1NMB

THE STRUCTURE OF A COMPLEX BETWEEN THE NC10 ANTIBODY AND INFLUENZA VIRUS NEURAMINIDASE AND COMPARISON WITH THE OVERLAPPING BINDING SITE OF THE NC41 ANTIBODY

Summary for 1NMB

• Entry DOI: 10.2210/pdb1nmb/pdb
• Descriptor: N9 NEURAMINIDASE, FAB NC10, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: complex (hydrolase-immunoglobulin), complex (hydrolase-immunoglobulin) complex, complex (hydrolase/immunoglobulin)
• Biological source: Influenza A virus; More
• Total number of polymer chains: 3
• Total formula weight: 79713.03

Authors

Malby, R.L.,Tulip, W.R.,Colman, P.M. (deposition date: 1995-01-17, release date: 1995-09-15, Last modification date: 2024-10-16)

Primary citation

Malby, R.L.,Tulip, W.R.,Harley, V.R.,McKimm-Breschkin, J.L.,Laver, W.G.,Webster, R.G.,Colman, P.M.
The structure of a complex between the NC10 antibody and influenza virus neuraminidase and comparison with the overlapping binding site of the NC41 antibody
Structure, 2:733-746, 1994

PubMed Abstract: While it is well known that different antibodies can be produced against a particular antigen, and even against a particular site on an antigen, up until now there have been no structural studies of cross-reacting antibodies of this type. One antibody-antigen complex whose structure is known is that of the influenza virus antigen, neuraminidase, in complex with the NC41 antibody. Another anti-neuraminidase antibody, NC10, binds to an overlapping site on the antigen. The structure of the complex formed by this antibody with neuraminidase is described here and compared with the NC41-containing complex.

PubMed: 7994573
DOI: 10.1016/S0969-2126(00)00074-5

Experimental method

X-RAY DIFFRACTION (2.2 Å)