3PJP
| A Tandem SH2 Domain in Transcription Elongation Factor Spt6 Binds the Phosphorylated RNA Polymerase II C-terminal Repeat Domain(CTD) | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACETATE ION, Transcription elongation factor SPT6 | Authors: | Sun, M, Lariviere, L, Dengl, S, Mayer, A, Cramer, P. | Deposit date: | 2010-11-10 | Release date: | 2010-11-24 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | A tandem SH2 domain in transcription elongation factor Spt6 binds the phosphorylated RNA polymerase II C-terminal repeat domain (CTD). J.Biol.Chem., 285, 2010
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5L3X
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3H3V
| Yeast RNAP II containing poly(A)-signal sequence in the active site | Descriptor: | 5'-D(*AP*GP*CP*TP*CP*AP*AP*GP*TP*AP*GP*CP*TP*GP*CP*TP*TP*TP*AP*TP*TP*GP*CP*AP*TP*T)-3', 5'-D(*CP*AP*GP*CP*TP*AP*CP*TP*TP*GP*AP*GP*CP*T)-3', 5'-R(*UP*GP*CP*AP*UP*UP*UP*CP*GP*CP*AP*AP*UP*AP*AP*A)-3', ... | Authors: | Dengl, S, Cramer, P. | Deposit date: | 2009-04-17 | Release date: | 2009-06-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Torpedo Nuclease Rat1 Is Insufficient to Terminate RNA Polymerase II in Vitro J.Biol.Chem., 284, 2009
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3SPA
| Crystal Structure of Human Mitochondrial RNA Polymerase | Descriptor: | CHLORIDE ION, DNA-directed RNA polymerase, mitochondrial, ... | Authors: | Ringel, R, Sologub, M, Morozov, Y.I, Litonin, D, Cramer, P, Temiakov, D. | Deposit date: | 2011-07-01 | Release date: | 2011-09-28 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of human mitochondrial RNA polymerase Nature, 478, 2011
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3HOU
| Complete RNA polymerase II elongation complex I with a T-U mismatch | Descriptor: | 5'-D(*A*AP*CP*TP*AP*CP*TP*TP*GP*AP*GP*CP*T)-3', 5'-D(*AP*GP*CP*TP*CP*A*AP*GP*TP*AP*GP*TP*TP*AP*TP*GP*CP*CP*(BRU)P*GP*GP*TP*CP*AP*TP*T)-3', 5'-R(*UP*GP*CP*AP*UP*U*UP*CP*GP*AP*CP*CP*AP*GP*GP*CP*U)-3', ... | Authors: | Sydow, J.F, Brueckner, F, Cheung, A.C.M, Damsma, G.E, Dengl, S, Lehmann, E, Vassylyev, D, Cramer, P. | Deposit date: | 2009-06-03 | Release date: | 2009-07-28 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural basis of transcription: mismatch-specific fidelity mechanisms and paused RNA polymerase II with frayed RNA. Mol.Cell, 34, 2009
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7OZV
| SARS-CoV-2 RdRp with Molnupiravir/ NHC in the template strand base-paired with G | Descriptor: | Non-structural protein 7, Non-structural protein 8, Product RNA, ... | Authors: | Kabinger, F, Stiller, C, Schmitzova, J, Dienemann, C, Kokic, G, Hillen, H.S, Hoebartner, C, Cramer, P. | Deposit date: | 2021-06-28 | Release date: | 2021-08-18 | Last modified: | 2021-09-29 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis. Nat.Struct.Mol.Biol., 28, 2021
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7OZU
| SARS-CoV-2 RdRp with Molnupiravir/ NHC in the template strand base-paired with A | Descriptor: | Non-structural protein 7, Non-structural protein 8, Product RNA, ... | Authors: | Kabinger, F, Stiller, C, Schmitzova, J, Dienemann, C, Kokic, G, Hillen, H.S, Hoebartner, C, Cramer, P. | Deposit date: | 2021-06-28 | Release date: | 2021-08-18 | Last modified: | 2021-09-29 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis. Nat.Struct.Mol.Biol., 28, 2021
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5OQM
| STRUCTURE OF YEAST TRANSCRIPTION PRE-INITIATION COMPLEX WITH TFIIH AND CORE MEDIATOR | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | Authors: | Schilbach, S, Hantsche, M, Tegunov, D, Dienemann, C, Wigge, C, Urlaub, H, Cramer, P. | Deposit date: | 2017-08-13 | Release date: | 2018-05-09 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (5.8 Å) | Cite: | Structures of transcription pre-initiation complex with TFIIH and Mediator. Nature, 551, 2017
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5OQJ
| STRUCTURE OF YEAST TRANSCRIPTION PRE-INITIATION COMPLEX WITH TFIIH | Descriptor: | DNA repair helicase RAD25, DNA repair helicase RAD3, DNA-directed RNA polymerase II subunit RPB1, ... | Authors: | Schilbach, S, Hantsche, M, Tegunov, D, Dienemann, C, Wigge, C, Henning, U, Cramer, P. | Deposit date: | 2017-08-11 | Release date: | 2018-04-25 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Structures of transcription pre-initiation complex with TFIIH and Mediator. Nature, 551, 2017
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3HOW
| Complete RNA polymerase II elongation complex III with a T-U mismatch and a frayed RNA 3'-uridine | Descriptor: | 5'-D(*AP*CP*TP*AP*CP*TP*TP*GP*AP*GP*CP*T)-3', 5'-D(*AP*GP*CP*TP*C*AP*AP*GP*TP*AP*GP*TP*TP*AP*TP*GP*CP*CP*(BRU)P*GP*GP*TP*CP*AP*TP*T)-3', 5'-R(*UP*GP*CP*AP*UP*UP*U*CP*AP*AP*CP*CP*AP*GP*GP*CP*UP*U)-3', ... | Authors: | Sydow, J.F, Brueckner, F, Cheung, A.C.M, Damsma, G.E, Dengl, S, Lehmann, E, Vassylyev, D, Cramer, P. | Deposit date: | 2009-06-03 | Release date: | 2009-07-28 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Structural basis of transcription: mismatch-specific fidelity mechanisms and paused RNA polymerase II with frayed RNA. Mol.Cell, 34, 2009
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5N5Y
| Cryo-EM structure of RNA polymerase I in complex with Rrn3 and Core Factor (Orientation III) | Descriptor: | DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... | Authors: | Engel, C, Gubbey, T, Neyer, S, Sainsbury, S, Oberthuer, C, Baejen, C, Bernecky, C, Cramer, P. | Deposit date: | 2017-02-14 | Release date: | 2017-04-05 | Last modified: | 2018-10-03 | Method: | ELECTRON MICROSCOPY (7.7 Å) | Cite: | Structural Basis of RNA Polymerase I Transcription Initiation. Cell, 169, 2017
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5O9G
| Structure of nucleosome-Chd1 complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Chromo domain-containing protein 1, ... | Authors: | Farnung, L, Vos, S.M, Wigge, C, Cramer, P. | Deposit date: | 2017-06-19 | Release date: | 2017-10-11 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | Nucleosome-Chd1 structure and implications for chromatin remodelling. Nature, 550, 2017
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7ONU
| Structure of human mitochondrial RNase P in complex with mitochondrial pre-tRNA-Tyr | Descriptor: | 3-hydroxyacyl-CoA dehydrogenase type-2, MAGNESIUM ION, Mitochondrial Precursor tRNA-Tyr, ... | Authors: | Bhatta, A, Dienemann, C, Cramer, P, Hillen, H.S. | Deposit date: | 2021-05-26 | Release date: | 2021-08-11 | Last modified: | 2021-09-29 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis of RNA processing by human mitochondrial RNase P. Nat.Struct.Mol.Biol., 28, 2021
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7OKX
| Structure of active transcription elongation complex Pol II-DSIF (SPT5-KOW5)-ELL2-EAF1 (composite structure) | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB1, ... | Authors: | Chen, Y, Vos, S.M, Dienemann, C, Ninov, M, Urlaub, H, Cramer, P. | Deposit date: | 2021-05-18 | Release date: | 2021-07-14 | Last modified: | 2021-09-01 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Allosteric transcription stimulation by RNA polymerase II super elongation complex. Mol.Cell, 81, 2021
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7OKY
| Structure of active transcription elongation complex Pol II-DSIF-ELL2-EAF1(composite structure) | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB1, ... | Authors: | Chen, Y, Vos, S.M, Dienemann, C, Ninov, M, Urlaub, H, Cramer, P. | Deposit date: | 2021-05-18 | Release date: | 2021-07-14 | Last modified: | 2021-09-01 | Method: | ELECTRON MICROSCOPY (4.14 Å) | Cite: | Allosteric transcription stimulation by RNA polymerase II super elongation complex. Mol.Cell, 81, 2021
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5N5Z
| Cryo-EM structure of RNA polymerase I in complex with Rrn3 and Core Factor (Orientation II) | Descriptor: | DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... | Authors: | Engel, C, Gubbey, T, Neyer, S, Sainsbury, S, Oberthuer, C, Baejen, C, Bernecky, C, Cramer, P. | Deposit date: | 2017-02-14 | Release date: | 2017-04-05 | Last modified: | 2018-10-03 | Method: | ELECTRON MICROSCOPY (7.7 Å) | Cite: | Structural Basis of RNA Polymerase I Transcription Initiation. Cell, 169, 2017
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5N60
| Cryo-EM structure of RNA polymerase I in complex with Rrn3 and Core Factor (Orientation I) | Descriptor: | DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... | Authors: | Engel, C, Gubbey, T, Neyer, S, Sainsbury, S, Oberthuer, C, Baejen, C, Bernecky, C, Cramer, P. | Deposit date: | 2017-02-14 | Release date: | 2017-04-05 | Last modified: | 2018-10-03 | Method: | ELECTRON MICROSCOPY (7.7 Å) | Cite: | Structural Basis of RNA Polymerase I Transcription Initiation. Cell, 169, 2017
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7OL0
| Structure of active transcription elongation complex Pol II-DSIF (SPT5-KOW5) | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB1, ... | Authors: | Chen, Y, Vos, S.M, Dienemann, C, Ninov, M, Urlaub, H, Cramer, P. | Deposit date: | 2021-05-18 | Release date: | 2021-07-14 | Last modified: | 2021-09-01 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Allosteric transcription stimulation by RNA polymerase II super elongation complex. Mol.Cell, 81, 2021
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7OOP
| Pol II-CSB-CSA-DDB1-UVSSA-PAF-SPT6 (Structure 3) | Descriptor: | DNA damage-binding protein 1, DNA excision repair protein ERCC-6, DNA excision repair protein ERCC-8, ... | Authors: | Kokic, G, Cramer, P. | Deposit date: | 2021-05-28 | Release date: | 2021-10-06 | Last modified: | 2021-10-27 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis of human transcription-DNA repair coupling. Nature, 598, 2021
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7OPD
| Pol II-CSB-CRL4CSA-UVSSA-SPT6-PAF (Structure 5) | Descriptor: | Cullin-4A, DNA damage-binding protein 1, DNA excision repair protein ERCC-6, ... | Authors: | Kokic, G, Cramer, P. | Deposit date: | 2021-05-31 | Release date: | 2021-10-06 | Last modified: | 2021-10-27 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis of human transcription-DNA repair coupling. Nature, 598, 2021
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7OO3
| Pol II-CSB-CSA-DDB1-UVSSA (Structure1) | Descriptor: | CSB element, DNA damage-binding protein 1, DNA excision repair protein ERCC-6, ... | Authors: | Kokic, G, Cramer, P. | Deposit date: | 2021-05-26 | Release date: | 2021-10-06 | Last modified: | 2021-10-27 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural basis of human transcription-DNA repair coupling. Nature, 598, 2021
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7OPC
| Pol II-CSB-CRL4CSA-UVSSA-SPT6-PAF (Structure 4) | Descriptor: | Cullin-4A, DNA damage-binding protein 1, DNA excision repair protein ERCC-6, ... | Authors: | Kokic, G, Cramer, P. | Deposit date: | 2021-05-31 | Release date: | 2021-10-13 | Last modified: | 2021-10-27 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis of human transcription-DNA repair coupling. Nature, 598, 2021
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7OOB
| Pol II-CSB-CSA-DDB1-UVSSA-ADPBeF3 (Structure2) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA damage-binding protein 1, ... | Authors: | Kokic, G, Cramer, P. | Deposit date: | 2021-05-27 | Release date: | 2021-10-13 | Last modified: | 2021-10-27 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural basis of human transcription-DNA repair coupling. Nature, 598, 2021
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7OYG
| Dimeric form of SARS-CoV-2 RNA-dependent RNA polymerase | Descriptor: | RNA (5'-R(P*CP*UP*AP*CP*GP*CP*AP*GP*UP*G)-3'), RNA (5'-R(P*UP*GP*CP*AP*CP*UP*GP*CP*GP*UP*AP*G)-3'), SARS-CoV-2 RNA-dependent RNA polymerase (nsp12), ... | Authors: | Jochheim, F.A, Tegunov, D, Hillen, H.S, Schmitzova, J, Kokic, G, Dienemann, C, Cramer, P. | Deposit date: | 2021-06-24 | Release date: | 2021-08-25 | Last modified: | 2021-09-01 | Method: | ELECTRON MICROSCOPY (5.5 Å) | Cite: | The structure of a dimeric form of SARS-CoV-2 polymerase Communications Biology, 4, 2021
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7PKS
| Structural basis of Integrator-mediated transcription regulation | Descriptor: | DNA Template, DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... | Authors: | Fianu, I, Chen, Y, Dienemann, C, Cramer, P. | Deposit date: | 2021-08-26 | Release date: | 2021-12-08 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural basis of Integrator-mediated transcription regulation. Science, 374, 2021
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