4E2I
The Complex Structure of the SV40 Helicase Large T Antigen and p68 Subunit of DNA Polymerase Alpha-Primase
Summary for 4E2I
Entry DOI | 10.2210/pdb4e2i/pdb |
Descriptor | Large T antigen, DNA polymerase alpha subunit B, ZINC ION (3 entities in total) |
Functional Keywords | replication initiation, hydrolase-dna binding complex, hydrolase-dna binding protein complex, hydrolase/dna binding protein |
Biological source | Simian virus 40 (SV40) More |
Cellular location | Nucleus: Q14181 |
Total number of polymer chains | 23 |
Total formula weight | 598246.55 |
Authors | Zhou, B.,Arnett, D.R.,Yu, X.,Brewster, A.,Sowd, G.A.,Xie, C.L.,Vila, S.,Gai, D.,Fanning, E.,Chen, X.S. (deposition date: 2012-03-08, release date: 2012-06-13, Last modification date: 2024-02-28) |
Primary citation | Zhou, B.,Arnett, D.R.,Yu, X.,Brewster, A.,Sowd, G.A.,Xie, C.L.,Vila, S.,Gai, D.,Fanning, E.,Chen, X.S. Structural basis for the interaction of a hexameric replicative helicase with the regulatory subunit of human DNA polymerase alpha-primase. J.Biol.Chem., 287:26854-26866, 2012 Cited by PubMed: 22700977DOI: 10.1074/jbc.M112.363655 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (5 Å) |
Structure validation
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