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PDB: 982 件
3F9V
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Crystal Structure Of A Near Full-Length Archaeal MCM: Functional Insights For An AAA+ Hexameric Helicase
分子名称: Minichromosome maintenance protein MCM
著者Chen, X.J, Brewster, A.S, Wang, G.G, Yu, X, Greenleaf, W, Tjajadi, M, Klein, M.
登録日2008-11-14
公開日2008-12-30
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (4.35 Å)
主引用文献Crystal structure of a near-full-length archaeal MCM: Functional insights for an AAA+ hexameric helicase.
Proc.Natl.Acad.Sci.USA, 105, 2008
6OEQ
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BU of 6oeq by Molmil
Cryo-EM structure of mouse RAG1/2 12RSS-PRC/23RSS-NFC complex (DNA1)
分子名称: CALCIUM ION, DNA (46-MER), DNA (57-MER), ...
著者Chen, X, Cui, Y, Zhou, Z.H, Yang, W, Gellert, M.
登録日2019-03-27
公開日2020-01-29
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献Cutting antiparallel DNA strands in a single active site.
Nat.Struct.Mol.Biol., 27, 2020
6OES
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BU of 6oes by Molmil
Cryo-EM structure of mouse RAG1/2 STC complex (without NBD domain)
分子名称: CALCIUM ION, DNA (34-MER), DNA (35-MER), ...
著者Chen, X, Cui, Y, Zhou, Z.H, Yang, W, Gellert, M.
登録日2019-03-27
公開日2020-01-22
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.06 Å)
主引用文献How mouse RAG recombinase avoids DNA transposition.
Nat.Struct.Mol.Biol., 27, 2020
6OEN
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BU of 6oen by Molmil
Cryo-EM structure of mouse RAG1/2 PRC complex (DNA1)
分子名称: CALCIUM ION, DNA (46-MER), DNA (57-MER), ...
著者Chen, X, Cui, Y, Zhou, Z.H, Yang, W, Gellert, M.
登録日2019-03-27
公開日2020-01-29
最終更新日2020-02-26
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献Cutting antiparallel DNA strands in a single active site.
Nat.Struct.Mol.Biol., 27, 2020
6OEO
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BU of 6oeo by Molmil
Cryo-EM structure of mouse RAG1/2 NFC complex (DNA1)
分子名称: CALCIUM ION, DNA (46-MER), DNA (57-MER), ...
著者Chen, X, Cui, Y, Zhou, Z.H, Yang, W, Gellert, M.
登録日2019-03-27
公開日2020-01-29
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.69 Å)
主引用文献Cutting antiparallel DNA strands in a single active site.
Nat.Struct.Mol.Biol., 27, 2020
6OEP
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BU of 6oep by Molmil
Cryo-EM structure of mouse RAG1/2 12RSS-NFC/23RSS-PRC complex (DNA1)
分子名称: CALCIUM ION, DNA (46-MER), DNA (57-MER), ...
著者Chen, X, Cui, Y, Zhou, Z.H, Yang, W, Gellert, M.
登録日2019-03-27
公開日2020-01-29
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Cutting antiparallel DNA strands in a single active site.
Nat.Struct.Mol.Biol., 27, 2020
6OET
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BU of 6oet by Molmil
Cryo-EM structure of mouse RAG1/2 STC complex
分子名称: CALCIUM ION, DNA (30-MER), DNA (39-MER), ...
著者Chen, X, Cui, Y, Zhou, Z.H, Yang, W, Gellert, M.
登録日2019-03-27
公開日2020-01-22
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献How mouse RAG recombinase avoids DNA transposition.
Nat.Struct.Mol.Biol., 27, 2020
6OEM
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BU of 6oem by Molmil
Cryo-EM structure of mouse RAG1/2 PRC complex (DNA0)
分子名称: DNA (46-MER), DNA (57-MER), High mobility group protein B1, ...
著者Chen, X, Cui, Y, Zhou, Z.H, Yang, W, Gellert, M.
登録日2019-03-27
公開日2020-01-29
最終更新日2020-02-26
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Cutting antiparallel DNA strands in a single active site.
Nat.Struct.Mol.Biol., 27, 2020
6OER
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BU of 6oer by Molmil
Cryo-EM structure of mouse RAG1/2 NFC complex (DNA2)
分子名称: CALCIUM ION, DNA (46-MER), DNA (57-MER), ...
著者Chen, X, Cui, Y, Zhou, Z.H, Yang, W, Gellert, M.
登録日2019-03-27
公開日2020-01-29
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.29 Å)
主引用文献Cutting antiparallel DNA strands in a single active site.
Nat.Struct.Mol.Biol., 27, 2020
8GXS
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BU of 8gxs by Molmil
PIC-Mediator in complex with +1 nucleosome (T40N) in H-binding state
分子名称: CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ...
著者Chen, X, Wang, X, Liu, W, Ren, Y, Qu, X, Li, J, Yin, X.
登録日2022-09-21
公開日2022-11-02
実験手法ELECTRON MICROSCOPY (4.16 Å)
主引用文献Structures of +1 nucleosome-bound PIC-Mediator complex.
Science, 378, 2022
8GXQ
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PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state
分子名称: CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ...
著者Chen, X, Wang, X, Liu, W, Ren, Y, Qu, X, Li, J, Yin, X, Xu, Y.
登録日2022-09-21
公開日2022-11-02
実験手法ELECTRON MICROSCOPY (5.04 Å)
主引用文献Structures of +1 nucleosome-bound PIC-Mediator complex.
Science, 378, 2022
8KFD
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BU of 8kfd by Molmil
Ferritin drug carrier(FDC) for encapsulated platinum (IV) prodrug for esophageal squamous cell carcinoma targeted therapy
分子名称: CALCIUM ION, CHLORIDE ION, Ferritin heavy chain, ...
著者Chen, X.
登録日2023-08-15
公開日2024-05-29
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Ferritin drug carrier(FDC) for encapsulated platinum (IV) prodrug for esophageal squamous cell carcinoma targeted therapy
To Be Published
7DTZ
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BU of 7dtz by Molmil
FGFR4 complex with a covalent inhibitor
分子名称: Fibroblast growth factor receptor 4, N-[2-[[5-[[2,6-bis(chloranyl)-3,5-dimethoxy-phenyl]methoxy]pyrimidin-2-yl]amino]-3-methyl-phenyl]-2-fluoranyl-prop-2-enamide, SULFATE ION
著者Chen, X.J, Dai, S.Y, Chen, Y.H.
登録日2021-01-07
公開日2021-04-14
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Investigation of Covalent Warheads in the Design of 2-Aminopyrimidine-based FGFR4 Inhibitors.
Acs Med.Chem.Lett., 12, 2021
7WCT
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BU of 7wct by Molmil
Crystal structure of FGFR4 kinase domain with 7v
分子名称: Fibroblast growth factor receptor 4, GLYCEROL, SULFATE ION, ...
著者Chen, X.J, Lin, Q.M, Dai, S.Y, Chen, Y.H.
登録日2021-12-20
公開日2022-03-30
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.106 Å)
主引用文献Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4.
J.Med.Chem., 65, 2022
7WCW
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BU of 7wcw by Molmil
Crystal structure of FGFR4(V550L) kinase domain with 7v
分子名称: Fibroblast growth factor receptor 4, SULFATE ION, ~{N}-[2-[[5-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1~{H}-indazol-3-yl]amino]-3-fluoranyl-5-(4-morpholin-4-ylpiperidin-1-yl)phenyl]propanamide
著者Chen, X.J, Lin, Q.M, Dai, S.Y, Chen, Y.H.
登録日2021-12-20
公開日2022-03-30
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.317 Å)
主引用文献Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4.
J.Med.Chem., 65, 2022
7WCX
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BU of 7wcx by Molmil
Crystal structure of FGFR4(V550M) kinase domain with 7v
分子名称: Fibroblast growth factor receptor 4, SULFATE ION, ~{N}-[2-[[5-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1~{H}-indazol-3-yl]amino]-3-fluoranyl-5-(4-morpholin-4-ylpiperidin-1-yl)phenyl]propanamide
著者Chen, X.J, Lin, Q.M, Dai, S.Y, Chen, Y.H.
登録日2021-12-20
公開日2022-03-30
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.175 Å)
主引用文献Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4.
J.Med.Chem., 65, 2022
7YBO
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BU of 7ybo by Molmil
Crystal structure of FGFR4 kinase domain with 10z
分子名称: Fibroblast growth factor receptor 4, SULFATE ION, ~{N}-[4-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-5-cyano-pyridin-2-yl]-6-bromanyl-5-(hydroxymethyl)-1-(2-morpholin-4-ylethyl)pyrrolo[3,2-b]pyridine-3-carboxamide
著者Chen, X.J, Lin, Q.M, Chen, Y.H.
登録日2022-06-29
公開日2022-11-16
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.307 Å)
主引用文献Design, Synthesis, and Biological Evaluation of 5-Formyl-pyrrolo[3,2- b ]pyridine-3-carboxamides as New Selective, Potent, and Reversible-Covalent FGFR4 Inhibitors.
J.Med.Chem., 65, 2022
7YC3
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BU of 7yc3 by Molmil
Crystal structure of FGFR4 kinase domain with 10t
分子名称: 6-bromanyl-~{N}-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-5-methanoyl-1-(2-morpholin-4-ylethyl)pyrrolo[3,2-b]pyridine-3-carboxamide, Fibroblast growth factor receptor 4, GLYCEROL, ...
著者Chen, X.J, Lin, Q.M, Chen, Y.H.
登録日2022-06-30
公開日2022-11-16
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.987 Å)
主引用文献Design, Synthesis, and Biological Evaluation of 5-Formyl-pyrrolo[3,2- b ]pyridine-3-carboxamides as New Selective, Potent, and Reversible-Covalent FGFR4 Inhibitors.
J.Med.Chem., 65, 2022
7YC1
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BU of 7yc1 by Molmil
Crystal structure of FGFR4 kinase domain with 10d
分子名称: Fibroblast growth factor receptor 4, GLYCEROL, SULFATE ION, ...
著者Chen, X.J, Lin, Q.M, Chen, Y.H.
登録日2022-06-30
公開日2022-11-16
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.535 Å)
主引用文献Design, Synthesis, and Biological Evaluation of 5-Formyl-pyrrolo[3,2- b ]pyridine-3-carboxamides as New Selective, Potent, and Reversible-Covalent FGFR4 Inhibitors.
J.Med.Chem., 65, 2022
7YBP
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BU of 7ybp by Molmil
Crystal structure of FGFR4(V550L) kinase domain with 10z
分子名称: Fibroblast growth factor receptor 4, SULFATE ION, ~{N}-[4-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-5-cyano-pyridin-2-yl]-6-bromanyl-5-(hydroxymethyl)-1-(2-morpholin-4-ylethyl)pyrrolo[3,2-b]pyridine-3-carboxamide
著者Chen, X.J, Lin, Q.M, Chen, Y.H.
登録日2022-06-29
公開日2022-11-16
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.243 Å)
主引用文献Design, Synthesis, and Biological Evaluation of 5-Formyl-pyrrolo[3,2- b ]pyridine-3-carboxamides as New Selective, Potent, and Reversible-Covalent FGFR4 Inhibitors.
J.Med.Chem., 65, 2022
7YBX
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BU of 7ybx by Molmil
Crystal structure of FGFR4(V550M) kinase domain with 10z
分子名称: Fibroblast growth factor receptor 4, SULFATE ION, ~{N}-[4-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-5-cyano-pyridin-2-yl]-6-bromanyl-5-(hydroxymethyl)-1-(2-morpholin-4-ylethyl)pyrrolo[3,2-b]pyridine-3-carboxamide
著者Chen, X.J, Lin, Q.M, Chen, Y.H.
登録日2022-06-30
公開日2022-11-16
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.233 Å)
主引用文献Design, Synthesis, and Biological Evaluation of 5-Formyl-pyrrolo[3,2- b ]pyridine-3-carboxamides as New Selective, Potent, and Reversible-Covalent FGFR4 Inhibitors.
J.Med.Chem., 65, 2022
7F8L
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BU of 7f8l by Molmil
Crystal structure of Bat coronavirus RaTG13 ORF8 accessory protein
分子名称: CALCIUM ION, Nonstructural protein NS8
著者Chen, X, Zhou, Z, Chen, S.
登録日2021-07-02
公開日2022-01-19
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.762 Å)
主引用文献Crystal Structures of Bat and Human Coronavirus ORF8 Protein Ig-Like Domain Provide Insights Into the Diversity of Immune Responses.
Front Immunol, 12, 2021
8J9L
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BU of 8j9l by Molmil
Crystal Structure of Human H-Ferritin variant 123F assembling in solution2
分子名称: FE (III) ION, Ferritin heavy chain
著者Chen, X, Zhao, G.
登録日2023-05-04
公開日2024-01-31
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Shape-Anisotropic Assembly of Protein Nanocages with Identical Building Blocks by Designed Intermolecular pi-pi Interactions.
Adv Sci, 10, 2023
8GI6
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BU of 8gi6 by Molmil
Crystal structure of RhoA mutant L69R complexed with GDP
分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Transforming protein RhoA
著者Chen, X, Qian, X, Chandravanshi, M, Lowy, D.R, Walters, K.J.
登録日2023-03-13
公開日2024-03-20
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Ras-like GTPases mutant structures
To be published
8GI3
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BU of 8gi3 by Molmil
Crystal structure of RhoA mutant L69P complexed with GDP
分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Transforming protein RhoA
著者Chen, X, Qian, X, Chandravanshi, M, Lowy, D.R, Walters, K.J.
登録日2023-03-13
公開日2024-03-20
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献Ras-like GTPases mutants structure
To be published

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件を2024-07-24に公開中

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