7O2P
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with ITF3756
Summary for 7O2P
Entry DOI | 10.2210/pdb7o2p/pdb |
Descriptor | Histone deacetylase 6, ~{N}-oxidanyl-4-[(5-thiophen-2-yl-1,2,3,4-tetrazol-1-yl)methyl]benzamide, ZINC ION, ... (10 entities in total) |
Functional Keywords | histone deacetylase, complex with hydroxamate inhibitor, hydrolase |
Biological source | Danio rerio (Zebrafish, Brachydanio rerio) |
Total number of polymer chains | 2 |
Total formula weight | 83436.03 |
Authors | Zrubek, K.,Sandrone, G.,Cukier, C.D.,Stevenazzi, A. (deposition date: 2021-03-31, release date: 2021-10-27, Last modification date: 2024-01-31) |
Primary citation | Sandrone, G.,Cukier, C.D.,Zrubek, K.,Marchini, M.,Vergani, B.,Caprini, G.,Fossati, G.,Steinkuhler, C.,Stevenazzi, A. Role of Fluorination in the Histone Deacetylase 6 (HDAC6) Selectivity of Benzohydroxamate-Based Inhibitors. Acs Med.Chem.Lett., 12:1810-1817, 2021 Cited by PubMed: 34795871DOI: 10.1021/acsmedchemlett.1c00425 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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