3HHK

HCV NS5b polymerase complex with a substituted benzothiadizine

Summary for 3HHK

• Entry DOI: 10.2210/pdb3hhk/pdb
• Descriptor: HCV NS5 polymerase, 2-({(3R)-3-[(3S)-1-(3-methylbutyl)-2,4-dioxo-1,2,3,4-tetrahydroquinolin-3-yl]-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl}oxy)acetamide (3 entities in total)
• Functional Keywords: ns5b, polymerase, hcv, inhhibitor, atp-binding, envelope protein, helicase, hydrolase, membrane, nucleotide-binding, rna replication, transmembrane, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Hepatitis C virus subtype 1b
• Cellular location: Virion : Q99AU2
• Total number of polymer chains: 2
• Total formula weight: 125842.18

Authors

Concha, N.O.,Singh, O. (deposition date: 2009-05-15, release date: 2009-09-08, Last modification date: 2024-02-21)

• Primary citation: Shaw, A.N.,Tedesco, R.,Bambal, R.,Chai, D.,Concha, N.O.,Darcy, M.G.,Dhanak, D.,Duffy, K.J.,Fitch, D.M.,Gates, A.,Johnston, V.K.,Keenan, R.M.,Lin-Goerke, J.,Liu, N.,Sarisky, R.T.,Wiggall, K.J.,Zimmerman, M.N.; Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase.; Bioorg.Med.Chem.Lett., 19:4350-4353, 2009; PubMed: 19515564; DOI: 10.1016/j.bmcl.2009.05.091

Experimental method

X-RAY DIFFRACTION (1.7 Å)