8P6H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8p6h by Molmil](/molmil-images/mine/8p6h) | Bovine naive ultralong antibody AbBLV5B8* collected at 100K | 分子名称: | Antibody BLV5B8* heavy chain, Antibody BLV5B8* light chain | 著者 | Clarke, J.D, Douangamath, A, Mikolajek, H, Stuart, D.I, Owens, R.J. | 登録日 | 2023-05-26 | 公開日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | The impact of chain-exchange on bovine ultralong immunoglobulins. Acta Crystallographica Section F, 2023
|
|
8P2T
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8p2t by Molmil](/molmil-images/mine/8p2t) | Bovine naive ultralong antibody AbD08* collected at 100K | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, Antibody D08* heavy chain, Antibody D08* light chain, ... | 著者 | Clarke, J.D, Douangamath, A, Mikolajek, H, Stuart, D.I, Owens, R.J. | 登録日 | 2023-05-16 | 公開日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | The impact of chain-exchange on bovine ultralong immunoglobulins. Acta Crystallographica Section F, 2024
|
|
8BS8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8bs8 by Molmil](/molmil-images/mine/8bs8) | Bovine naive ultralong antibody AbD08 collected at 100K | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Heavy chain, Light chain | 著者 | Clarke, J.D, Douangamath, A, Mikolajek, H, Stuart, D.I, Owens, R.J. | 登録日 | 2022-11-24 | 公開日 | 2023-05-24 | 最終更新日 | 2024-07-17 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | The impact of exchanging the light and heavy chains on the structures of bovine ultralong antibodies. Acta Crystallogr.,Sect.F, 80, 2024
|
|
1BNF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1bnf by Molmil](/molmil-images/mine/1bnf) | |
1BNE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1bne by Molmil](/molmil-images/mine/1bne) | |
1BNG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1bng by Molmil](/molmil-images/mine/1bng) | |
8CIF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8cif by Molmil](/molmil-images/mine/8cif) | Bovine naive ultralong antibody AbD08 collected at 293K | 分子名称: | Heavy chain, Light chain | 著者 | Clarke, J.D, Mikolajek, H, Stuart, D.I, Owens, R.J. | 登録日 | 2023-02-09 | 公開日 | 2023-05-24 | 最終更新日 | 2023-07-19 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Protein-to-structure pipeline for ambient-temperature in situ crystallography at VMXi. Iucrj, 10, 2023
|
|
1YQO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1yqo by Molmil](/molmil-images/mine/1yqo) | T268A mutant heme domain of flavocytochrome P450 BM3 | 分子名称: | Bifunctional P-450:NADPH-P450 reductase, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Clark, J.P, Miles, C.S, Mowat, C.G, Walkinshaw, M.D, Reid, G.A, Daff, S.N, Chapman, S.K. | 登録日 | 2005-02-02 | 公開日 | 2006-01-31 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The role of Thr268 and Phe393 in cytochrome P450 BM3. J.Inorg.Biochem., 100, 2006
|
|
1YQP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1yqp by Molmil](/molmil-images/mine/1yqp) | T268N mutant cytochrome domain of flavocytochrome P450 BM3 | 分子名称: | Bifunctional P-450:NADPH-P450 reductase, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Clark, J.P, Miles, C.S, Mowat, C.G, Walkinshaw, M.D, Reid, G.A, Daff, S.N, Chapman, S.K. | 登録日 | 2005-02-02 | 公開日 | 2006-01-31 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | The role of Thr268 and Phe393 in cytochrome P450 BM3. J.Inorg.Biochem., 100, 2006
|
|
2NNB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2nnb by Molmil](/molmil-images/mine/2nnb) | The Q403K mutant heme domain of flavocytochrome P450 BM3 | 分子名称: | Bifunctional P-450:NADPH-P450 reductase, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Clark, J.P, Anderson, J.L.R, Miles, C.S, Mowat, C.G, Reid, G.A, Chapman, S.K. | 登録日 | 2006-10-24 | 公開日 | 2007-09-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The Q403K mutant heme domain of flavocytochrome P450 BM3 To be published
|
|
6FAJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6faj by Molmil](/molmil-images/mine/6faj) | The structure of Human Methionine Adenosyltransferase II in apo state | 分子名称: | ACETATE ION, DI(HYDROXYETHYL)ETHER, S-adenosylmethionine synthase isoform type-2, ... | 著者 | Bradley-Clarke, J, Panmanee, J, Antonyuk, S.V, Hasnain, S.S. | 登録日 | 2017-12-15 | 公開日 | 2019-02-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory beta subunit and quinolone-based compounds Febs J., 2020
|
|
6GT3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6gt3 by Molmil](/molmil-images/mine/6gt3) | Crystal Structure of the A2A-StaR2-bRIL562 in complex with AZD4635 at 2.0A resolution | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 6-(2-chloranyl-6-methyl-pyridin-4-yl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine, Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, ... | 著者 | Borodovsky, A, Wang, Y, Deng, N, Ye, M, Stephen, T.L, Goodwin, K, Goodwin, R, Strittmatter, N, Shaw, J, Sachsenmeier, K, Clarke, J.D, Hay, C, Reimer, C, Andrews, S.P, Brown, G.A, Congreve, M, Cheng, R.K.Y, Dore, A.S, Mason, J.S, Marshall, F.H, Weir, M.P, Lyne, P, Woessner, R. | 登録日 | 2018-06-15 | 公開日 | 2019-06-26 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Small molecule AZD4635 inhibitor of A2AR signaling rescues immune cell function including CD103+ dendritic cells enhancing anti-tumor immunity J Immunother Cancer, 2020
|
|
5OD5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5od5 by Molmil](/molmil-images/mine/5od5) | Periplasmic binding protein CeuE complexed with a synthetic catalyst | 分子名称: | 2,5,8,11,14,17,20,23-OCTAOXAPENTACOSAN-25-OL, 4-(aminomethyl)-~{N}-(pyridin-2-ylmethyl)benzenesulfonamide, Azotochelin, ... | 著者 | Duhme-Klair, A.K, Raines, D.J, Clarke, J.E, Blagova, E.V, Dodson, E.J, Wilson, K.S. | 登録日 | 2017-07-04 | 公開日 | 2018-08-01 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Redox-switchable siderophore anchor enables reversible artificial metalloenzyme assembly Nat Catal, 2018
|
|
8A32
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8a32 by Molmil](/molmil-images/mine/8a32) | p53 cancer mutant Y220C in complex with iodophenol-based small-molecule stabilizer JC769 | 分子名称: | 1,2-ETHANEDIOL, 4-[3,4-bis(fluoranyl)pyrrol-1-yl]-3,5-bis(iodanyl)-2-oxidanyl-benzoic acid, Cellular tumor antigen p53, ... | 著者 | Balourdas, D.I, Stephenson Clarke, J.R, Baud, M.G.J, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC) | 登録日 | 2022-06-06 | 公開日 | 2022-11-30 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Discovery of Nanomolar-Affinity Pharmacological Chaperones Stabilizing the Oncogenic p53 Mutant Y220C. Acs Pharmacol Transl Sci, 5, 2022
|
|
5M6S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5m6s by Molmil](/molmil-images/mine/5m6s) | |
8A31
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8a31 by Molmil](/molmil-images/mine/8a31) | p53 cancer mutant Y220C in complex with iodophenol-based small-molecule stabilizer JC694 | 分子名称: | 4-(3-fluoranylpyrrol-1-yl)-3,5-bis(iodanyl)-2-oxidanyl-benzoic acid, Cellular tumor antigen p53, GLYCEROL, ... | 著者 | Balourdas, D.I, Stephenson Clarke, J.R, Baud, M.G.J, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC) | 登録日 | 2022-06-06 | 公開日 | 2022-11-30 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | Discovery of Nanomolar-Affinity Pharmacological Chaperones Stabilizing the Oncogenic p53 Mutant Y220C. Acs Pharmacol Transl Sci, 5, 2022
|
|
5C2N
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5c2n by Molmil](/molmil-images/mine/5c2n) | The de novo evolutionary emergence of a symmetrical protein is shaped by folding constraints | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta propeller | 著者 | Smock, R.G, Yadid, I, Dym, O, Clarke, J, Tawfik, D.S. | 登録日 | 2015-06-16 | 公開日 | 2016-01-20 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints. Cell, 164, 2016
|
|
2CK2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2ck2 by Molmil](/molmil-images/mine/2ck2) | Structure of core-swapped mutant of fibronectin | 分子名称: | ACETYL GROUP, HUMAN FIBRONECTIN | 著者 | Ng, S.P, Billings, K.S, Ohashi, T, Allen, M.D, Best, R.B, Randles, L.G, Erickson, H.P, Clarke, J. | 登録日 | 2006-04-10 | 公開日 | 2007-04-10 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Designing an Extracellular Matrix Protein with Enhanced Mechanical Stability Proc.Natl.Acad.Sci.USA, 104, 2007
|
|
5C2M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5c2m by Molmil](/molmil-images/mine/5c2m) | The de novo evolutionary emergence of a symmetrical protein is shaped by folding constraints | 分子名称: | Predicted protein | 著者 | Smock, R.G, Yadid, I, Dym, O, Clarke, J, Tawfik, D.S. | 登録日 | 2015-06-16 | 公開日 | 2016-02-03 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints. Cell, 164, 2016
|
|
6STJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6stj by Molmil](/molmil-images/mine/6stj) | Selective Affimers Recognize BCL-2 Family Proteins Through Non-Canonical Structural Motifs | 分子名称: | Cystatin domain-containing protein, Induced myeloid leukemia cell differentiation protein Mcl-1 | 著者 | Hobor, F, Miles, J.A, Trinh, C.H, Taylor, J, Tiede, C, Rowell, P.R, Jackson, B, Nadat, F, Kyle, H.F, Wicky, B.I.M, Clarke, J, Tomlinson, D.C, Wilson, A.J, Edwards, T.A. | 登録日 | 2019-09-10 | 公開日 | 2020-09-30 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Selective Affimers Recognise the BCL-2 Family Proteins BCL-x L and MCL-1 through Noncanonical Structural Motifs*. Chembiochem, 22, 2021
|
|
6ST2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6st2 by Molmil](/molmil-images/mine/6st2) | Selective Affimers Recognize BCL-2 Family Proteins Through Non-Canonical Structural Motifs | 分子名称: | Affimer AF6, Bcl-2-like protein 1, SULFATE ION | 著者 | Hobor, F, Miles, J.A, Trinh, C.H, Taylor, J, Tiede, C, Rowell, P.R, Jackson, B, Nadat, F, Kyle, H.F, Wicky, B.I.M, Clarke, J, Tomlinson, D.C, Wilson, A.J, Edwards, T.A. | 登録日 | 2019-09-09 | 公開日 | 2020-09-30 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Selective Affimers Recognise the BCL-2 Family Proteins BCL-x L and MCL-1 through Noncanonical Structural Motifs*. Chembiochem, 22, 2021
|
|
4P86
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4p86 by Molmil](/molmil-images/mine/4p86) | Structure of PyrR protein from Bacillus subtilis with GMP | 分子名称: | Bifunctional protein PyrR, GLYCEROL, GUANOSINE-5'-MONOPHOSPHATE | 著者 | Perica, T, Kondo, Y, Tiwari, S, McLaughlin, S, Steward, A, Reuter, N, Clarke, J, Teichmann, S.A. | 登録日 | 2014-03-30 | 公開日 | 2014-12-17 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Evolution of oligomeric state through allosteric pathways that mimic ligand binding. Science, 346, 2014
|
|
4P81
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4p81 by Molmil](/molmil-images/mine/4p81) | Structure of ancestral PyrR protein (AncORANGEPyrR) | 分子名称: | Ancestral PyrR protein (Orange), GLYCEROL, SULFATE ION | 著者 | Perica, T, Kondo, Y, Tiwari, S, McLaughlin, S, Steward, A, Reuter, N, Clarke, J, Teichmann, S.A. | 登録日 | 2014-03-29 | 公開日 | 2014-12-17 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Evolution of oligomeric state through allosteric pathways that mimic ligand binding. Science, 346, 2014
|
|
4P83
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4p83 by Molmil](/molmil-images/mine/4p83) | Structure of engineered PyrR protein (PURPLE PyrR) | 分子名称: | Engineered PyrR protein (Purple), URIDINE-5'-MONOPHOSPHATE | 著者 | Perica, T, Kondo, Y, Tiwari, S, McLaughlin, S, Steward, A, Reuter, N, Clarke, J, Teichmann, S.A. | 登録日 | 2014-03-30 | 公開日 | 2014-12-17 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Evolution of oligomeric state through allosteric pathways that mimic ligand binding. Science, 346, 2014
|
|
4P3K
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4p3k by Molmil](/molmil-images/mine/4p3k) | Structure of ancestral PyrR protein (PLUMPyrR) | 分子名称: | Ancestral PyrR protein (Plum), PENTAETHYLENE GLYCOL, SODIUM ION, ... | 著者 | Perica, T, Kondo, Y, Tiwari, S, McLaughlin, S, Steward, A, Reuter, N, Clarke, J, Teichmann, S.A. | 登録日 | 2014-03-08 | 公開日 | 2014-12-17 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Evolution of oligomeric state through allosteric pathways that mimic ligand binding. Science, 346, 2014
|
|