2PV9
 
 | | Crystal structure of murine thrombin in complex with the extracellular fragment of murine PAR4 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Proteinase-activated receptor 4, Thrombin heavy chain, ... | | 著者 | Bah, A, Chen, Z, Bush-Pelc, L.A, Mathews, F.S, Di Cera, E. | | 登録日 | 2007-05-09 | | 公開日 | 2007-07-10 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4.
Proc.Natl.Acad.Sci.Usa, 104, 2007
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7Q5W
 | | The tandem SH2 domains of SYK with a bound TYROBP diphospho-ITAM peptide | | 分子名称: | 1,2-ETHANEDIOL, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Bradshaw, W.J, Katis, V.L, Chen, Z, Bountra, C, von Delft, F, Gileadi, O, Brennan, P.E. | | 登録日 | 2021-11-04 | | 公開日 | 2021-11-24 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The tandem SH2 domains of SYK
To Be Published
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2PUX
 | | Crystal structure of murine thrombin in complex with the extracellular fragment of murine PAR3 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Proteinase-activated receptor 3, Thrombin heavy chain, ... | | 著者 | Bah, A, Chen, Z, Bush-Pelc, L.A, Mathews, F.S, Di Cera, E. | | 登録日 | 2007-05-09 | | 公開日 | 2007-07-10 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4.
Proc.Natl.Acad.Sci.Usa, 104, 2007
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7QZQ
 | | Crystal structure of the kelch domain of human KBTBD12 | | 分子名称: | 1,2-ETHANEDIOL, Kelch repeat and BTB domain-containing protein 12, SODIUM ION | | 著者 | Manning, C.E, Chen, Z, Chen, X, Bradshaw, W.J, Bakshi, S, Mckinley, G, Chalk, R, Burgess-Brown, N, von Delft, F, Bullock, A.N. | | 登録日 | 2022-01-31 | | 公開日 | 2022-05-04 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | | 主引用文献 | Crystal structure of the kelch domain of human KBTBD12
To Be Published
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2X87
 | | Crystal Structure of the reconstituted CotA | | 分子名称: | 1,2-ETHANEDIOL, COPPER (II) ION, HYDROXIDE ION, ... | | 著者 | Bento, I, Silva, C.S, Chen, Z, Martins, L.O, Lindley, P.F, Soares, C.M. | | 登録日 | 2010-03-06 | | 公開日 | 2010-09-22 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Mechanisms Underlying Dioxygen Reduction in Laccases. Structural and Modelling Studies Focusing on Proton Transfer.
Bmc Struct.Biol., 10, 2010
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2X88
 | | Crystal Structure of HoloCotA | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, COPPER (II) ION, OXYGEN MOLECULE, ... | | 著者 | Bento, I, Silva, C.S, Chen, Z, Martins, L.O, Lindley, P.F, Soares, C.M. | | 登録日 | 2010-03-06 | | 公開日 | 2010-09-22 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Mechanisms Underlying Dioxygen Reduction in Laccases. Structural and Modelling Studies Focusing on Proton Transfer.
Bmc Struct.Biol., 10, 2010
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2WSD
 | | Proximal mutations at the type 1 Cu site of CotA-laccase: I494A mutant | | 分子名称: | 1,2-ETHANEDIOL, COPPER (II) ION, OXYGEN MOLECULE, ... | | 著者 | Silva, C.S, Durao, P, Chen, Z, Soares, C.M, Pereira, M.M, Todorovic, S, Hildebrandt, P, Martins, L.O, Lindley, P.F, Bento, I. | | 登録日 | 2009-09-04 | | 公開日 | 2010-09-29 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Proximal Mutations at the Type 1 Copper Site of Cota Laccase: Spectroscopic, Redox, Kinetic and Structural Characterization of I494A and L386A Mutants.
Biochem.J., 412, 2008
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7BWT
 | | SopD-Rab8 complex structure | | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Jiang, K, Tong, M, Chen, Z, Gao, X. | | 登録日 | 2020-04-16 | | 公開日 | 2021-02-24 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The Salmonella effector protein SopD targets Rab8 to positively and negatively modulate the inflammatory response.
Nat Microbiol, 6, 2021
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1T3Y
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1T3X
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5D0N
 | | Crystal structure of maize PDRP bound with AMP | | 分子名称: | ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, Pyruvate, ... | | 著者 | Jiang, L, Chen, Z. | | 登録日 | 2015-08-03 | | 公開日 | 2016-02-24 | | 最終更新日 | 2016-03-09 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural Basis of Reversible Phosphorylation by Maize Pyruvate Orthophosphate Dikinase Regulatory Protein
Plant Physiol., 170, 2016
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5D1F
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1TQF
 | | Crystal structure of human Beta secretase complexed with inhibitor | | 分子名称: | 3-{2-[(5-AMINOPENTYL)AMINO]-2-OXOETHOXY}-5-({[1-(4-FLUOROPHENYL)ETHYL]AMINO}CARBONYL)PHENYL PHENYLMETHANESULFONATE, Beta-secretase 1 | | 著者 | Munshi, S, Chen, Z, Kuo, L. | | 登録日 | 2004-06-17 | | 公開日 | 2004-11-09 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Identification of a small molecule nonpeptide active site beta-secretase inhibitor that displays a nontraditional binding mode for aspartyl proteases.
J.Med.Chem., 47, 2004
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3BV9
 | | Structure of Thrombin Bound to the Inhibitor FM19 | | 分子名称: | FM19 inhibitor, GLYCEROL, IODIDE ION, ... | | 著者 | Nieman, M.T, Burke, F, Warnock, M, Zhou, Y, Sweigert, J, Chen, A, Ricketts, D, Lucchesi, B.R, Chen, Z, Di Cera, E, Hilfinger, J, Mosberg, H.I, Schmaier, A.H. | | 登録日 | 2008-01-05 | | 公開日 | 2008-03-04 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Thrombostatin FM compounds: direct thrombin inhibitors - mechanism of action in vitro and in vivo.
J.Thromb.Haemost., 6, 2008
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7THM
 | | SARS-CoV-2 nsp12/7/8 complex with a native N-terminus nsp9 | | 分子名称: | MANGANESE (II) ION, Non-structural protein 7, Non-structural protein 8, ... | | 著者 | Osinski, A, Tagliabracci, V.S, Chen, Z, Li, Y. | | 登録日 | 2022-01-11 | | 公開日 | 2022-03-16 | | 最終更新日 | 2024-01-17 | | 実験手法 | ELECTRON MICROSCOPY (3.18 Å) | | 主引用文献 | The mechanism of RNA capping by SARS-CoV-2.
Nature, 609, 2022
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1GG4
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6A59
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2PKA
 | | REFINED 2 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF PORCINE PANCREATIC KALLIKREIN A, A SPECIFIC TRYPSIN-LIKE SERINE PROTEINASE. CRYSTALLIZATION, STRUCTURE DETERMINATION, CRYSTALLOGRAPHIC REFINEMENT, STRUCTURE AND ITS COMPARISON WITH BOVINE TRYPSIN | | 分子名称: | BENZAMIDINE, KALLIKREIN A | | 著者 | Bode, W, Chen, Z. | | 登録日 | 1984-05-21 | | 公開日 | 1984-07-19 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Refined 2 A X-ray crystal structure of porcine pancreatic kallikrein A, a specific trypsin-like serine proteinase. Crystallization, structure determination, crystallographic refinement, structure and its comparison with bovine trypsin.
J.Mol.Biol., 164, 1983
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4FWJ
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2PGQ
 | | Human thrombin mutant C191A-C220A in complex with the inhibitor PPACK | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, Thrombin heavy chain, ... | | 著者 | Bush-Pelc, L.A, Marino, F, Chen, Z, Pineda, A.O, Mathews, F.S, Di Cera, E. | | 登録日 | 2007-04-10 | | 公開日 | 2007-07-17 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Important role of the cys-191 cys-220 disulfide bond in thrombin function and allostery
J.Biol.Chem., 282, 2007
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2PGB
 | | Inhibitor-free human thrombin mutant C191A-C220A | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Prothrombin, SULFATE ION | | 著者 | Bush-Pelc, L.A, Marino, F, Chen, Z, Pineda, A.O, Mathews, F.S, Di Cera, E. | | 登録日 | 2007-04-09 | | 公開日 | 2007-07-17 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | | 主引用文献 | Important role of the cys-191 cys-220 disulfide bond in thrombin function and allostery
J.Biol.Chem., 282, 2007
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3KLX
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3KL1
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4XXB
 | | Crystal structure of human MDM2-RPL11 | | 分子名称: | 60S ribosomal protein L11, BETA-MERCAPTOETHANOL, E3 ubiquitin-protein ligase Mdm2, ... | | 著者 | Zheng, J, Chen, Z. | | 登録日 | 2015-01-30 | | 公開日 | 2015-08-12 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation
Genes Dev., 29, 2015
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1INP
 | | CRYSTAL STRUCTURE OF INOSITOL POLYPHOSPHATE 1-PHOSPHATASE AT 2.3 ANGSTROMS RESOLUTION | | 分子名称: | INOSITOL POLYPHOSPHATE 1-PHOSPHATASE, MAGNESIUM ION | | 著者 | York, J.D, Ponder, J.W, Chen, Z, Mathews, F.S, Majerus, P.W. | | 登録日 | 1994-10-04 | | 公開日 | 1995-01-26 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of inositol polyphosphate 1-phosphatase at 2.3-A resolution.
Biochemistry, 33, 1994
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