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PDB: 155 件
6GUK
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CDK2 in complex with CGP74514A
分子名称: Cyclin-dependent kinase 2, ~{N}2-[(1~{R},2~{S})-2-azanylcyclohexyl]-~{N}6-(3-chlorophenyl)-9-ethyl-purine-2,6-diamine
著者Wood, D.J, Korolchuk, S, Tatum, N.J, Wang, L.Z, Endicott, J.A, Noble, M.E.M, Martin, M.P.
登録日2018-06-19
公開日2018-12-05
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.
Cell Chem Biol, 26, 2019
6G03
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NMR Solution Structure of yeast TSR2(1-152)
分子名称: Pre-rRNA-processing protein TSR2
著者Michel, E, Schuetz, S, Damberger, F.F, Allain, F.H.-T, Panse, V.G.
登録日2018-03-16
公開日2018-09-19
最終更新日2024-06-19
実験手法SOLUTION NMR
主引用文献Molecular basis for disassembly of an importin:ribosomal protein complex by the escortin Tsr2.
Nat Commun, 9, 2018
6Z1B
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Structure of K52-acetylated RutR in complex with uracil.
分子名称: 1,2-ETHANEDIOL, HTH-type transcriptional regulator RutR, URACIL
著者Kremer, M, Schulze, S, Lammers, M.
登録日2020-05-13
公開日2022-06-01
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structure of K52-acetylated RutR in complex with uracil.
To Be Published
6G04
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NMR Solution Structure of Yeast TSR2(1-152) in Complex with S26A(100-119)
分子名称: 40S ribosomal protein S26-A, Pre-rRNA-processing protein TSR2
著者Michel, E, Schuetz, S, Damberger, F.F, Allain, F.H.-T, Panse, V.G.
登録日2018-03-16
公開日2018-09-19
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Molecular basis for disassembly of an importin:ribosomal protein complex by the escortin Tsr2.
Nat Commun, 9, 2018
6GU6
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CDK1/Cks2 in complex with Dinaciclib
分子名称: 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium, Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2
著者Wood, D.J, Korolchuk, S, Tatum, N.J, Wang, L.Z, Endicott, J.A, Noble, M.E.M, Martin, M.P.
登録日2018-06-19
公開日2018-12-05
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.33 Å)
主引用文献Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.
Cell Chem Biol, 26, 2019
6GUH
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CDK2 in complex with AZD5438
分子名称: 1,2-ETHANEDIOL, 4-(2-methyl-3-propan-2-yl-imidazol-4-yl)-~{N}-(4-methylsulfonylphenyl)pyrimidin-2-amine, Cyclin-dependent kinase 2
著者Wood, D.J, Korolchuk, S, Tatum, N.J, Wang, L.Z, Endicott, J.A, Noble, M.E.M, Martin, M.P.
登録日2018-06-19
公開日2018-12-05
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.
Cell Chem Biol, 26, 2019
6GUC
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CDK2/CyclinA in complex with SU9516
分子名称: (3Z)-3-(1H-IMIDAZOL-5-YLMETHYLENE)-5-METHOXY-1H-INDOL-2(3H)-ONE, Cyclin-A2, Cyclin-dependent kinase 2
著者Wood, D.J, Korolchuk, S, Tatum, N.J, Wang, L.Z, Endicott, J.A, Noble, M.E.M, Martin, M.P.
登録日2018-06-19
公開日2018-12-05
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.
Cell Chem Biol, 26, 2019
6GUF
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CDK2/CyclinA in complex with CGP74514A
分子名称: Cyclin-A2, Cyclin-dependent kinase 2, N2-[(1R,2S)-2-AMINOCYCLOHEXYL]-N6-(3-CHLOROPHENYL)-9-ETHYL-9H-PURINE-2,6-DIAMINE
著者Wood, D.J, Korolchuk, S, Tatum, N.J, Wang, L.Z, Endicott, J.A, Noble, M.E.M, Martin, M.P.
登録日2018-06-19
公開日2018-12-05
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.
Cell Chem Biol, 26, 2019
6GUE
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CDK2/CyclinA in complex with AZD5438
分子名称: 4-(2-methyl-3-propan-2-yl-imidazol-4-yl)-~{N}-(4-methylsulfonylphenyl)pyrimidin-2-amine, Cyclin-A2, Cyclin-dependent kinase 2
著者Wood, D.J, Korolchuk, S, Tatum, N.J, Wang, L.Z, Endicott, J.A, Noble, M.E.M, Martin, M.P.
登録日2018-06-19
公開日2018-12-05
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.
Cell Chem Biol, 26, 2019
6GU7
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CDK1/Cks2 in complex with AZD5438
分子名称: 4-(2-methyl-3-propan-2-yl-imidazol-4-yl)-~{N}-(4-methylsulfonylphenyl)pyrimidin-2-amine, Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2
著者Wood, D.J, Korolchuk, S, Tatum, N.J, Wang, L.Z, Endicott, J.A, Noble, M.E.M, Martin, M.P.
登録日2018-06-19
公開日2018-12-05
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.
Cell Chem Biol, 26, 2019
5EI0
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BU of 5ei0 by Molmil
Structure of RCL-cleaved vaspin (serpinA12)
分子名称: Serpin A12
著者Pippel, J, Kuettner, B.E, Ulbricht, D, Daberger, J, Schultz, S, Heiker, J.T, Strater, N.
登録日2015-10-29
公開日2015-11-11
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of cleaved vaspin (serpinA12).
Biol.Chem., 397, 2016
6GU2
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CDK1/CyclinB/Cks2 in complex with Flavopiridol
分子名称: 2-(2-chlorophenyl)-8-[(3~{R},4~{R})-1-methyl-3-oxidanyl-piperidin-4-yl]-5,7-bis(oxidanyl)chromen-4-one, Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2, ...
著者Wood, D.J, Korolchuk, S, Tatum, N.J, Wang, L.Z, Endicott, J.A, Noble, M.E.M, Martin, M.P.
登録日2018-06-19
公開日2018-12-05
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.
Cell Chem Biol, 26, 2019
6GUB
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CDK2/CyclinA in complex with Flavopiridol
分子名称: 2-(2-chlorophenyl)-8-[(3~{R},4~{R})-1-methyl-3-oxidanyl-piperidin-4-yl]-5,7-bis(oxidanyl)chromen-4-one, Cyclin-A2, Cyclin-dependent kinase 2
著者Wood, D.J, Korolchuk, S, Tatum, N.J, Wang, L.Z, Endicott, J.A, Noble, M.E.M, Martin, M.P.
登録日2018-06-19
公開日2018-12-05
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.52 Å)
主引用文献Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.
Cell Chem Biol, 26, 2019
6GU3
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BU of 6gu3 by Molmil
CDK1/CyclinB/Cks2 in complex with AZD5438
分子名称: 4-(2-methyl-3-propan-2-yl-imidazol-4-yl)-~{N}-(4-methylsulfonylphenyl)pyrimidin-2-amine, Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2, ...
著者Wood, D.J, Korolchuk, S, Tatum, N.J, Wang, L.Z, Endicott, J.A, Noble, M.E.M, Martin, M.P.
登録日2018-06-19
公開日2018-12-05
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.
Cell Chem Biol, 26, 2019
3B97
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Crystal Structure of human Enolase 1
分子名称: Alpha-enolase, MAGNESIUM ION, SULFATE ION
著者Kang, H.J, Jung, S.K, Kim, S.J, Chung, S.J.
登録日2007-11-02
公開日2008-09-16
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of human alpha-enolase (hENO1), a multifunctional glycolytic enzyme.
Acta Crystallogr.,Sect.D, 64, 2008
6R9T
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Cryo-EM structure of autoinhibited human talin-1
分子名称: Talin-1
著者Dedden, D, Schumacher, S, Zacharias, M, Biertumpfel, C, Mizuno, N.
登録日2019-04-04
公開日2019-10-16
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (6.2 Å)
主引用文献The Architecture of Talin1 Reveals an Autoinhibition Mechanism.
Cell, 179, 2019
1K8G
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Crystal Structure of the N-terminal domain of Oxytricha nova telomere end binding protein alpha subunit both uncomplexed and complexed with telomeric ssDNA
分子名称: 5'-D(TP*TP*GP*GP*GP*G)-3', SULFATE ION, Telomere-Binding Protein alpha Subunit
著者Classen, S, Ruggles, J.A, Schultz, S.C.
登録日2001-10-24
公開日2001-12-20
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal structure of the N-terminal domain of Oxytricha nova telomere end-binding protein alpha subunit both uncomplexed and complexed with telomeric ssDNA.
J.Mol.Biol., 314, 2001
1KIX
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Dimeric Structure of the O. nova Telomere End Binding Protein Alpha Subunit with Bound ssDNA
分子名称: 5'-D(*T*TP*TP*TP*GP*GP*GP*G)-3', SULFATE ION, Telomere-Binding Protein alpha Subunit
著者Peersen, O.B, Ruggles, J.A, Schultz, S.C.
登録日2001-12-03
公開日2002-02-22
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Dimeric structure of the Oxytricha nova telomere end-binding protein alpha-subunit bound to ssDNA.
Nat.Struct.Biol., 9, 2002
3Q9U
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In silico and in vitro co-evolution of a high affinity complementary protein-protein interface
分子名称: COENZYME A, CoA binding protein, consensus ankyrin repeat
著者Karanicolas, J, Corn, J.E, Chen, I, Joachimiak, L.A, Dym, O, Chung, S, Albeck, S, Unger, T, Hu, W, Liu, G, Delbecq, S, Montelione, G.T, Spiegel, C, Liu, D, Baker, D, Israel Structural Proteomics Center (ISPC)
登録日2011-01-10
公開日2011-04-20
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A de novo protein binding pair by computational design and directed evolution.
Mol.Cell, 42, 2011
1WA9
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Crystal Structure of the PAS repeat region of the Drosophila clock protein PERIOD
分子名称: PERIOD CIRCADIAN PROTEIN
著者Yildiz, O, Doi, M, Yujnovsky, I, Cardone, L, Berndt, A, Hennig, S, Schulze, S, Urbanke, C, Sassone-Corsi, P, Wolf, E.
登録日2004-10-25
公開日2005-01-12
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Crystal Structure and Interactions of the Pas Repeat Region of the Drosophila Clock Protein Period
Mol.Cell, 17, 2005
3Q9N
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In silico and in vitro co-evolution of a high affinity complementary protein-protein interface
分子名称: CARBAMOYL SARCOSINE, COENZYME A, CoA binding protein, ...
著者Karanicolas, J, Corn, J.E, Chen, I, Joachimiak, L.A, Dym, O, Chung, S, Albeck, S, Unger, T, Hu, W, Liu, G, Delbecq, S, Montelione, G.T, Spiegel, C, Liu, D, Baker, D, Israel Structural Proteomics Center (ISPC)
登録日2011-01-09
公開日2011-04-27
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A de novo protein binding pair by computational design and directed evolution.
Mol.Cell, 42, 2011
4YC6
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CDK1/CKS1
分子名称: Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 1
著者Brown, N.R, Korolchuk, S, Martin, M.P, Stanley, W, Moukhametzianov, R, Noble, M.E.M, Endicott, J.A.
登録日2015-02-19
公開日2015-05-20
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.
Nat Commun, 6, 2015
1N39
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Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase
分子名称: CALCIUM ION, DNA complement strand, DNA inhibitor strand, ...
著者Norman, D.P, Chung, S.J, Verdine, G.L.
登録日2002-10-25
公開日2003-03-04
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase
Biochemistry, 42, 2003
1N3A
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Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase
分子名称: CALCIUM ION, DNA complement strand, DNA inhibitor strand, ...
著者Norman, D.P, Chung, S.J, Verdine, G.L.
登録日2002-10-25
公開日2003-03-04
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase
Biochemistry, 42, 2003
1N3C
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Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase
分子名称: 8-oxoG-containing DNA, CALCIUM ION, DNA complement strand, ...
著者Norman, D.P, Chung, S.J, Verdine, G.L.
登録日2002-10-25
公開日2003-03-04
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase
Biochemistry, 42, 2003

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