5AJJ
 
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3ZLO
 | | Crystal structure of BCL-XL in complex with inhibitor (Compound 6) | | 分子名称: | 2-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]-5-(4-phenylbutyl)-1,3-thiazole-4-carboxylic acid, BCL-2-LIKE PROTEIN 1 | | 著者 | Czabotar, P.E, Lessene, G.L, Smith, B.J, Colman, P.M. | | 登録日 | 2013-02-04 | | 公開日 | 2013-04-24 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.601 Å) | | 主引用文献 | Structure-Guided Design of a Selective Bcl-Xl Inhibitor
Nat.Chem.Biol., 9, 2013
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3ZLN
 | | Crystal structure of BCL-XL in complex with inhibitor (Compound 3) | | 分子名称: | 1,2-ETHANEDIOL, 6-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]pyridine-2-carboxylic acid, BCL-2-LIKE PROTEIN 1, ... | | 著者 | Czabotar, P.E, Lessene, G.L, Smith, B.J, Colman, P.M. | | 登録日 | 2013-02-04 | | 公開日 | 2013-04-24 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.288 Å) | | 主引用文献 | Structure-Guided Design of a Selective Bcl-Xl Inhibitor
Nat.Chem.Biol., 9, 2013
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3ZK6
 | | Crystal structure of Bcl-xL in complex with inhibitor (Compound 2). | | 分子名称: | BCL-2-LIKE PROTEIN 1, N-(3-(5-(1-(2-(benzo[d]thiazol-2-yl)hydrazono)ethyl)furan-2-yl)phenylsulfonyl)-6-phenylhexanamide | | 著者 | Czabotar, P.E, Lessene, G.L, Smith, B.J, Colman, P.M. | | 登録日 | 2013-01-22 | | 公開日 | 2013-04-24 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | | 主引用文献 | Structure-Guided Design of a Selective Bcl-Xl Inhibitor
Nat.Chem.Biol., 9, 2013
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3ZLR
 | | Crystal structure of BCL-XL in complex with inhibitor (WEHI-539) | | 分子名称: | 1,2-ETHANEDIOL, 5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]-1,3-thiazole-4-carboxylic acid, BCL-2-LIKE PROTEIN 1, ... | | 著者 | Czabotar, P.E, Lessene, G.L, Smith, B.J, Colman, P.M. | | 登録日 | 2013-02-04 | | 公開日 | 2013-04-24 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.026 Å) | | 主引用文献 | Structure-Guided Design of a Selective Bcl-Xl Inhibitor
Nat.Chem.Biol., 9, 2013
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1NMB
 | | THE STRUCTURE OF A COMPLEX BETWEEN THE NC10 ANTIBODY AND INFLUENZA VIRUS NEURAMINIDASE AND COMPARISON WITH THE OVERLAPPING BINDING SITE OF THE NC41 ANTIBODY | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, FAB NC10, ... | | 著者 | Malby, R.L, Tulip, W.R, Colman, P.M. | | 登録日 | 1995-01-17 | | 公開日 | 1995-09-15 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The structure of a complex between the NC10 antibody and influenza virus neuraminidase and comparison with the overlapping binding site of the NC41 antibody
Structure, 2, 1994
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5VX0
 | | Bak in complex with Bim-h3Glg | | 分子名称: | 1,2-ETHANEDIOL, Bcl-2 homologous antagonist/killer, Bcl-2-like protein 11, ... | | 著者 | Brouwer, J.M, Lan, P, Lessene, G, Colman, P.M, Czabotar, P.E. | | 登録日 | 2017-05-23 | | 公開日 | 2017-11-15 | | 最終更新日 | 2020-01-08 | | 実験手法 | X-RAY DIFFRACTION (1.599 Å) | | 主引用文献 | Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017
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5VX3
 | | Bcl-xL in complex with Bim-h3Pc-RT | | 分子名称: | 1,2-ETHANEDIOL, Bcl-2-like protein 1, Bcl-2-like protein 11 | | 著者 | Cowan, A.D, Brouwer, J.M, Colman, P.M, Czabotar, P.E. | | 登録日 | 2017-05-23 | | 公開日 | 2017-11-15 | | 最終更新日 | 2020-01-08 | | 実験手法 | X-RAY DIFFRACTION (1.945 Å) | | 主引用文献 | Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017
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5VWX
 | | Bak core latch dimer in complex with Bim-h0-h3Glt | | 分子名称: | 1,2-ETHANEDIOL, Bcl-2 homologous antagonist/killer, Bcl-2-like protein 11 | | 著者 | Brouwer, J.M, Lan, P, Lessene, G, Colman, P.M, Czabotar, P.E. | | 登録日 | 2017-05-23 | | 公開日 | 2017-11-15 | | 最終更新日 | 2020-01-08 | | 実験手法 | X-RAY DIFFRACTION (2.489 Å) | | 主引用文献 | Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017
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1L7F
 | | Crystal structure of influenza virus neuraminidase in complex with BCX-1812 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(1-ACETYLAMINO-2-ETHYL-BUTYL)-4-GUANIDINO-2-HYDROXY-CYCLOPENTANECARBOXYLIC ACID, ... | | 著者 | Smith, B.J, McKimm-Breshkin, J.L, McDonald, M, Fernley, R.T, Varghese, J.N, Colman, P.M. | | 登録日 | 2002-03-15 | | 公開日 | 2002-05-29 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural studies of the resistance of influenza virus neuramindase to inhibitors.
J.Med.Chem., 45, 2002
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5VWV
 | | Bak core latch dimer in complex with Bim-BH3 - Cubic | | 分子名称: | 1,2-ETHANEDIOL, Bcl-2 homologous antagonist/killer, Bcl-2-like protein 11, ... | | 著者 | Brouwer, J.M, Colman, P.M, Czabotar, P.E. | | 登録日 | 2017-05-23 | | 公開日 | 2017-11-15 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.897 Å) | | 主引用文献 | Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017
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5VX2
 | | Mcl-1 in complex with Bim-h3Pc-RT | | 分子名称: | 1,2-ETHANEDIOL, Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1 homolog,Induced myeloid leukemia cell differentiation protein Mcl-1 chimera | | 著者 | Cowan, A.D, Brouwer, J.M, Colman, P.M, Czabotar, P.E. | | 登録日 | 2017-05-23 | | 公開日 | 2017-11-15 | | 最終更新日 | 2020-01-08 | | 実験手法 | X-RAY DIFFRACTION (1.851 Å) | | 主引用文献 | Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017
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5VX1
 | | Bak L100A | | 分子名称: | Bcl-2 homologous antagonist/killer | | 著者 | Brouwer, J.M, Colman, P.M, Czabotar, P.E. | | 登録日 | 2017-05-23 | | 公開日 | 2017-11-15 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.224 Å) | | 主引用文献 | Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017
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5VWW
 | | Bak core latch dimer in complex with Bim-RT - Tetragonal | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, BROMIDE ION, Bcl-2 homologous antagonist/killer, ... | | 著者 | Brouwer, J.M, Colman, P.M, Czabotar, P.E. | | 登録日 | 2017-05-23 | | 公開日 | 2017-11-15 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.802 Å) | | 主引用文献 | Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017
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5VWZ
 | | Bak in complex with Bim-h3Pc | | 分子名称: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, AMMONIUM ION, Bcl-2 homologous antagonist/killer, ... | | 著者 | Brouwer, J.M, Colman, P.M, Czabotar, P.E. | | 登録日 | 2017-05-23 | | 公開日 | 2017-11-15 | | 最終更新日 | 2020-01-08 | | 実験手法 | X-RAY DIFFRACTION (1.622 Å) | | 主引用文献 | Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017
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5VWY
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5W5X
 | | Crystal structure of BAXP168G in complex with an activating antibody | | 分子名称: | 1,2-ETHANEDIOL, 3C10 Fab' heavy chain, 3C10 Fab' light chain, ... | | 著者 | Robin, A.Y, Colman, P.M, Czabotar, P.E. | | 登録日 | 2017-06-16 | | 公開日 | 2018-06-27 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.502 Å) | | 主引用文献 | Ensemble Properties of Bax Determine Its Function.
Structure, 26, 2018
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4BD8
 | | Bax domain swapped dimer induced by BimBH3 with CHAPS | | 分子名称: | 1,2-ETHANEDIOL, APOPTOSIS REGULATOR BAX, PRASEODYMIUM ION | | 著者 | Czabotar, P.E, Westphal, D, Adams, J.M, Colman, P.M. | | 登録日 | 2012-10-05 | | 公開日 | 2013-02-13 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Cell(Cambridge,Mass.), 152, 2013
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4BD2
 | | Bax domain swapped dimer in complex with BidBH3 | | 分子名称: | APOPTOSIS REGULATOR BAX, BH3-INTERACTING DOMAIN DEATH AGONIST | | 著者 | Czabotar, P.E, Westphal, D, Adams, J.M, Colman, P.M. | | 登録日 | 2012-10-04 | | 公開日 | 2013-02-13 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.206 Å) | | 主引用文献 | Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Cell(Cambridge,Mass.), 152, 2013
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3VPP
 | | Crystal Structure of the Human CLEC9A C-type Lectin-Like Domain | | 分子名称: | C-type lectin domain family 9 member A, CALCIUM ION | | 著者 | Czabotar, P.E, Zhang, J.G, Policheni, A.N, Shortman, K, Lahoud, M.H, Colman, P.M. | | 登録日 | 2012-03-07 | | 公開日 | 2012-04-25 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.642 Å) | | 主引用文献 | The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments.
Immunity, 36, 2012
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4A1W
 | | Crystal structure of alpha-beta foldamer 4c in complex with Bcl-xL | | 分子名称: | ALPHA-BETA-FOLDAMER 2C, BCL-2-LIKE PROTEIN 1 | | 著者 | Boersma, M.D, Haase, H.S, Kaufman, K.J, Horne, W.S, Lee, E.F, Clarke, O.B, Smith, B.J, Colman, P.M, Gellman, S.H, Fairlie, W.D. | | 登録日 | 2011-09-20 | | 公開日 | 2011-12-28 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.497 Å) | | 主引用文献 | Evaluation of Diverse Alpha/Beta-Backbone Patterns for Functional Alpha-Helix Mimicry: Analogues of the Bim Bh3 Domain.
J.Am.Chem.Soc., 134, 2012
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4BDU
 | | Bax BH3-in-Groove dimer (GFP) | | 分子名称: | GREEN FLUORESCENT PROTEIN, APOPTOSIS REGULATOR BAX | | 著者 | Czabotar, P.E, Colman, P.M. | | 登録日 | 2012-10-08 | | 公開日 | 2013-02-13 | | 最終更新日 | 2019-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.998 Å) | | 主引用文献 | Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Cell(Cambridge,Mass.), 152, 2013
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4BD6
 | | Bax domain swapped dimer in complex with BaxBH3 | | 分子名称: | APOPTOSIS REGULATOR BAX | | 著者 | Czabotar, P.E, Westphal, D, Adams, J.M, Colman, P.M. | | 登録日 | 2012-10-05 | | 公開日 | 2013-02-13 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.494 Å) | | 主引用文献 | Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Cell(Cambridge,Mass.), 152, 2013
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5W62
 | | Crystal structure of mouse BAX monomer | | 分子名称: | Apoptosis regulator BAX, SULFATE ION | | 著者 | Robin, A.Y, Colman, P.M, Czabotar, P.E, Luo, C.S. | | 登録日 | 2017-06-16 | | 公開日 | 2018-06-27 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.196 Å) | | 主引用文献 | Ensemble Properties of Bax Determine Its Function.
Structure, 26, 2018
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5W5Z
 | | Crystal structure of BAXP168G in complex with an activating antibody at high resolution | | 分子名称: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3C10 Fab heavy chain, ... | | 著者 | Robin, A.Y, Colman, P.M, Czabotar, P.E. | | 登録日 | 2017-06-16 | | 公開日 | 2018-06-27 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.997 Å) | | 主引用文献 | Ensemble Properties of Bax Determine Its Function.
Structure, 26, 2018
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