6PXQ
| Crystal structure of human thrombin mutant D194A | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Thrombin heavy chain, Thrombin light chain | 著者 | Stojanovski, B, Chen, Z, Koester, S.K, Pelc, L.A, Di Cera, E. | 登録日 | 2019-07-26 | 公開日 | 2019-12-18 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Role of the I16-D194 ionic interaction in the trypsin fold. Sci Rep, 9, 2019
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2PGQ
| Human thrombin mutant C191A-C220A in complex with the inhibitor PPACK | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, Thrombin heavy chain, ... | 著者 | Bush-Pelc, L.A, Marino, F, Chen, Z, Pineda, A.O, Mathews, F.S, Di Cera, E. | 登録日 | 2007-04-10 | 公開日 | 2007-07-17 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Important role of the cys-191 cys-220 disulfide bond in thrombin function and allostery J.Biol.Chem., 282, 2007
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2PGB
| Inhibitor-free human thrombin mutant C191A-C220A | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Prothrombin, SULFATE ION | 著者 | Bush-Pelc, L.A, Marino, F, Chen, Z, Pineda, A.O, Mathews, F.S, Di Cera, E. | 登録日 | 2007-04-09 | 公開日 | 2007-07-17 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Important role of the cys-191 cys-220 disulfide bond in thrombin function and allostery J.Biol.Chem., 282, 2007
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2PUX
| Crystal structure of murine thrombin in complex with the extracellular fragment of murine PAR3 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Proteinase-activated receptor 3, Thrombin heavy chain, ... | 著者 | Bah, A, Chen, Z, Bush-Pelc, L.A, Mathews, F.S, Di Cera, E. | 登録日 | 2007-05-09 | 公開日 | 2007-07-10 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4. Proc.Natl.Acad.Sci.Usa, 104, 2007
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1WVE
| p-Cresol Methylhydroxylase: Alteration of the Structure of the Flavoprotein Subunit upon its Binding to the Cytochrome Subunit | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-cresol dehydrogenase [hydroxylating] cytochrome c subunit, 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit, ... | 著者 | Cunane, L.M, Chen, Z.-W, McIntire, W.S, Mathews, F.S. | 登録日 | 2004-12-15 | 公開日 | 2005-03-08 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | p-Cresol Methylhydroxylase: Alteration of the Structure of the Flavoprotein Subunit upon Its Binding to the Cytochrome Subunit Biochemistry, 44, 2005
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1L9E
| Role of Histidine 269 in Catalysis by Monomeric Sarcosine Oxidase | 分子名称: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, IMIDAZOLE, ... | 著者 | Zhao, G, Song, H, Chen, Z.-w, Mathews, F.S, Jorns, M.S. | 登録日 | 2002-03-22 | 公開日 | 2002-08-30 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Monomeric sarcosine oxidase: role of histidine 269 in catalysis. Biochemistry, 41, 2002
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1GG4
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7SR9
| Human alpha-thrombin with 180- and 220- loops replaced with homologous loops from protein C | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, SULFATE ION, ... | 著者 | Di Cera, E, Ruben, E.A, Chen, Z. | 登録日 | 2021-11-08 | 公開日 | 2021-12-08 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The active site region plays a critical role in Na + binding to thrombin. J.Biol.Chem., 298, 2022
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1L9C
| Role of Histidine 269 in Catalysis by Monomeric Sarcosine Oxidase | 分子名称: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, Monomeric Sarcosine Oxidase, ... | 著者 | Zhao, G, Song, H, Chen, Z.-w, Mathews, F.S, Jorns, M.S. | 登録日 | 2002-03-22 | 公開日 | 2002-08-30 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Monomeric sarcosine oxidase: role of histidine 269 in catalysis. Biochemistry, 41, 2002
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1L9D
| Role of Histidine 269 in Catalysis by Monomeric Sarcosine Oxidase | 分子名称: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, Monomeric sarcosine oxidase, ... | 著者 | Zhao, G, Song, H, Chen, Z.-w, Mathews, F.S, Jorns, M.S. | 登録日 | 2002-03-22 | 公開日 | 2002-08-30 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Monomeric sarcosine oxidase: role of histidine 269 in catalysis. Biochemistry, 41, 2002
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6V5T
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6V64
| Crystal structure of human thrombin bound to ppack with tryptophans replaced by 5-F-tryptophan | 分子名称: | D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, SODIUM ION, Thrombin heavy chain, ... | 著者 | Ruben, E.A, Chen, Z, Di Cera, E. | 登録日 | 2019-12-04 | 公開日 | 2020-05-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | 19F NMR reveals the conformational properties of free thrombin and its zymogen precursor prethrombin-2. J.Biol.Chem., 295, 2020
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6A59
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4GQH
| The Conformations and Interactions of the Four-Layer Aggregate Revealed by X-ray Crystallography Diffraction Implied the Importance of Peptides at Opposite Ends in Their Assemblies | 分子名称: | Capsid protein | 著者 | Li, X.Y, Song, B.A, Hu, D.Y, Chen, X, Wang, Z.C, Zeng, M.J, Yu, D.D, Chen, Z, Jin, L.H, Yang, S. | 登録日 | 2012-08-23 | 公開日 | 2013-08-28 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3.06 Å) | 主引用文献 | The Conformations and Interactions of the Four-Layer Aggregate Revealed by X-ray Crystallography Diffraction Implied the Importance of Peptides at Opposite Ends in Their Assemblies To be Published
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1JXP
| BK STRAIN HEPATITIS C VIRUS (HCV) NS3-NS4A | 分子名称: | NS3 SERINE PROTEASE, NS4A, ZINC ION | 著者 | Yan, Y, Munshi, S, Chen, Z. | 登録日 | 1997-08-21 | 公開日 | 1998-01-14 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: a 2.2 A resolution structure in a hexagonal crystal form. Protein Sci., 7, 1998
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7MOA
| Cryo-EM structure of the c-MET II/HGF I complex bound with HGF II in a rigid conformation | 分子名称: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Hepatocyte growth factor, Hepatocyte growth factor receptor | 著者 | Uchikawa, E, Chen, Z.M, Xiao, G.Y, Zhang, X.W, Bai, X.C. | 登録日 | 2021-05-01 | 公開日 | 2021-06-09 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | 主引用文献 | Structural basis of the activation of c-MET receptor. Nat Commun, 12, 2021
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7MOB
| Cryo-EM structure of 2:2 c-MET/NK1 complex | 分子名称: | Hepatocyte growth factor, Hepatocyte growth factor receptor | 著者 | Uchikawa, E, Chen, Z.M, Xiao, G.Y, Zhang, X.W, Bai, X.C. | 登録日 | 2021-05-01 | 公開日 | 2021-06-09 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (5 Å) | 主引用文献 | Structural basis of the activation of c-MET receptor. Nat Commun, 12, 2021
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7MO8
| Cryo-EM structure of 1:1 c-MET I/HGF I complex after focused 3D refinement of holo-complex | 分子名称: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Hepatocyte growth factor, Hepatocyte growth factor receptor | 著者 | Uchikawa, E, Chen, Z.M, Xiao, G.Y, Zhang, X.W, Bai, X.C. | 登録日 | 2021-05-01 | 公開日 | 2021-06-09 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Structural basis of the activation of c-MET receptor. Nat Commun, 12, 2021
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7MO7
| Cryo-EM structure of 2:2 c-MET/HGF holo-complex | 分子名称: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Hepatocyte growth factor, Hepatocyte growth factor receptor | 著者 | Uchikawa, E, Chen, Z.M, Xiao, G.Y, Zhang, X.W, Bai, X.C. | 登録日 | 2021-05-01 | 公開日 | 2021-06-09 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Structural basis of the activation of c-MET receptor. Nat Commun, 12, 2021
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7MO9
| Cryo-EM map of the c-MET II/HGF I/HGF II (K4 and SPH) sub-complex | 分子名称: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Hepatocyte growth factor, Hepatocyte growth factor receptor | 著者 | Uchikawa, E, Chen, Z.M, Xiao, G.Y, Zhang, X.W, Bai, X.C. | 登録日 | 2021-05-01 | 公開日 | 2021-06-09 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structural basis of the activation of c-MET receptor. Nat Commun, 12, 2021
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5HC1
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5HBZ
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1NWO
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8HAZ
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8HBB
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