6GUH

CDK2 in complex with AZD5438

Summary for 6GUH

Entry DOI	10.2210/pdb6guh/pdb
Descriptor	Cyclin-dependent kinase 2, 4-(2-methyl-3-propan-2-yl-imidazol-4-yl)-~{N}-(4-methylsulfonylphenyl)pyrimidin-2-amine, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	cdk2, inhibitor, cell cycle
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	35256.94
Authors	Wood, D.J.,Korolchuk, S.,Tatum, N.J.,Wang, L.Z.,Endicott, J.A.,Noble, M.E.M.,Martin, M.P. (deposition date: 2018-06-19, release date: 2018-12-05, Last modification date: 2024-01-17)
Primary citation	Wood, D.J.,Korolchuk, S.,Tatum, N.J.,Wang, L.Z.,Endicott, J.A.,Noble, M.E.M.,Martin, M.P. Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition. Cell Chem Biol, 26:121-130.e5, 2019 Cited by PubMed: 30472117 DOI: 10.1016/j.chembiol.2018.10.015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation