6KCW
 
 | | Structure of alginate lyase Aly36B | | 分子名称: | Alginate lyase, CALCIUM ION, PHOSPHATE ION | | 著者 | Dong, F, Chen, X.L, Zhang, Y.Z. | | 登録日 | 2019-06-29 | | 公開日 | 2020-06-24 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | Alginate Lyase Aly36B is a New Bacterial Member of the Polysaccharide Lyase Family 36 and Catalyzes by a Novel Mechanism With Lysine as Both the Catalytic Base and Catalytic Acid.
J.Mol.Biol., 431, 2019
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6KCV
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6KZK
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4E2I
 | | The Complex Structure of the SV40 Helicase Large T Antigen and p68 Subunit of DNA Polymerase Alpha-Primase | | 分子名称: | DNA polymerase alpha subunit B, Large T antigen, ZINC ION | | 著者 | Zhou, B, Arnett, D.R, Yu, X, Brewster, A, Sowd, G.A, Xie, C.L, Vila, S, Gai, D, Fanning, E, Chen, X.S. | | 登録日 | 2012-03-08 | | 公開日 | 2012-06-13 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (5 Å) | | 主引用文献 | Structural basis for the interaction of a hexameric replicative helicase with the regulatory subunit of human DNA polymerase alpha-primase.
J.Biol.Chem., 287, 2012
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4EXN
 | | Crystal structure of mouse Interleukin-34 | | 分子名称: | Interleukin-34, alpha-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Liu, H, Leo, C, Chen, X, Wong, B.R, Williams, L.T, Lin, H, He, X. | | 登録日 | 2012-04-30 | | 公開日 | 2012-05-30 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | The mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1.
Biochim.Biophys.Acta, 1824, 2012
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7C8G
 | | Structure of alginate lyase AlyC3 | | 分子名称: | Alginate lyase AlyC3, GLYCEROL, SUCCINIC ACID | | 著者 | Zhang, Y.Z, Xu, F, Chen, X.L, Wang, P. | | 登録日 | 2020-05-30 | | 公開日 | 2020-10-07 | | 最終更新日 | 2020-12-16 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural and molecular basis for the substrate positioning mechanism of a new PL7 subfamily alginate lyase from the arctic.
J.Biol.Chem., 295, 2020
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7XRJ
 | | crystal structure of N-acetyltransferase DgcN-25328 | | 分子名称: | Putative NAD-dependent epimerase/dehydratase family protein, SULFATE ION | | 著者 | Zhang, Y.Z, Yu, Y, Cao, H.Y, Chen, X.L, Wang, P. | | 登録日 | 2022-05-10 | | 公開日 | 2023-02-01 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Novel D-glutamate catabolic pathway in marine Proteobacteria and halophilic archaea.
Isme J, 17, 2023
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5ZE2
 | | Hairpin Complex, RAG1/2-hairpin 12RSS/23RSS complex in 5mM Mn2+ for 2 min at 4'C | | 分子名称: | 1,2-ETHANEDIOL, DNA (30-MER), DNA (31-MER), ... | | 著者 | Kim, M.S, Chuenchor, W, Chen, X, Gellert, M, Yang, W. | | 登録日 | 2018-02-25 | | 公開日 | 2018-04-25 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Cracking the DNA Code for V(D)J Recombination
Mol. Cell, 70, 2018
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5ZDZ
 | | Hairpin Forming Complex, RAG1/2-Nicked 12RSS/23RSS complex in Ca2+ | | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, DNA (30-MER), ... | | 著者 | Kim, M.S, Chuenchor, W, Chen, X, Gellert, M, Yang, W. | | 登録日 | 2018-02-25 | | 公開日 | 2018-04-25 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Cracking the DNA Code for V(D)J Recombination
Mol. Cell, 70, 2018
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5ZE0
 | | Hairpin Forming Complex, RAG1/2-Nicked(with Dideoxy) 12RSS/23RSS complex in Mg2+ | | 分子名称: | 1,2-ETHANEDIOL, DNA (30-MER), DNA (39-MER), ... | | 著者 | Kim, M.S, Chuenchor, W, Chen, X, Gellert, M, Yang, W. | | 登録日 | 2018-02-25 | | 公開日 | 2018-04-25 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Cracking the DNA Code for V(D)J Recombination
Mol. Cell, 70, 2018
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5ZE1
 | | Hairpin Forming Complex, RAG1/2-Nicked 12RSS/23RSS complex in 2mM Mn2+ for 10 min at 4'C | | 分子名称: | 1,2-ETHANEDIOL, DNA, HMGB1 A-B box, ... | | 著者 | Kim, M.S, Chuenchor, W, Chen, X, Gellert, M, Yang, W. | | 登録日 | 2018-02-25 | | 公開日 | 2018-04-25 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Cracking the DNA Code for V(D)J Recombination
Mol. Cell, 70, 2018
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4GDF
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6PBD
 | | DNA N6-Adenine Methyltransferase CcrM In Complex with Double-Stranded DNA Oligonucleotide Containing Its Recognition Sequence GAATC | | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*CP*GP*AP*TP*TP*CP*AP*AP*TP*GP*AP*AP*TP*CP*CP*CP*AP*AP*G)-3'), DNA (5'-D(*GP*CP*TP*TP*GP*GP*GP*AP*TP*TP*CP*AP*TP*TP*GP*AP*AP*TP*C)-3'), ... | | 著者 | Horton, J.R, Cheng, X, Woodcock, C.B. | | 登録日 | 2019-06-13 | | 公開日 | 2019-10-23 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.343 Å) | | 主引用文献 | The cell cycle-regulated DNA adenine methyltransferase CcrM opens a bubble at its DNA recognition site.
Nat Commun, 10, 2019
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4FDG
 | | Crystal Structure of an Archaeal MCM Filament | | 分子名称: | Minichromosome maintenance protein MCM, ZINC ION | | 著者 | Slaymaker, I.M, Fu, Y, Brewster, A.B, Chen, X.S. | | 登録日 | 2012-05-28 | | 公開日 | 2013-03-06 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (4.1 Å) | | 主引用文献 | Mini-chromosome maintenance complexes form a filament to remodel DNA structure and topology.
Nucleic Acids Res., 41, 2013
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7YGI
 | | Crystal structure of p53 DBD domain in complex with azurin | | 分子名称: | Azurin, Cellular tumor antigen p53, PHOSPHATE ION, ... | | 著者 | Jiang, W.X, Zuo, J.Q, Hu, J.J, Chen, X.Q, Ma, L.X, Liu, Z, Xing, Q. | | 登録日 | 2022-07-11 | | 公開日 | 2023-02-08 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural basis of bacterial effector protein azurin targeting tumor suppressor p53 and inhibiting its ubiquitination.
Commun Biol, 6, 2023
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4IAN
 | | Crystal Structure of apo Human PRPF4B kinase domain | | 分子名称: | SULFATE ION, Serine/threonine-protein kinase PRP4 homolog | | 著者 | Mechin, I, Haas, K, Chen, X, Zhang, Y, McLean, L. | | 登録日 | 2012-12-06 | | 公開日 | 2013-08-28 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | | 主引用文献 | Evaluation of Cancer Dependence and Druggability of PRP4 Kinase Using Cellular, Biochemical, and Structural Approaches.
J.Biol.Chem., 288, 2013
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7WG3
 | | Structural basis of interleukin-17B receptor in complex with a neutralizing antibody D9 for guiding humanization and affinity maturation for cancer therapy | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of D9 Fab, IL17RB protein, ... | | 著者 | Lee, W.H, Chen, X.R, Liu, I.J, Lee, J.H, Hu, C.M, Wu, H.C, Wang, S.K, Lee, W.H, Ma, C. | | 登録日 | 2021-12-28 | | 公開日 | 2022-11-09 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | Structural basis of interleukin-17B receptor in complex with a neutralizing antibody for guiding humanization and affinity maturation.
Cell Rep, 41, 2022
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5V3J
 | | mouseZFP568-ZnF1-10 in complex with DNA | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DNA (26-MER), MAGNESIUM ION, ... | | 著者 | Patel, A, Cheng, X. | | 登録日 | 2017-03-07 | | 公開日 | 2018-03-07 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.064 Å) | | 主引用文献 | DNA Conformation Induces Adaptable Binding by Tandem Zinc Finger Proteins.
Cell, 173, 2018
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5UND
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5ZHY
 | | Structural characterization of the HCoV-229E fusion core | | 分子名称: | Spike glycoprotein | | 著者 | Zhang, W, Zheng, Q, Yan, M, Chen, X, Yang, H, Zhou, W, Rao, Z. | | 登録日 | 2018-03-13 | | 公開日 | 2018-06-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.441 Å) | | 主引用文献 | Structural characterization of the HCoV-229E fusion core.
Biochem. Biophys. Res. Commun., 497, 2018
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7E6T
 | | Structural insights into the activation of human calcium-sensing receptor | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CYCLOMETHYLTRYPTOPHAN, ... | | 著者 | Geng, Y, Chen, X.C, Wang, L, Cui, Q.Q, Ding, Z.Y, Han, L, Kou, Y.J, Zhang, W.Q, Wang, H.N, Jia, X.M, Dai, M, Shi, Z.Z, Li, Y.Y, Li, X.Y. | | 登録日 | 2021-02-24 | | 公開日 | 2021-09-22 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural insights into the activation of human calcium-sensing receptor.
Elife, 10, 2021
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7E6U
 | | the complex of inactive CaSR and NB2D11 | | 分子名称: | Extracellular calcium-sensing receptor, NB-2D11 | | 著者 | Geng, Y, Chen, X.C, Wang, L, Cui, Q.Q, Ding, Z.Y, Han, L, Kou, Y.J, Zhang, W.Q, Wang, H.N, Jia, X.M, Dai, M, Shi, Z.Z, Li, Y.Y, Li, X.Y. | | 登録日 | 2021-02-24 | | 公開日 | 2021-09-22 | | 実験手法 | ELECTRON MICROSCOPY (6 Å) | | 主引用文献 | Structural insights into the activation of human calcium-sensing receptor.
Elife, 10, 2021
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6BVH
 | | Trypsin complexed with a modified sunflower trypsin inhibitor, SFTI-TCTR(N12,N14) | | 分子名称: | CALCIUM ION, Cationic trypsin, GLYCEROL, ... | | 著者 | Riley, B.T, Chen, X. | | 登録日 | 2017-12-13 | | 公開日 | 2018-12-19 | | 最終更新日 | 2019-01-30 | | 実験手法 | X-RAY DIFFRACTION (1.927 Å) | | 主引用文献 | Potent, multi-target serine protease inhibition achieved by a simplified beta-sheet motif.
PLoS ONE, 14, 2019
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5V3M
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7YHN
 | | ANTI-TUMOR AGENT Y48 IN COMPLEX WITH TUBULIN | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-methyl-3-[(4-methylphenyl)sulfonylamino]-~{N}-[(6-methylpyridin-3-yl)methyl]benzamide, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Du, T, Ji, M, Hou, Z, Lin, S, Zhang, J, Wu, D, Zhang, K, Lu, D, Xu, H, Chen, X. | | 登録日 | 2022-07-14 | | 公開日 | 2023-07-26 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Optimization of Benzamide Derivatives as Potent and Orally Active Tubulin Inhibitors Targeting the Colchicine Binding Site.
J.Med.Chem., 65, 2022
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