8EDE
Crystal structure of covalent inhibitor 2-chloro-N'-(N-(4-chlorophenyl)-N-methylglycyl)acetohydrazide bound to Ubiquitin C-terminal Hydrolase-L1
Summary for 8EDE
Entry DOI | 10.2210/pdb8ede/pdb |
Descriptor | Ubiquitin carboxyl-terminal hydrolase isozyme L1, 2-[(4-chlorophenyl)-methyl-amino]-~{N}'-ethanoyl-ethanehydrazide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | uchl1, deubiquitylating enzyme, inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 50606.34 |
Authors | Patel, R.,Imhoff, R.,Flaherty, D.,Das, C. (deposition date: 2022-09-04, release date: 2023-09-20, Last modification date: 2024-04-10) |
Primary citation | Imhoff, R.D.,Patel, R.,Safdar, M.H.,Jones, H.B.L.,Pinto-Fernandez, A.,Vendrell, I.,Chen, H.,Muli, C.S.,Krabill, A.D.,Kessler, B.M.,Wendt, M.K.,Das, C.,Flaherty, D.P. Covalent Fragment Screening and Optimization Identifies the Chloroacetohydrazide Scaffold as Inhibitors for Ubiquitin C-terminal Hydrolase L1. J.Med.Chem., 67:4496-4524, 2024 Cited by PubMed: 38488146DOI: 10.1021/acs.jmedchem.3c01661 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.799 Å) |
Structure validation
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