8A32

p53 cancer mutant Y220C in complex with iodophenol-based small-molecule stabilizer JC769

Summary for 8A32

• Entry DOI: 10.2210/pdb8a32/pdb
• Descriptor: Cellular tumor antigen p53, 4-[3,4-bis(fluoranyl)pyrrol-1-yl]-3,5-bis(iodanyl)-2-oxidanyl-benzoic acid, 1,2-ETHANEDIOL, ... (6 entities in total)
• Functional Keywords: tumor suppressor p53, cancer mutant, drug discovery, small-molecule stabilizer, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 50328.54

Authors

Balourdas, D.I.,Stephenson Clarke, J.R.,Baud, M.G.J.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC) (deposition date: 2022-06-06, release date: 2022-11-30, Last modification date: 2024-01-31)

• Primary citation: Stephenson Clarke, J.R.,Douglas, L.R.,Duriez, P.J.,Balourdas, D.I.,Joerger, A.C.,Khadiullina, R.,Bulatov, E.,Baud, M.G.J.; Discovery of Nanomolar-Affinity Pharmacological Chaperones Stabilizing the Oncogenic p53 Mutant Y220C.; Acs Pharmacol Transl Sci, 5:1169-1180, 2022; PubMed: 36407959; DOI: 10.1021/acsptsci.2c00164

Experimental method

X-RAY DIFFRACTION (1.47 Å)