5JMD
| Heparinase III-BT4657 gene product, Methylated Lysines | 分子名称: | Heparinase III protein, MAGNESIUM ION | 著者 | Ulaganathan, T.S, Shi, R, Yao, D, Garron, M.-L, Cherney, M, Cygler, M. | 登録日 | 2016-04-28 | 公開日 | 2016-05-25 | 最終更新日 | 2018-01-17 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Conformational flexibility of PL12 family heparinases: structure and substrate specificity of heparinase III from Bacteroides thetaiotaomicron (BT4657). Glycobiology, 27, 2017
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6WI2
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6WIH
| N-terminal mutation of ISCU2 (L35H36) traps Nfs1 Cys loop in the active site of ISCU2 without metal present. Structure of human mitochondrial complex Nfs1-ISCU2(L35H36)-ISD11 with E.coli ACP1 at 1.9 A resolution (NIAU)2. | 分子名称: | 1,2-ETHANEDIOL, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, Acyl carrier protein, ... | 著者 | Boniecki, M.T, Cygler, M. | 登録日 | 2020-04-09 | 公開日 | 2020-05-13 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The essential function of ISCU2 and its conserved N-terminus in Fe/S cluster biogenesis To Be Published
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1CB8
| CHONDROITINASE AC LYASE FROM FLAVOBACTERIUM HEPARINUM | 分子名称: | CALCIUM ION, GLYCEROL, PROTEIN (CHONDROITINASE AC), ... | 著者 | Fethiere, J, Eggimann, B, Cygler, M. | 登録日 | 1999-03-02 | 公開日 | 1999-05-14 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of chondroitin AC lyase, a representative of a family of glycosaminoglycan degrading enzymes. J.Mol.Biol., 288, 1999
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1CIY
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7RTK
| Structure of the (NIAU)2 complex with N-terminal mutation of ISCU2 Y35D at 2.5 A resolution | 分子名称: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, ... | 著者 | Boniecki, M.T, Cygler, M. | 登録日 | 2021-08-13 | 公開日 | 2021-08-25 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The essential function of ISCU2 and its conserved N-terminus in Fe/S cluster biogenesis To Be Published
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5KDG
| Crystal Structure of Salmonella Typhimurium Effector GtgE | 分子名称: | GLYCEROL, Gifsy-2 prophage protein, SULFATE ION | 著者 | Kozlov, G, Xu, C, Wong, K, Gehring, K, Cygler, M, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) | 登録日 | 2016-06-08 | 公開日 | 2016-11-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Crystal Structure of the Salmonella Typhimurium Effector GtgE. PLoS ONE, 11, 2016
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6MCQ
| L. pneumophila effector kinase LegK7 in complex with human MOB1A | 分子名称: | DI(HYDROXYETHYL)ETHER, HEXAETHYLENE GLYCOL, LegK7, ... | 著者 | Beyrakhova, K.A, Xu, C, Boniecki, M.T, Cygler, M. | 登録日 | 2018-09-01 | 公開日 | 2019-09-04 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | TheLegionellakinase LegK7 exploits the Hippo pathway scaffold protein MOB1A for allostery and substrate phosphorylation. Proc.Natl.Acad.Sci.USA, 117, 2020
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6MCP
| L. pneumophila effector kinase LegK7 (AMP-PNP bound) in complex with human MOB1A | 分子名称: | DI(HYDROXYETHYL)ETHER, HEXAETHYLENE GLYCOL, LegK7, ... | 著者 | Beyrakhova, K.A, Xu, C, Boniecki, M.T, Cygler, M. | 登録日 | 2018-09-01 | 公開日 | 2019-09-04 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | TheLegionellakinase LegK7 exploits the Hippo pathway scaffold protein MOB1A for allostery and substrate phosphorylation. Proc.Natl.Acad.Sci.USA, 117, 2020
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5FIA
| Structure of the effector protein LpiR1 (Lpg0634) from Legionella pneumophila | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, LpiR1 | 著者 | Beyrakhova, K, van Straaten, K, Cygler, M. | 登録日 | 2015-12-22 | 公開日 | 2016-01-27 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structural and Functional Investigations of the Effector Protein LpiR1 from Legionella pneumophila. J.Biol.Chem., 291, 2016
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1DIB
| HUMAN METHYLENETETRAHYDROFOLATE DEHYDROGENASE / CYCLOHYDROLASE COMPLEXED WITH NADP AND INHIBITOR LY345899 | 分子名称: | 4-(7-AMINO-9-HYDROXY-1-OXO-3,3A,4,5-TETRAHYDRO-2,5,6,8,9B-PENTAAZA-CYCLOPENTA[A]NAPHTHALEN-2-YL)-PHENYLCARBONYL-GLUTAMI C ACID, METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Schmidt, A, Wu, H, MacKenzie, R.E, Chen, V.J, Bewly, J.R, Ray, J.E, Toth, J.E, Cygler, M. | 登録日 | 1999-11-29 | 公開日 | 2000-07-05 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase. Biochemistry, 39, 2000
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1DIA
| HUMAN METHYLENETETRAHYDROFOLATE DEHYDROGENASE / CYCLOHYDROLASE COMPLEXED WITH NADP AND INHIBITOR LY249543 | 分子名称: | METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [[[2-AMINO-5,6,7,8-TETRAHYDRO-4-HYDROXY-PYRIDO[2,3-D]PYRIMIDIN-6-YL]-ETHYL]-PHENYL]-CARBONYL-GLUTAMIC ACID | 著者 | Schmidt, A, Wu, H, MacKenzie, R.E, Chen, V.J, Bewly, J.R, Ray, J.E, Toth, J.E, Cygler, M. | 登録日 | 1999-11-29 | 公開日 | 2000-07-05 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase. Biochemistry, 39, 2000
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1DIG
| HUMAN METHYLENETETRAHYDROFOLATE DEHYDROGENASE / CYCLOHYDROLASE COMPLEXED WITH NADP AND INHIBITOR LY374571 | 分子名称: | ACETATE ION, METHYLENETETRAHYDROFOLATE DEHYDROGENASE / CYCLOHYDROLASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Schmidt, A, Wu, H, MacKenzie, R.E, Chen, V.J, Bewly, J.R, Ray, J.E, Toth, J.E, Cygler, M. | 登録日 | 1999-11-29 | 公開日 | 2000-07-05 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase. Biochemistry, 39, 2000
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5JG4
| Structure of the effector protein LpiR1 (Lpg0634) from Legionella pneumophila | 分子名称: | CITRATE ANION, GLYCEROL, PHOSPHATE ION, ... | 著者 | Beyrakhova, K, van Straaten, K, Cygler, M. | 登録日 | 2016-04-19 | 公開日 | 2016-05-04 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural and Functional Investigations of the Effector Protein LpiR1 from Legionella pneumophila. J.Biol.Chem., 291, 2016
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1A4I
| HUMAN TETRAHYDROFOLATE DEHYDROGENASE / CYCLOHYDROLASE | 分子名称: | METHYLENETETRAHYDROFOLATE DEHYDROGENASE / METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Allaire, M, Li, Y, Mackenzie, R.E, Cygler, M. | 登録日 | 1998-01-30 | 公開日 | 1999-02-09 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | The 3-D structure of a folate-dependent dehydrogenase/cyclohydrolase bifunctional enzyme at 1.5 A resolution. Structure, 6, 1998
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1CJL
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1THG
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4MU6
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4E2C
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4E2L
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4E2H
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4E29
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2ZL1
| MP1-p14 Scaffolding complex | 分子名称: | Mitogen-activated protein kinase kinase 1-interacting protein 1, Mitogen-activated protein-binding protein-interacting protein | 著者 | Schrag, J.D, Cygler, M, Munger, C, Magloire, A. | 登録日 | 2008-04-02 | 公開日 | 2008-06-24 | 最終更新日 | 2021-11-10 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Molecular dynamics-solvated interaction energy studies of protein-protein interactions: the MP1-p14 scaffolding complex. J.Mol.Biol., 379, 2008
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4EEC
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3B8N
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