4nyu) | Structure of Vibrio cholerae chitin de-N-acetylase in complex with acetate ion (ACT) in C 2 2 21 | 分子名称: | ACETATE ION, CALCIUM ION, Deacetylase DA1, ... | 著者 | Albesa-Jove, D, Andres, E, Biarnes, X, Planas, A, Guerin, M.E. | 登録日 | 2013-12-11 | 公開日 | 2014-08-13 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Structural basis of chitin oligosaccharide deacetylation. Angew.Chem.Int.Ed.Engl., 53, 2014
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5DR9
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![BU of 5dr9 by Molmil](/molmil-images/mine/5dr9) | Aurora A Kinase in Complex with AA29 and JNJ-7706621 in Space Group P6122 | 分子名称: | 2-(3-bromophenyl)-6-chloroquinoline-4-carboxylic acid, 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzenesulfonamide, Aurora kinase A | 著者 | Janecek, M, Rossmann, M, Sharma, P, Emery, A, McKenzie, G.J, Huggins, D.J, Stockwell, S, Stokes, J.A, Almeida, E.G, Hardwick, B, Narvaez, A.J, Hyvonen, M, Spring, D.R, Venkitaraman, A.R. | 登録日 | 2015-09-15 | 公開日 | 2016-07-20 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2. Sci Rep, 6, 2016
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5DPV
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![BU of 5dpv by Molmil](/molmil-images/mine/5dpv) | Aurora A Kinase in Complex with AA35 and JNJ-7706621 in Space Group P6122 | 分子名称: | 2-(3-bromophenyl)-8-fluoroquinoline-4-carboxylic acid, 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzenesulfonamide, Aurora kinase A | 著者 | Janecek, M, Rossmann, M, Sharma, P, Emery, A, McKenzie, G.J, Huggins, D.J, Stockwell, S, Stokes, J.A, Almeida, E.G, Hardwick, B, Narvaez, A.J, Hyvonen, M, Spring, D.R, Venkitaraman, A.R. | 登録日 | 2015-09-14 | 公開日 | 2016-07-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.285 Å) | 主引用文献 | Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2. Sci Rep, 6, 2016
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3KYC
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![BU of 3kyc by Molmil](/molmil-images/mine/3kyc) | Human SUMO E1 complex with a SUMO1-AMP mimic | 分子名称: | 5'-deoxy-5'-(sulfamoylamino)adenosine, SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, ... | 著者 | Lima, C.D. | 登録日 | 2009-12-05 | 公開日 | 2010-02-16 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Active site remodelling accompanies thioester bond formation in the SUMO E1. Nature, 463, 2010
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4F4S
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5L3A
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![BU of 5l3a by Molmil](/molmil-images/mine/5l3a) | Fragment-based discovery of 6-arylindazole JAK inhibitors | 分子名称: | Tyrosine-protein kinase JAK2, ~{N}-(1~{H}-indazol-4-yl)methanesulfonamide | 著者 | Soerensen, M.D, Dack, K.N, Greve, D.R, Ritzen, A. | 登録日 | 2016-04-06 | 公開日 | 2016-04-27 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Fragment-Based Discovery of 6-Arylindazole JAK Inhibitors. Acs Med.Chem.Lett., 7, 2016
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3L4P
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![BU of 3l4p by Molmil](/molmil-images/mine/3l4p) | |