8DUW
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![BU of 8duw by Molmil](/molmil-images/mine/8duw) | HnRNPA2 D290V LCD PM2 | 分子名称: | Heterogeneous nuclear ribonucleoproteins A2/B1 | 著者 | Eisenberg, D.S, Lu, J, Ge, P, Boyer, D.R. | 登録日 | 2022-07-27 | 公開日 | 2023-08-02 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation. J.Biol.Chem., 300, 2023
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6XF5
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![BU of 6xf5 by Molmil](/molmil-images/mine/6xf5) | Cryo-EM structure of a biotinylated SARS-CoV-2 spike probe in the prefusion state (RBDs down) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Cerutti, G, Gorman, J, Kwong, P.D, Shapiro, L. | 登録日 | 2020-06-15 | 公開日 | 2020-09-02 | 最終更新日 | 2020-12-02 | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | 主引用文献 | Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes. SSRN, 2020
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6M8M
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![BU of 6m8m by Molmil](/molmil-images/mine/6m8m) | PA14 sugar-binding domain from RTX adhesin | 分子名称: | CALCIUM ION, Putative large adhesion protein (Lap) involved in biofilm formation, SODIUM ION, ... | 著者 | Vance, T.D.R, Conroy, B, Davies, P.L. | 登録日 | 2018-08-22 | 公開日 | 2019-09-04 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Structure and functional analysis of a bacterial adhesin sugar-binding domain. Plos One, 14, 2019
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8EC7
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![BU of 8ec7 by Molmil](/molmil-images/mine/8ec7) | HnRNPA2 D290V LCD PM3 | 分子名称: | Heterogeneous nuclear ribonucleoproteins A2/B1 | 著者 | Eisenberg, D.S, Lu, J, Ge, P, Boyer, D.R. | 登録日 | 2022-09-01 | 公開日 | 2023-09-06 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation. J.Biol.Chem., 300, 2023
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8EDE
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![BU of 8ede by Molmil](/molmil-images/mine/8ede) | Crystal structure of covalent inhibitor 2-chloro-N'-(N-(4-chlorophenyl)-N-methylglycyl)acetohydrazide bound to Ubiquitin C-terminal Hydrolase-L1 | 分子名称: | 2-[(4-chlorophenyl)-methyl-amino]-~{N}'-ethanoyl-ethanehydrazide, SULFATE ION, Ubiquitin carboxyl-terminal hydrolase isozyme L1 | 著者 | Patel, R, Imhoff, R, Flaherty, D, Das, C. | 登録日 | 2022-09-04 | 公開日 | 2023-09-20 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (1.799 Å) | 主引用文献 | Covalent Fragment Screening and Optimization Identifies the Chloroacetohydrazide Scaffold as Inhibitors for Ubiquitin C-terminal Hydrolase L1. J.Med.Chem., 67, 2024
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7NN3
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![BU of 7nn3 by Molmil](/molmil-images/mine/7nn3) | A carbohydrate esterase family 15 (CE15) glucuronoyl esterase from Caldicellulosiruptor kristjansonii | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Beta-xylanase, ... | 著者 | Krska, D, Mazurkewich, S, Navarro Poulsen, J, Larsbrink, J, Lo Leggio, L. | 登録日 | 2021-02-24 | 公開日 | 2021-07-07 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.88948345 Å) | 主引用文献 | Structural and Functional Analysis of a Multimodular Hyperthermostable Xylanase-Glucuronoyl Esterase from Caldicellulosiruptor kristjansonii . Biochemistry, 60, 2021
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6M3Z
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![BU of 6m3z by Molmil](/molmil-images/mine/6m3z) | X-ray structure of a Drosophila dopamine transporter with NET-like mutations (D121G/S426M/F471L) in milnacipran bound form | 分子名称: | (1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenyl-cyclopropane-1-carboxamide, Antibody fragment 9D5 Light chain, Antibody fragment 9D5 heavy chain, ... | 著者 | Shabareesh, P, Mallela, A.K, Joseph, D, Penmatsa, A. | 登録日 | 2020-03-04 | 公開日 | 2021-02-17 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.11 Å) | 主引用文献 | Structural basis of norepinephrine recognition and transport inhibition in neurotransmitter transporters. Nat Commun, 12, 2021
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6M47
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![BU of 6m47 by Molmil](/molmil-images/mine/6m47) | X-ray structure of a Drosophila dopamine transporter with NET-like mutations (D121G/S426M/F471L) in tramadol bound form | 分子名称: | (1S,2S)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexan-1-ol, Antibody fragment 9D5 light chain, Antibody fragment Heavy chain, ... | 著者 | Shabareesh, P, Mallela, A.K, Joseph, D, Penmatsa, A. | 登録日 | 2020-03-05 | 公開日 | 2021-02-17 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.252 Å) | 主引用文献 | Structural basis of norepinephrine recognition and transport inhibition in neurotransmitter transporters. Nat Commun, 12, 2021
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6X79
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![BU of 6x79 by Molmil](/molmil-images/mine/6x79) | Prefusion SARS-CoV-2 S ectodomain trimer covalently stabilized in the closed conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | McCallum, M, Walls, A.C, Corti, D, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | 登録日 | 2020-05-29 | 公開日 | 2020-08-19 | 最終更新日 | 2021-01-27 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structure-guided covalent stabilization of coronavirus spike glycoprotein trimers in the closed conformation. Nat.Struct.Mol.Biol., 27, 2020
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8E2N
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7NFC
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![BU of 7nfc by Molmil](/molmil-images/mine/7nfc) | Cryo-EM structure of NHEJ super-complex (dimer) | 分子名称: | DNA (27-MER), DNA (28-MER), DNA ligase 4, ... | 著者 | Chaplin, A.K, Hardwick, S.W, Kefala Stavridi, A, Chirgadze, D.Y, Blundell, T.L. | 登録日 | 2021-02-05 | 公開日 | 2021-08-18 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (4.14 Å) | 主引用文献 | Cryo-EM of NHEJ supercomplexes provides insights into DNA repair. Mol.Cell, 81, 2021
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6OJA
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![BU of 6oja by Molmil](/molmil-images/mine/6oja) | Crystal structure of the N. meningitides methionine-binding protein in its L-methionine bound conformation | 分子名称: | Lipoprotein, METHIONINE | 著者 | Nguyen, P.T, Lai, J.Y, Kaiser, J.T, Rees, D.C. | 登録日 | 2019-04-11 | 公開日 | 2019-08-07 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Structures of the Neisseria meningitides methionine-binding protein MetQ in substrate-free form and bound to l- and d-methionine isomers. Protein Sci., 28, 2019
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6OKF
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![BU of 6okf by Molmil](/molmil-images/mine/6okf) | Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabB, and C16-crypto Acyl Carrier Protein, AcpP | 分子名称: | 3-oxoacyl-[acyl-carrier-protein] synthase 1, Acyl carrier protein, N-[2-(dodecanoylamino)ethyl]-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide, ... | 著者 | Mindrebo, J.T, Kim, W.E, Bartholow, T.G, Chen, A, Davis, T.D, La Clair, J, Burkart, M.D, Noel, J.P. | 登録日 | 2019-04-12 | 公開日 | 2020-04-22 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Gating mechanism of elongating beta-ketoacyl-ACP synthases. Nat Commun, 11, 2020
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7N83
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![BU of 7n83 by Molmil](/molmil-images/mine/7n83) | Crystal Structure of SARS-CoV-2 NendoU in complex with Z2443429438 | 分子名称: | (3S)-1-(phenylsulfonyl)pyrrolidin-3-amine, CITRIC ACID, Uridylate-specific endoribonuclease | 著者 | Godoy, A.S, Douangamath, A, Nakamura, A.M, Dias, A, Krojer, T, Noske, G.D, Gawiljuk, V.O, Fernandes, R.S, Fairhead, M, Powell, A, Dunnet, L, Aimon, A, Fearon, D, Brandao-Neto, J, Skyner, R, von Delft, F, Oliva, G. | 登録日 | 2021-06-12 | 公開日 | 2021-09-08 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease. Nucleic Acids Res., 51, 2023
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7N5X
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![BU of 7n5x by Molmil](/molmil-images/mine/7n5x) | Fragment-Based Discovery of a Novel Bruton's Tyrosine Kinase Inhibitor | 分子名称: | 5-(1-ethoxyisoquinolin-3-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one, DIMETHYL SULFOXIDE, IMIDAZOLE, ... | 著者 | Dougan, D.R, Lawson, J.D. | 登録日 | 2021-06-07 | 公開日 | 2021-09-08 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Discovery of the Bruton's Tyrosine Kinase Inhibitor Clinical Candidate TAK-020 ( S )-5-(1-((1-Acryloylpyrrolidin-3-yl)oxy)isoquinolin-3-yl)-2,4-dihydro-3 H -1,2,4-triazol-3-one, by Fragment-Based Drug Design. J.Med.Chem., 64, 2021
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7N5Y
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![BU of 7n5y by Molmil](/molmil-images/mine/7n5y) | Fragment-Based Drug Design of a Novel, Covalent Bruton's Tyrosine Kinase Inhibitor | 分子名称: | 5-(1-{[(3S)-1-propanoylpyrrolidin-3-yl]oxy}isoquinolin-3-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one, DIMETHYL SULFOXIDE, IMIDAZOLE, ... | 著者 | Dougan, D.R, Lawson, J.D. | 登録日 | 2021-06-07 | 公開日 | 2021-09-08 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Discovery of the Bruton's Tyrosine Kinase Inhibitor Clinical Candidate TAK-020 ( S )-5-(1-((1-Acryloylpyrrolidin-3-yl)oxy)isoquinolin-3-yl)-2,4-dihydro-3 H -1,2,4-triazol-3-one, by Fragment-Based Drug Design. J.Med.Chem., 64, 2021
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7AKW
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![BU of 7akw by Molmil](/molmil-images/mine/7akw) | Crystal structure of the viral rhodopsins chimera O1O2 | 分子名称: | EICOSANE, RETINAL, chimera of viral rhodopsins OLPVR1 and OLPVRII | 著者 | Kovalev, K, Zabelskii, D, Alekseev, A, Astashkin, R, Gordeliy, V. | 登録日 | 2020-10-02 | 公開日 | 2020-11-25 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Viral rhodopsins 1 are an unique family of light-gated cation channels. Nat Commun, 11, 2020
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7AKY
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![BU of 7aky by Molmil](/molmil-images/mine/7aky) | Crystal structure of the viral rhodopsin OLPVR1 in P21212 space group | 分子名称: | (2S)-2,3-dihydroxypropyl (9Z)-hexadec-9-enoate, EICOSANE, viral rhodopsin OLPVR1 | 著者 | Kovalev, K, Zabelskii, D, Alekseev, A, Astashkin, R, Gordeliy, V. | 登録日 | 2020-10-02 | 公開日 | 2020-11-25 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Viral rhodopsins 1 are an unique family of light-gated cation channels. Nat Commun, 11, 2020
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7Q3X
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![BU of 7q3x by Molmil](/molmil-images/mine/7q3x) | |
6FAT
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7PJK
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![BU of 7pjk by Molmil](/molmil-images/mine/7pjk) | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with a benzotriazole analog of thalidomide | 分子名称: | (3S)-3-(benzotriazol-2-yl)piperidine-2,6-dione, Cereblon isoform 4, ZINC ION | 著者 | Heim, C, Hartmann, M.D, Maiwald, S. | 登録日 | 2021-08-24 | 公開日 | 2022-03-16 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Replacing the phthalimide core in thalidomide with benzotriazole. J Enzyme Inhib Med Chem, 37, 2022
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7N1H
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![BU of 7n1h by Molmil](/molmil-images/mine/7n1h) | CryoEM structure of Venezuelan equine encephalitis virus VLP in complex with the LDLRAD3 receptor | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Capsid, ... | 著者 | Basore, K, Nelson, C.A, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2021-05-27 | 公開日 | 2021-10-13 | 最終更新日 | 2021-11-10 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Structure of Venezuelan equine encephalitis virus in complex with the LDLRAD3 receptor. Nature, 598, 2021
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7AKX
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![BU of 7akx by Molmil](/molmil-images/mine/7akx) | Crystal structure of the viral rhodopsin OLPVR1 in P1 space group | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, EICOSANE, OLEIC ACID, ... | 著者 | Kovalev, K, Zabelskii, D, Alekseev, A, Astashkin, R, Gordeliy, V. | 登録日 | 2020-10-02 | 公開日 | 2020-11-25 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Viral rhodopsins 1 are an unique family of light-gated cation channels. Nat Commun, 11, 2020
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6OQQ
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![BU of 6oqq by Molmil](/molmil-images/mine/6oqq) | Legionella pneumophila SidJ/Saccharomyces cerevisiae calmodulin complex | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE MONOPHOSPHATE, CALCIUM ION, ... | 著者 | Tomchick, D.R, Tagliabracci, V.S, Black, M, Osinski, A. | 登録日 | 2019-04-28 | 公開日 | 2019-05-15 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.102 Å) | 主引用文献 | Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases. Science, 364, 2019
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6F1H
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![BU of 6f1h by Molmil](/molmil-images/mine/6f1h) | C1rC1s complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-galactopyranose-(1-4)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Almitairi, J.O.M, Venkatraman Girija, U, Furze, C.M, Simpson-Gray, X, Badakshi, F, Marshall, J.E, Mitchell, D.A, Moody, P.C.E, Wallis, R. | 登録日 | 2017-11-22 | 公開日 | 2018-01-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (4.5 Å) | 主引用文献 | Structure of the C1r-C1s interaction of the C1 complex of complement activation. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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