6M3Z

X-ray structure of a Drosophila dopamine transporter with NET-like mutations (D121G/S426M/F471L) in milnacipran bound form

Summary for 6M3Z

• Entry DOI: 10.2210/pdb6m3z/pdb
• Related: 6M0F 6M0Z 6M2R 6M38
• Related PRD ID: PRD_900001
• Descriptor: Sodium-dependent dopamine transporter, CHOLESTEROL HEMISUCCINATE, CHOLESTEROL, ... (12 entities in total)
• Functional Keywords: neurotransmitter transporter, antibody fragment, membrane protein
• Biological source: Drosophila melanogaster (Fruit fly); More
• Total number of polymer chains: 3
• Total formula weight: 109146.75

Authors

Shabareesh, P.,Mallela, A.K.,Joseph, D.,Penmatsa, A. (deposition date: 2020-03-04, release date: 2021-02-17, Last modification date: 2023-11-29)

• Primary citation: Pidathala, S.,Mallela, A.K.,Joseph, D.,Penmatsa, A.; Structural basis of norepinephrine recognition and transport inhibition in neurotransmitter transporters.; Nat Commun, 12:2199-2199, 2021; PubMed: 33850134; DOI: 10.1038/s41467-021-22385-9

Experimental method

X-RAY DIFFRACTION (3.11 Å)