7T19
| Rev1 Ternary Complex with dGTP and Ca2+ | 分子名称: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*CP*AP*TP*CP*GP*CP*TP*AP*CP*CP*AP*CP*AP*CP*CP*CP*C)-3'), ... | 著者 | Freudenthal, B.D, Weaver, T.M. | 登録日 | 2021-12-01 | 公開日 | 2022-05-25 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1. Nat Commun, 13, 2022
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7T1B
| Rev1 Ternary Complex with rCTP and Ca2+ | 分子名称: | CALCIUM ION, CYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*TP*CP*GP*CP*TP*AP*CP*CP*AP*CP*AP*CP*CP*CP*C)-3'), ... | 著者 | Freudenthal, B.D, Weaver, T.M. | 登録日 | 2021-12-01 | 公開日 | 2022-05-25 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1. Nat Commun, 13, 2022
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7T9G
| Structure of VcINDY-Na+ | 分子名称: | DASS family sodium-coupled anion symporter, SODIUM ION | 著者 | Sauer, D.B, Marden, J.J, Song, J.M, Wang, D.N. | 登録日 | 2021-12-19 | 公開日 | 2022-05-25 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | 主引用文献 | Structural basis of ion - substrate coupling in the Na + -dependent dicarboxylate transporter VcINDY. Nat Commun, 13, 2022
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7NTE
| The structure of an open conformation of the SBP TarP_Csal | 分子名称: | MAGNESIUM ION, TRAP dicarboxylate transporter-DctP subunit | 著者 | Bisson, C, Salmon, R.C, West, L, Rafferty, J.B, Hitchcock, A, Thomas, G.H, Kelly, D.J. | 登録日 | 2021-03-09 | 公開日 | 2021-10-06 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | The structural basis for high-affinity uptake of lignin-derived aromatic compounds by proteobacterial TRAP transporters. Febs J., 289, 2022
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8PKW
| Kelch domain of KEAP1 in complex with a ortho-dimethylbenzene linked cyclic peptide 5 (ortho-WRCDPETaEC). | 分子名称: | (2-methylphenyl)methanol, 1,2-ETHANEDIOL, CHLORIDE ION, ... | 著者 | Braun, M.B, Bischof, L, Hartmann, M.D. | 登録日 | 2023-06-27 | 公開日 | 2023-11-15 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Computational Prediction of Cyclic Peptide Structural Ensembles and Application to the Design of Keap1 Binders. J.Chem.Inf.Model., 63, 2023
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7T18
| Rev1 Ternary Complex with dTTP and Ca2+ | 分子名称: | CALCIUM ION, DNA (5'-D(*AP*TP*CP*GP*CP*TP*AP*CP*CP*AP*CP*AP*CP*CP*CP*C)-3'), DNA (5'-D(P*GP*GP*GP*GP*TP*GP*TP*GP*GP*TP*AP*G)-3'), ... | 著者 | Freudenthal, B.D, Weaver, T.M. | 登録日 | 2021-12-01 | 公開日 | 2022-05-25 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1. Nat Commun, 13, 2022
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6PCQ
| E. coli 50S ribosome bound to VM2 | 分子名称: | (3R,4R,5E,10E,12E,14S,26aR)-14-hydroxy-4,12-dimethyl-3-(propan-2-yl)-8,9,14,15,24,25,26,26a-octahydro-1H,3H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,16,22(4H,17H)-tetrone, 23S ribosomal RNA, 50S ribosomal protein L13, ... | 著者 | Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B. | 登録日 | 2019-06-18 | 公開日 | 2020-06-17 | 最終更新日 | 2020-10-07 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Synthetic group A streptogramin antibiotics that overcome Vat resistance. Nature, 586, 2020
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7T1A
| Rev1 Ternary Complex with dATP and Ca2+ | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*TP*CP*GP*CP*TP*AP*CP*CP*AP*CP*AP*CP*CP*CP*C)-3'), ... | 著者 | Freudenthal, B.D, Weaver, T.M. | 登録日 | 2021-12-01 | 公開日 | 2022-05-25 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1. Nat Commun, 13, 2022
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8PKX
| Kelch domain of KEAP1 in complex with a ortho-dimethylbenzene linked cyclic peptide 11 (ortho-WRCNPETaEC). | 分子名称: | (2-methylphenyl)methanol, 1,2-ETHANEDIOL, CHLORIDE ION, ... | 著者 | Braun, M.B, Bischof, L, Hartmann, M.D. | 登録日 | 2023-06-27 | 公開日 | 2023-11-15 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Computational Prediction of Cyclic Peptide Structural Ensembles and Application to the Design of Keap1 Binders. J.Chem.Inf.Model., 63, 2023
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6PCT
| E. coli 50S ribosome bound to compound 41q | 分子名称: | (2S)-2-[(3S,4R,5E,10E,12E,14S,26aR)-14-hydroxy-4,12-dimethyl-1,7,16,22-tetraoxo-4,7,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,3H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosin-3-yl]propyl isoquinolin-3-ylcarbamate, 23S ribosomal RNA, 50S ribosomal protein L13, ... | 著者 | Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B. | 登録日 | 2019-06-18 | 公開日 | 2020-06-17 | 最終更新日 | 2020-10-07 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Synthetic group A streptogramin antibiotics that overcome Vat resistance. Nature, 586, 2020
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6PI8
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7O2R
| Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with ITF3985 | 分子名称: | 3,5-bis(fluoranyl)-~{N}-oxidanyl-4-[(5-pyrimidin-2-yl-1,2,3,4-tetrazol-2-yl)methyl]benzamide, DI(HYDROXYETHYL)ETHER, Histone deacetylase 6, ... | 著者 | Zrubek, K, Sandrone, G, Cukier, C.D, Stevenazzi, A. | 登録日 | 2021-03-31 | 公開日 | 2021-10-27 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Role of Fluorination in the Histone Deacetylase 6 (HDAC6) Selectivity of Benzohydroxamate-Based Inhibitors. Acs Med.Chem.Lett., 12, 2021
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7O2P
| Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with ITF3756 | 分子名称: | 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, ... | 著者 | Zrubek, K, Sandrone, G, Cukier, C.D, Stevenazzi, A. | 登録日 | 2021-03-31 | 公開日 | 2021-10-27 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Role of Fluorination in the Histone Deacetylase 6 (HDAC6) Selectivity of Benzohydroxamate-Based Inhibitors. Acs Med.Chem.Lett., 12, 2021
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6YEW
| Morganella morganii TcdA4 in complex with porcine mucosa heparin | 分子名称: | Insecticidal toxin protein | 著者 | Roderer, D, Broecker, F, Sitsel, O, Kaplonek, P, Leidreiter, F, Seeberger, P.H, Raunser, S. | 登録日 | 2020-03-25 | 公開日 | 2020-07-08 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Glycan-dependent cell adhesion mechanism of Tc toxins. Nat Commun, 11, 2020
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7OFZ
| Nontypeable Haemophillus influenzae SapA in complex with double stranded RNA | 分子名称: | ABC-type transport system, periplasmic component, involved in antimicrobial peptide resistance, ... | 著者 | Lukacik, P, Owen, C.D, Nettleship, J.E, Bird, L.E, Owens, R.J, Walsh, M.A. | 登録日 | 2021-05-05 | 公開日 | 2021-10-27 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | The structure of nontypeable Haemophilus influenzae SapA in a closed conformation reveals a constricted ligand-binding cavity and a novel RNA binding motif. Plos One, 16, 2021
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7AV6
| FAST in a domain-swapped dimer form | 分子名称: | FORMIC ACID, Photoactive yellow protein | 著者 | Bukhdruker, S, Remeeva, A, Ruchkin, D, Gorbachev, D, Povarova, N, Mineev, K, Goncharuk, S, Baranov, M, Mishin, A, Borshchevskiy, V. | 登録日 | 2020-11-04 | 公開日 | 2021-06-09 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | NanoFAST: structure-based design of a small fluorogen-activating protein with only 98 amino acids. Chem Sci, 12, 2021
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6MKF
| Crystal structure of penicillin binding protein 5 (PBP5) from Enterococcus faecium in the imipenem-bound form | 分子名称: | (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox ylic acid, SULFATE ION, penicillin binding protein 5 (PBP5) | 著者 | Moon, T.M, Lee, C, D'Andrea, E.D, Peti, W, Page, R. | 登録日 | 2018-09-25 | 公開日 | 2018-10-31 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | The structures of penicillin-binding protein 4 (PBP4) and PBP5 fromEnterococciprovide structural insights into beta-lactam resistance. J. Biol. Chem., 293, 2018
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7OFW
| Nontypeable Haemophillus influenzae SapA in complex with heme | 分子名称: | ABC-type transport system, periplasmic component, involved in antimicrobial peptide resistance, ... | 著者 | Lukacik, P, Owen, C.D, Nettleship, J.E, Bird, L.E, Owens, R.J, Walsh, M.A. | 登録日 | 2021-05-05 | 公開日 | 2021-10-27 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | The structure of nontypeable Haemophilus influenzae SapA in a closed conformation reveals a constricted ligand-binding cavity and a novel RNA binding motif. Plos One, 16, 2021
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6MH2
| Structure of Herceptin Fab without antigen | 分子名称: | Herceptin Fab arm heavy chain, Herceptin Fab arm light chain | 著者 | Luthra, A, Langley, D.B, Christie, M, Christ, D. | 登録日 | 2018-09-17 | 公開日 | 2019-05-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Human Antibody Bispecifics through Phage Display Selection. Biochemistry, 58, 2019
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6PC6
| E. coli 50S ribosome bound to compound 47 | 分子名称: | (3R,4R,5E,10E,12E,14S,16R,26aR)-16-fluoro-14-hydroxy-12-methyl-3-(propan-2-yl)-4-(prop-2-en-1-yl)-3,4,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,7H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,22-trione, 23S ribosomal RNA, 50S ribosomal protein L13, ... | 著者 | Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B. | 登録日 | 2019-06-16 | 公開日 | 2020-06-17 | 最終更新日 | 2020-10-07 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Synthetic group A streptogramin antibiotics that overcome Vat resistance. Nature, 586, 2020
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6YL4
| Soluble epoxide hydrolase in complex with 3-((R)-3-(1-hydroxyureido)but-1-yn-1-yl)-N-((S)-3-phenyl-3-(4-trifluoromethoxy)phenyl)propyl)benzamide | 分子名称: | 3-[(3~{R})-3-[aminocarbonyl(oxidanyl)amino]but-1-ynyl]-~{N}-[(3~{S})-3-phenyl-3-[4-(trifluoromethyloxy)phenyl]propyl]benzamide, Bifunctional epoxide hydrolase 2 | 著者 | Kramer, J.S, Pogoryelov, D, Hiesinger, K, Proschak, E. | 登録日 | 2020-04-06 | 公開日 | 2020-10-21 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.001 Å) | 主引用文献 | Design, Synthesis, and Structure-Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase. J.Med.Chem., 63, 2020
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8TO3
| EGFR(T790M/V948R) in complex with LN5461 | 分子名称: | 3-hydroxy-N-{(3P)-3-[(4P)-2-(methylsulfanyl)-5-{2-[4-(piperazin-1-yl)anilino]pyridin-4-yl}-1H-imidazol-4-yl]phenyl}-2-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]benzamide, Epidermal growth factor receptor, MAGNESIUM ION, ... | 著者 | Chitnis, S.C, Pham, C.D, Heppner, D.E. | 登録日 | 2023-08-02 | 公開日 | 2024-08-28 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | EGFR(T790M/V948R) in complex with LN5461 To Be Published
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8FLR
| Human PTH1R in complex with PTHrP and Gs | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M. | 登録日 | 2022-12-22 | 公開日 | 2023-04-26 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | 主引用文献 | Molecular insights into peptide agonist engagement with the PTH receptor. Structure, 31, 2023
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6YS5
| Acinetobacter baumannii ribosome-amikacin complex - 30S subunit head | 分子名称: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S13, ... | 著者 | Nicholson, D, Edwards, T.A, O'Neill, A.J, Ranson, N.A. | 登録日 | 2020-04-21 | 公開日 | 2020-09-16 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure of the 70S Ribosome from the Human Pathogen Acinetobacter baumannii in Complex with Clinically Relevant Antibiotics. Structure, 28, 2020
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8J3R
| Cryo-EM structure of the AsCas12f-HKRA-sgRNAS3-5v7-target DNA | 分子名称: | DNA (37-MER), DNA (38-MER), MAGNESIUM ION, ... | 著者 | Hino, T, Omura, N.S, Nakagawa, R, Togashi, T, Takeda, N.S, Hiramoto, T, Tasaka, S, Hirano, H, Tokuyama, T, Uosaki, H, Ishiguro, H, Yamano, H, Ozaki, Y, Motooka, D, Mori, H, Kirita, Y, Kise, Y, Itoh, Y, Matoba, S, Aburatani, H, Yachie, N, Siksnys, V, Ohmori, T, Hoshino, A, Nureki, O. | 登録日 | 2023-04-18 | 公開日 | 2023-09-27 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | Minimal and most efficient genome editing Cas enzyme To Be Published
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