3BV9

Structure of Thrombin Bound to the Inhibitor FM19

Summary for 3BV9

• Entry DOI: 10.2210/pdb3bv9/pdb
• Related: 1SFQ
• Related PRD ID: PRD_000276
• Descriptor: Thrombin light chain, Thrombin heavy chain, FM19 inhibitor, ... (7 entities in total)
• Functional Keywords: serine protease, acute phase, blood coagulation, gamma-carboxyglutamic acid, glycoprotein, kringle, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Secreted, extracellular space: P00734 P00734
• Total number of polymer chains: 3
• Total formula weight: 34582.88

Authors

Nieman, M.T.,Burke, F.,Warnock, M.,Zhou, Y.,Sweigert, J.,Chen, A.,Ricketts, D.,Lucchesi, B.R.,Chen, Z.,Di Cera, E.,Hilfinger, J.,Mosberg, H.I.,Schmaier, A.H. (deposition date: 2008-01-05, release date: 2008-03-04, Last modification date: 2023-08-30)

• Primary citation: Nieman, M.T.,Burke, F.,Warnock, M.,Zhou, Y.,Sweigart, J.,Chen, A.,Ricketts, D.,Lucchesi, B.R.,Chen, Z.,Di Cera, E.,Hilfinger, J.,Kim, J.S.,Mosberg, H.I.,Schmaier, A.H.; Thrombostatin FM compounds: direct thrombin inhibitors - mechanism of action in vitro and in vivo.; J.Thromb.Haemost., 6:837-845, 2008; PubMed: 18315550; DOI: 10.1111/j.1538-7836.2008.02937.x

Experimental method

X-RAY DIFFRACTION (1.8 Å)