3ZNB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3znb by Molmil](/molmil-images/mine/3znb) | METALLO-BETA-LACTAMASE (ZN, HG-BOUND FORM) | 分子名称: | MERCURY (II) ION, METALLO-BETA-LACTAMASE, SODIUM ION, ... | 著者 | Concha, N.O, Herzberg, O. | 登録日 | 1997-10-15 | 公開日 | 1998-01-28 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal structures of the cadmium- and mercury-substituted metallo-beta-lactamase from Bacteroides fragilis. Protein Sci., 6, 1997
|
|
2ZNB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2znb by Molmil](/molmil-images/mine/2znb) | |
5DE1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5de1 by Molmil](/molmil-images/mine/5de1) | Crystal structure of human IDH1 in complex with GSK321A | 分子名称: | (7R)-1-(4-fluorobenzyl)-N-{3-[(1S)-1-hydroxyethyl]phenyl}-7-methyl-5-(1H-pyrrol-2-ylcarbonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-3-carboxamide, Isocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Concha, N.O, Smallwood, A, Qi, H. | 登録日 | 2015-08-25 | 公開日 | 2015-10-07 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | New IDH1 mutant inhibitors for treatment of acute myeloid leukemia. Nat.Chem.Biol., 11, 2015
|
|
7T0O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7t0o by Molmil](/molmil-images/mine/7t0o) | |
3D0E
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3d0e by Molmil](/molmil-images/mine/3d0e) | Crystal structure of human Akt2 in complex with GSK690693 | 分子名称: | 4-{2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-piperidin-3-ylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl}-2-methylbut-3-yn-2-ol, RAC-beta serine/threonine-protein kinase | 著者 | Concha, N.O, Smallwood, A. | 登録日 | 2008-05-01 | 公開日 | 2008-10-21 | 最終更新日 | 2017-10-25 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase. J.Med.Chem., 51, 2008
|
|
2RAN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2ran by Molmil](/molmil-images/mine/2ran) | RAT ANNEXIN V CRYSTAL STRUCTURE: CA2+-INDUCED CONFORMATIONAL CHANGES | 分子名称: | ANNEXIN V, CALCIUM ION, SULFATE ION | 著者 | Concha, N.O, Head, J.F, Kaetzel, M.A, Dedman, J.R, Seaton, B.A. | 登録日 | 1994-09-01 | 公開日 | 1994-11-30 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Rat annexin V crystal structure: Ca(2+)-induced conformational changes. Science, 261, 1993
|
|
2FVC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2fvc by Molmil](/molmil-images/mine/2fvc) | Crystal structure of NS5B BK strain (delta 24) in complex with a 3-(1,1-Dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinone | 分子名称: | 3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxy-1-(3-methylbutyl)quinolin-2(1H)-one, polyprotein | 著者 | Concha, N.O, Wonacott, A, Singh, O. | 登録日 | 2006-01-30 | 公開日 | 2007-01-16 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | 3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase. J.Med.Chem., 49, 2006
|
|
6NT2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6nt2 by Molmil](/molmil-images/mine/6nt2) | type 1 PRMT in complex with the inhibitor GSK3368715 | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, GLYCEROL, N~1~-({5-[4,4-bis(ethoxymethyl)cyclohexyl]-1H-pyrazol-4-yl}methyl)-N~1~,N~2~-dimethylethane-1,2-diamine, ... | 著者 | Concha, N.O. | 登録日 | 2019-01-28 | 公開日 | 2019-07-10 | 最終更新日 | 2019-07-24 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss. Cancer Cell, 36, 2019
|
|
4YZD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4yzd by Molmil](/molmil-images/mine/4yzd) | |
6DXL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6dxl by Molmil](/molmil-images/mine/6dxl) | Linked amidobenzimidazole STING agonist | 分子名称: | 1,1'-(butane-1,4-diyl)bis{2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-1H-benzimidazole-5-carboxamide}, CALCIUM ION, Stimulator of interferon protein | 著者 | Concha, N.O. | 登録日 | 2018-06-29 | 公開日 | 2018-11-07 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Design of amidobenzimidazole STING receptor agonists with systemic activity. Nature, 564, 2018
|
|
6DXG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6dxg by Molmil](/molmil-images/mine/6dxg) | amidobenzimidazole (ABZI) STING agonists | 分子名称: | 2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-1-[(2R)-2-hydroxy-2-phenylethyl]-1H-benzimidazole-5-carboxamide, CALCIUM ION, Stimulator of interferon protein | 著者 | Concha, N.O. | 登録日 | 2018-06-28 | 公開日 | 2018-11-07 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.905 Å) | 主引用文献 | Design of amidobenzimidazole STING receptor agonists with systemic activity. Nature, 564, 2018
|
|
1ZNB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1znb by Molmil](/molmil-images/mine/1znb) | METALLO-BETA-LACTAMASE | 分子名称: | METALLO-BETA-LACTAMASE, SODIUM ION, ZINC ION | 著者 | Concha, N.O, Herzberg, O. | 登録日 | 1996-06-06 | 公開日 | 1997-01-11 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Crystal structure of the wide-spectrum binuclear zinc beta-lactamase from Bacteroides fragilis. Structure, 4, 1996
|
|
4YZC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4yzc by Molmil](/molmil-images/mine/4yzc) | |
4YZ9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4yz9 by Molmil](/molmil-images/mine/4yz9) | |
5KH5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5kh5 by Molmil](/molmil-images/mine/5kh5) | |
5KH4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5kh4 by Molmil](/molmil-images/mine/5kh4) | |
5KH2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5kh2 by Molmil](/molmil-images/mine/5kh2) | |
4L04
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4l04 by Molmil](/molmil-images/mine/4l04) | |
3HHK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3hhk by Molmil](/molmil-images/mine/3hhk) | HCV NS5b polymerase complex with a substituted benzothiadizine | 分子名称: | 2-({(3R)-3-[(3S)-1-(3-methylbutyl)-2,4-dioxo-1,2,3,4-tetrahydroquinolin-3-yl]-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl}oxy)acetamide, HCV NS5 polymerase | 著者 | Concha, N.O, Singh, O. | 登録日 | 2009-05-15 | 公開日 | 2009-09-08 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase. Bioorg.Med.Chem.Lett., 19, 2009
|
|
4L03
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4l03 by Molmil](/molmil-images/mine/4l03) | |
4KZO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4kzo by Molmil](/molmil-images/mine/4kzo) | |
4L06
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4l06 by Molmil](/molmil-images/mine/4l06) | |
8UIF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8uif by Molmil](/molmil-images/mine/8uif) | |
8UIA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8uia by Molmil](/molmil-images/mine/8uia) | |
8UHO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8uho by Molmil](/molmil-images/mine/8uho) | |