8JMP
 
 | | Structure of a leaf-branch compost cutinase, ICCG in complex with 1,4-butanediol terephthalate | | 分子名称: | 4-[4-(4-carboxyphenyl)carbonyloxybutoxycarbonyl]benzoic acid, CALCIUM ION, Leaf-branch compost cutinase | | 著者 | Yang, Y, Xue, T, Zheng, Y, Cheng, S, Guo, R.-T, Chen, C.-C. | | 登録日 | 2023-06-05 | | 公開日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Remodeling the polymer-binding cavity to improve the efficacy of PBAT-degrading enzyme.
J Hazard Mater, 464, 2023
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8JMO
 | | Structure of a leaf-branch compost cutinase, ICCG in complex with 4-((4-Hydroxybutoxy)carbonyl)benzoic acid | | 分子名称: | 4-(4-oxidanylbutoxycarbonyl)benzoic acid, CALCIUM ION, Leaf-branch compost cutinase | | 著者 | Yang, Y, Xue, T, Zheng, Y, Cheng, S, Guo, R.-T, Chen, C.-C. | | 登録日 | 2023-06-05 | | 公開日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Remodeling the polymer-binding cavity to improve the efficacy of PBAT-degrading enzyme.
J Hazard Mater, 464, 2023
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4KQX
 | | Mutant Slackia exigua KARI DDV in complex with NAD and an inhibitor | | 分子名称: | HISTIDINE, Ketol-acid reductoisomerase, MAGNESIUM ION, ... | | 著者 | Brinkmann-Chen, S, Flock, T, Cahn, J.K.B, Snow, C.D, Brustad, E.M, Mcintosh, J.A, Meinhold, P, Zhang, L, Arnold, F.H. | | 登録日 | 2013-05-15 | | 公開日 | 2013-06-26 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH.
Proc.Natl.Acad.Sci.USA, 110, 2013
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1ULA
 | | APPLICATION OF CRYSTALLOGRAPHIC AND MODELING METHODS IN THE DESIGN OF PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITORS | | 分子名称: | PURINE NUCLEOSIDE PHOSPHORYLASE, SULFATE ION | | 著者 | Ealick, S.E, Rule, S.A, Carter, D.C, Greenhough, T.J, Babu, Y.S, Cook, W.J, Habash, J, Helliwell, J.R, Stoeckler, J.D, Parksjunior, R.E, Chen, S.-F, Bugg, C.E. | | 登録日 | 1991-11-05 | | 公開日 | 1993-01-15 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors.
Proc.Natl.Acad.Sci.USA, 88, 1991
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1ULB
 | | APPLICATION OF CRYSTALLOGRAPHIC AND MODELING METHODS IN THE DESIGN OF PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITORS | | 分子名称: | GUANINE, PURINE NUCLEOSIDE PHOSPHORYLASE, SULFATE ION | | 著者 | Ealick, S.E, Rule, S.A, Carter, D.C, Greenhough, T.J, Babu, Y.S, Cook, W.J, Habash, J, Helliwell, J.R, Stoeckler, J.D, Parksjunior, R.E, Chen, S.-F, Bugg, C.E. | | 登録日 | 1991-11-05 | | 公開日 | 1993-01-15 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors.
Proc.Natl.Acad.Sci.USA, 88, 1991
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4M1L
 | | Complex of IQCG and Ca2+-bound CaM | | 分子名称: | CALCIUM ION, Calmodulin, IQ domain-containing protein G, ... | | 著者 | Liang, W.X, Chen, L.T, Chen, Z, Chen, S.J, Chen, S. | | 登録日 | 2013-08-03 | | 公開日 | 2014-05-07 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Functional and molecular features of the calmodulin-interacting protein IQCG required for haematopoiesis in zebrafish
Nat Commun, 5, 2014
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4LZX
 | | Complex of IQCG and Ca2+-free CaM | | 分子名称: | Calmodulin, IQ domain-containing protein G, SULFATE ION | | 著者 | Liang, W.X, Chen, L.T, Chen, Z, Chen, S.J, Chen, S. | | 登録日 | 2013-08-01 | | 公開日 | 2014-05-07 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Functional and molecular features of the calmodulin-interacting protein IQCG required for haematopoiesis in zebrafish
Nat Commun, 5, 2014
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5FNA
 | | Cryo-EM reconstruction of caspase-1 CARD | | 分子名称: | Caspase-1 | | 著者 | Li, Y, Lu, A, Schmidt, F.I, Yin, Q, Chen, S, Fu, T.M, Tong, A.B, Ploegh, H.L, Mao, Y, Wu, H. | | 登録日 | 2015-11-11 | | 公開日 | 2016-03-30 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | | 主引用文献 | Molecular Basis of Caspase-1 Polymerization and its Inhibition by a Novel Capping Mechanism
Nat.Struct.Mol.Biol., 23, 2016
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4KQW
 | | The structure of the Slackia exigua KARI in complex with NADP | | 分子名称: | Ketol-acid reductoisomerase, L(+)-TARTARIC ACID, MAGNESIUM ION, ... | | 著者 | Brinkmann-Chen, S, Flock, T, Cahn, J.K.B, Snow, C.D, Brustad, E.M, Mcintosh, J.A, Meinhold, P, Zhang, L, Arnold, F.H. | | 登録日 | 2013-05-15 | | 公開日 | 2013-06-26 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.39 Å) | | 主引用文献 | General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH.
Proc.Natl.Acad.Sci.USA, 110, 2013
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5GOV
 | | Crystal Structure of MCR-1, a phosphoethanolamine transferase, extracellular domain | | 分子名称: | Probable phosphatidylethanolamine transferase Mcr-1, ZINC ION | | 著者 | Hu, M, Guo, J, Chen, S, Hao, Q. | | 登録日 | 2016-07-29 | | 公開日 | 2016-12-21 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | | 主引用文献 | Crystal Structure of Escherichia coli originated MCR-1, a phosphoethanolamine transferase for Colistin Resistance.
Sci Rep, 6, 2016
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1H69
 | | CRYSTAL STRUCTURE OF HUMAN NAD[P]H-QUINONE OXIDOREDUCTASE CO WITH 2,3,5,6,TETRAMETHYL-P-BENZOQUINONE (DUROQUINONE) AT 2.5 ANGSTROM RESOLUTION | | 分子名称: | 3-(HYDROXYMETHYL)-1-METHYL-5-(2-METHYLAZIRIDIN-1-YL)-2-PHENYL-1H-INDOLE-4,7-DIONE, FLAVIN-ADENINE DINUCLEOTIDE, NAD(P)H DEHYDROGENASE [QUINONE] 1 | | 著者 | Faig, M, Bianchet, M.A, Chen, S, Winski, S, Ross, D, Amzel, L.M. | | 登録日 | 2001-06-08 | | 公開日 | 2001-09-05 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Structure-Based Development of Anticancer Drugs: Complexes of Nad(P)H:Quinone Oxidoreductase 1 with Chemotherapeutic Quinones
Structure, 9, 2001
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2MOA
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2H53
 | | Multiple distinct assemblies reveal conformational flexibility in the small heat shock protein Hsp26 | | 分子名称: | small heat shock protein Hsp26 | | 著者 | White, H.E, Orlova, E.V, Chen, S, Wang, L, Ignatiou, A, Gowen, B, Stromer, T, Franzmann, T.M, Haslbeck, M, Buchner, J, Saibil, H.R. | | 登録日 | 2006-05-25 | | 公開日 | 2006-08-01 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (11.5 Å) | | 主引用文献 | Multiple distinct assemblies reveal conformational flexibility in the small heat shock protein hsp26
Structure, 14, 2006
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2H50
 | | Multiple distinct assemblies reveal conformational flexibility in the small heat shock protein Hsp26 | | 分子名称: | small heat shock protein Hsp26 | | 著者 | White, H.E, Orlova, E.V, Chen, S, Wang, L, Ignatiou, A, Gowen, B, Stromer, T, Franzmann, T.M, Haslbeck, M, Buchner, J, Saibil, H.R. | | 登録日 | 2006-05-25 | | 公開日 | 2006-08-01 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (10.8 Å) | | 主引用文献 | Multiple distinct assemblies reveal conformational flexibility in the small heat shock protein hsp26
Structure, 14, 2006
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4GLY
 | | Human urokinase-type plasminogen activator uPA in complex with the two-disulfide bridge peptide UK504 | | 分子名称: | BICYCLIC PEPTIDE INHIBITOR UK504, CHLORIDE ION, GLYCEROL, ... | | 著者 | Buth, S.A, Leiman, P.G, Chen, S, Heinis, C. | | 登録日 | 2012-08-15 | | 公開日 | 2013-05-15 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.518 Å) | | 主引用文献 | Bicyclic Peptide Ligands Pulled out of Cysteine-Rich Peptide Libraries.
J.Am.Chem.Soc., 135, 2013
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4JK5
 | | Human urokinase-type Plasminogen Activator (uPA) in complex with a bicyclic peptide inhibitor (UK18-D-Ser) | | 分子名称: | 1,3,5-tris(bromomethyl)benzene, CHLORIDE ION, HEXAETHYLENE GLYCOL, ... | | 著者 | Buth, S.A, Leiman, P.G, Chen, S, Heinis, C. | | 登録日 | 2013-03-09 | | 公開日 | 2013-07-17 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Improving binding affinity and stability of Peptide ligands by substituting glycines with d-amino acids.
Chembiochem, 14, 2013
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4JK6
 | | Human urokinase-type Plasminogen Activator (uPA) in complex with a bicyclic peptide inhibitor (UK18-D-Aba) | | 分子名称: | 1,3,5-tris(bromomethyl)benzene, CHLORIDE ION, HEXAETHYLENE GLYCOL, ... | | 著者 | Buth, S.A, Leiman, P.G, Chen, S, Heinis, C. | | 登録日 | 2013-03-09 | | 公開日 | 2013-07-17 | | 最終更新日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Improving binding affinity and stability of Peptide ligands by substituting glycines with d-amino acids.
Chembiochem, 14, 2013
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6LKA
 | | Crystal Structure of EV71-3C protease with a Novel Macrocyclic Compounds | | 分子名称: | 3C proteinase, ~{N}-[(2~{S})-1-[[(2~{S},3~{S},6~{S},7~{Z},12~{E})-4,9-bis(oxidanylidene)-6-[[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]methyl]-2-phenyl-1,10-dioxa-5-azacyclopentadeca-7,12-dien-3-yl]amino]-3-methyl-1-oxidanylidene-butan-2-yl]-5-methyl-1,2-oxazole-3-carboxamide | | 著者 | Li, P, Wu, S.Q, Xiao, T.Y.C, Li, Y.L, Su, Z.M, Hao, F, Hu, G.P, Hu, J, Lin, F.S, Chen, X.S, Gu, Z.X, He, H.Y, Li, J, Chen, S.H. | | 登録日 | 2019-12-18 | | 公開日 | 2020-06-17 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.033 Å) | | 主引用文献 | Design, synthesis, and evaluation of a novel macrocyclic anti-EV71 agent.
Bioorg.Med.Chem., 28, 2020
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6JFK
 | | GDP bound Mitofusin2 (MFN2) | | 分子名称: | CITRIC ACID, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Li, Y.J, Cao, Y.L, Feng, J.X, Qi, Y.B, Meng, S.X, Yang, J.F, Zhong, Y.T, Kang, S.S, Chen, X.X, Lan, L, Luo, L, Yu, B, Chen, S.D, Chan, D.C, Hu, J.J, Gao, S. | | 登録日 | 2019-02-10 | | 公開日 | 2019-11-13 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.997 Å) | | 主引用文献 | Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset.
Nat Commun, 10, 2019
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4J1L
 | | Mutant Endotoxin TeNT | | 分子名称: | Tetanus toxin, ZINC ION | | 著者 | Guo, J, Pan, X, Zhao, Y, Chen, S. | | 登録日 | 2013-02-01 | | 公開日 | 2014-02-05 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Engineering Clostridia Neurotoxins with elevated catalytic activity
Toxicon, 74, 2013
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4PFE
 | | Crystal structure of vsfGFP-0 | | 分子名称: | Green fluorescent protein | | 著者 | Jauch, R, Chen, S.L. | | 登録日 | 2014-04-29 | | 公開日 | 2015-06-24 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.603 Å) | | 主引用文献 | Rational Structure-Based Design of Bright GFP-Based Complexes with Tunable Dimerization.
Angew.Chem.Int.Ed.Engl., 54, 2015
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6JFL
 | | Nucleotide-free Mitofusin2 (MFN2) | | 分子名称: | CALCIUM ION, GLYCEROL, Mitofusin-2,cDNA FLJ57997, ... | | 著者 | Li, Y.J, Cao, Y.L, Feng, J.X, Qi, Y.B, Meng, S.X, Yang, J.F, Zhong, Y.T, Kang, S.S, Chen, X.X, Lan, L, Luo, L, Yu, B, Chen, S.D, Chan, D.C, Hu, J.J, Gao, S. | | 登録日 | 2019-02-10 | | 公開日 | 2019-11-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.806 Å) | | 主引用文献 | Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset.
Nat Commun, 10, 2019
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6JFM
 | | Mitofusin2 (MFN2)_T111D | | 分子名称: | ACETATE ION, CALCIUM ION, Mitofusin-2,Mitofusin-2 | | 著者 | Li, Y.J, Cao, Y.L, Feng, J.X, Qi, Y.B, Meng, S.X, Yang, J.F, Zhong, Y.T, Kang, S.S, Chen, X.X, Lan, L, Luo, L, Yu, B, Chen, S.D, Chan, D.C, Hu, J.J, Gao, S. | | 登録日 | 2019-02-10 | | 公開日 | 2019-11-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset.
Nat Commun, 10, 2019
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4GPO
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4KYH
 | | Crystal structure of mouse glyoxalase I complexed with zopolrestat | | 分子名称: | 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID, Lactoylglutathione lyase, ZINC ION | | 著者 | Zhai, J, Yuan, M, Zhang, L, Chen, Y, Zhang, H, Chen, S, Zhao, Y. | | 登録日 | 2013-05-29 | | 公開日 | 2013-08-07 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Zopolrestat as a human glyoxalase I inhibitor and its structural basis.
Chemmedchem, 8, 2013
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