5KRF

Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the Dynamic WAY derivative, 1a

Summary for 5KRF

Entry DOI	10.2210/pdb5krf/pdb
Descriptor	Estrogen receptor, KHKILHRLLQDSSS Peptide, 4-[1-methyl-7-(trifluoromethyl)indazol-3-yl]benzene-1,3-diol, ... (4 entities in total)
Functional Keywords	nuclear receptor, transcription factor, ligand binding, protein-ligand complex, transcription
Biological source	Homo sapiens (Human) More
Cellular location	Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372
Total number of polymer chains	4
Total formula weight	62549.47
Authors	Nwachukwu, J.C.,Srinivasan, S.,Bruno, N.E.,Nowak, J.,Kojetin, D.J.,Elemento, O.,Katzenellenbogen, J.A.,Nettles, K.W. (deposition date: 2016-07-07, release date: 2017-02-15, Last modification date: 2024-03-06)
Primary citation	Nwachukwu, J.C.,Srinivasan, S.,Bruno, N.E.,Nowak, J.,Wright, N.J.,Minutolo, F.,Rangarajan, E.S.,Izard, T.,Yao, X.Q.,Grant, B.J.,Kojetin, D.J.,Elemento, O.,Katzenellenbogen, J.A.,Nettles, K.W. Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24:35-45, 2017 Cited by PubMed: 28042045 DOI: 10.1016/j.chembiol.2016.11.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.193 Å)

Structure validation