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PDB: 142 件
4RVR
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Crystal Structure of the bromodomain of human BAZ2B in complex WITH GSK2801
分子名称: 1,2-ETHANEDIOL, 1-{1-[2-(methylsulfonyl)phenyl]-7-propoxyindolizin-3-yl}ethanone, Bromodomain adjacent to zinc finger domain protein 2B
著者Chaikuad, A, Felletar, I, Chung, C.W, Drewry, D, Chen, P, Filippakopoulos, P, Fedorov, O, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
登録日2014-11-27
公開日2014-12-10
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.
J.Med.Chem., 59, 2016
4A7X
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Crystal structure of uridylate kinase from Helicobacter pylori
分子名称: URIDINE-5'-DIPHOSPHATE, URIDYLATE KINASE
著者Chu, C.H, Liu, M.H, Chen, P.C, Sun, Y.J.
登録日2011-11-15
公開日2012-06-27
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Structures of Helicobacter Pylori Uridylate Kinase: Insight Into Release of the Product Udp
Acta Crystallogr.,Sect.D, 68, 2012
1E0Q
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Mutant Peptide from the first N-terminal 17 amino-acid of Ubiquitin
分子名称: POLYUBIQUITIN-B
著者Zerella, R, Chen, P.Y, Evans, P.A, Raine, A, Williams, D.H.
登録日2000-04-05
公開日2001-01-16
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Structural Characterization of a Mutant Peptide Derived from Ubiquitin: Implications for Protein Folding.
Protein Sci., 9, 2000
1D9X
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CRYSTAL STRUCTURE OF THE DNA REPAIR PROTEIN UVRB
分子名称: EXCINUCLEASE UVRABC COMPONENT UVRB, ZINC ION
著者Theis, K, Chen, P.J, Skorvaga, M, Van Houten, B, Kisker, C.
登録日1999-10-30
公開日2000-05-03
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal structure of UvrB, a DNA helicase adapted for nucleotide excision repair.
EMBO J., 18, 1999
1D9Z
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CRYSTAL STRUCTURE OF THE DNA REPAIR PROTEIN UVRB IN COMPLEX WITH ATP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, EXCINUCLEASE UVRABC COMPONENT UVRB, MAGNESIUM ION, ...
著者Theis, K, Chen, P.J, Skorvaga, M, Van Houten, B, Kisker, C.
登録日1999-10-30
公開日2000-05-03
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Crystal structure of UvrB, a DNA helicase adapted for nucleotide excision repair.
EMBO J., 18, 1999
4EO7
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BU of 4eo7 by Molmil
Crystal structure of the TIR domain of human myeloid differentiation primary response protein 88.
分子名称: MAGNESIUM ION, Myeloid differentiation primary response protein MyD88
著者Snyder, G.A, Cirl, C, Jiang, J.S, Chen, P, Smith, T, Xiao, T.S.
登録日2012-04-13
公開日2013-04-10
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.449 Å)
主引用文献Molecular mechanisms for the subversion of MyD88 signaling by TcpC from virulent uropathogenic Escherichia coli.
Proc.Natl.Acad.Sci.USA, 110, 2013
4A7W
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BU of 4a7w by Molmil
Crystal structure of uridylate kinase from Helicobacter pylori
分子名称: GLYCEROL, GUANOSINE-5'-TRIPHOSPHATE, URIDYLATE KINASE
著者Chu, C.H, Chen, P.C, Liu, M.H, Sun, Y.J.
登録日2011-11-15
公開日2012-06-27
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structures of Helicobacter Pylori Uridylate Kinase: Insight Into Release of the Product Udp
Acta Crystallogr.,Sect.D, 68, 2012
2LGL
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BU of 2lgl by Molmil
NMR structure of the UHRF1 PHD domain
分子名称: E3 ubiquitin-protein ligase UHRF1, ZINC ION
著者Wang, C, Shen, J, Yang, Z, Chen, P, Zhao, B, Hu, W, Lan, W, Tong, X, Wu, H, Li, G, Cao, C.
登録日2011-07-28
公開日2011-09-28
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Structural basis for site-specific reading of unmodified R2 of histone H3 tail by UHRF1 PHD finger.
Cell Res., 21, 2011
4IR4
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Crystal Structure of the bromodomain of human BAZ2B in complex with 1-[7-(morpholin-4-yl)-1-(pyridin-2-yl)indolizin-3-yl]ethanone (GSK2834113A)
分子名称: 1,2-ETHANEDIOL, 1-[7-(morpholin-4-yl)-1-(pyridin-2-yl)indolizin-3-yl]ethanone, Bromodomain adjacent to zinc finger domain protein 2B
著者Chaikuad, A, Felletar, I, Chung, C.W, Drewry, D, Chen, P, Filippakopoulos, P, Fedorov, O, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
登録日2013-01-14
公開日2013-01-23
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.
J.Med.Chem., 59, 2016
4IR5
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Crystal Structure of the bromodomain of human BAZ2B in complex with 1-{1-[2-(hydroxymethyl)phenyl]-7-phenoxyindolizin-3-yl}ethanone (GSK2847449A)
分子名称: 1,2-ETHANEDIOL, 1-{1-[2-(hydroxymethyl)phenyl]-7-phenoxyindolizin-3-yl}ethanone, Bromodomain adjacent to zinc finger domain protein 2B
著者Chaikuad, A, Felletar, I, Chung, C.W, Drewry, D, Chen, P, Filippakopoulos, P, Fedorov, O, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
登録日2013-01-14
公開日2013-01-23
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.
J.Med.Chem., 59, 2016
4IR3
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BU of 4ir3 by Molmil
Crystal Structure of the bromodomain of human BAZ2B in complex with 1-[7-amino-1-(pyrimidin-2-yl)indolizin-3-yl]ethanone (GSK2833282A)
分子名称: 1,2-ETHANEDIOL, 1-[7-amino-1-(pyrimidin-2-yl)indolizin-3-yl]ethanone, Bromodomain adjacent to zinc finger domain protein 2B, ...
著者Chaikuad, A, Felletar, I, Chung, C.W, Drewry, D, Chen, P, Filippakopoulos, P, Fedorov, O, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
登録日2013-01-14
公開日2013-01-23
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.
J.Med.Chem., 59, 2016
4IR6
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BU of 4ir6 by Molmil
Crystal Structure of the bromodomain of human BAZ2B in complex with 1-{1-[2-(METHYLSULFONYL)PHENYL]-7-PHENOXYINDOLIZIN-3-YL}ETHANONE (GSK2838097A)
分子名称: 1,2-ETHANEDIOL, 1-{1-[2-(methylsulfonyl)phenyl]-7-phenoxyindolizin-3-yl}ethanone, Bromodomain adjacent to zinc finger domain protein 2B
著者Chaikuad, A, Felletar, I, Chung, C.W, Drewry, D, Chen, P, Filippakopoulos, P, Fedorov, O, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
登録日2013-01-14
公開日2013-01-23
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.
J.Med.Chem., 59, 2016
2JRY
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BU of 2jry by Molmil
Structure and Sodium Channel Activity of an Excitatory I1-Superfamily Conotoxin
分子名称: I-superfamily conotoxin r11a
著者Buczek, O, Wei, D, Babon, J, Yang, X, Fiedler, B, Chen, P, Yoshikami, D, Olivera, B, Bulaj, G, Norton, R.
登録日2007-06-29
公開日2007-10-23
最終更新日2022-03-09
実験手法SOLUTION NMR
主引用文献Structure and sodium channel activity of an excitatory I1-superfamily conotoxin.
Biochemistry, 46, 2007
6Z14
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BU of 6z14 by Molmil
Structure of Bifidobacterium bifidum GH20 beta-N-beta-N-acetylhexosaminidase E553Q variant in complex with 4MU-6SGlcNAc-derived oxazoline
分子名称: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Beta-N-acetylhexosaminidase, NITRATE ION, ...
著者He, Y, Jin, Y, Rizkallah, P, Chen, P.
登録日2020-05-12
公開日2021-05-19
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献Structure and activity of the GH20 beta-N-beta-N-acetylhexosaminidase from Bifidobacterium bifidum
To Be Published
2LGK
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BU of 2lgk by Molmil
NMR Structure of UHRF1 PHD domains in a complex with histone H3 peptide
分子名称: E3 ubiquitin-protein ligase UHRF1, ZINC ION, histone H3 peptide
著者Wang, C, Shen, J, Yang, Z, Chen, P, Zhao, B, Hu, W, Lan, W, Tong, X, Wu, H, Li, G, Cao, C.
登録日2011-07-28
公開日2011-09-28
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Structural basis for site-specific reading of unmodified R2 of histone H3 tail by UHRF1 PHD finger.
Cell Res., 21, 2011
2LGG
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BU of 2lgg by Molmil
Structure of PHD domain of UHRF1 in complex with H3 peptide
分子名称: E3 ubiquitin-protein ligase UHRF1, ZINC ION, histone H3 peptide
著者Wang, C, Shen, J, Yang, Z, Chen, P, Zhao, B, Hu, W, Lan, W, Tong, X, Wu, H, Li, G, Cao, C.
登録日2011-07-26
公開日2011-09-28
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Structural basis for site-specific reading of unmodified R2 of histone H3 tail by UHRF1 PHD finger.
Cell Res., 21, 2011
4OU6
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BU of 4ou6 by Molmil
Crystal structure of DnaT84-153-dT10 ssDNA complex form 1
分子名称: DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), Primosomal protein 1
著者Liu, Z, Chen, P, Niu, L, Teng, M, Li, X.
登録日2014-02-15
公開日2014-08-13
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Crystal structure of DnaT84-153-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode.
Nucleic Acids Res., 42, 2014
4HGA
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BU of 4hga by Molmil
Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX
分子名称: Death domain-associated protein 6, Histone H3.3, Histone H4, ...
著者Liu, C.P, Xiong, C.Y, Wang, M.Z, Yu, Z.L, Yang, N, Chen, P, Zhang, Z.G, Li, G.H, Xu, R.M.
登録日2012-10-07
公開日2012-11-07
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.799 Å)
主引用文献Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX.
Nat.Struct.Mol.Biol., 19, 2012
4OU7
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Crystal structure of DnaT84-153-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode
分子名称: DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), Primosomal protein 1
著者Liu, Z, Chen, P, Niu, L, Teng, M, Li, X.
登録日2014-02-15
公開日2014-08-13
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.83 Å)
主引用文献Crystal structure of DnaT84-153-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode.
Nucleic Acids Res., 42, 2014
3SR4
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BU of 3sr4 by Molmil
Crystal Structure of Human DOT1L in Complex with a Selective Inhibitor
分子名称: (2S)-2-azanyl-4-[[(2S,3S,4R,5R)-5-[6-(methylamino)purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, ACETATE ION, GLYCEROL, ...
著者Diao, J, Chen, P, Yao, Y, Prasad, B.V.V, Song, Y.
登録日2011-07-06
公開日2011-10-05
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Selective Inhibitors of Histone Methyltransferase DOT1L: Design, Synthesis, and Crystallographic Studies.
J.Am.Chem.Soc., 133, 2011
4H6J
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BU of 4h6j by Molmil
Identification of Cys 255 in HIF-1 as a novel site for development of covalent inhibitors of HIF-1 /ARNT PasB domain protein-protein interaction.
分子名称: ARYL HYDROCARBON NUCLEAR TRANSLOCATOR, HYPOXIA INDUCIBLE FACTOR 1-ALPHA
著者Cardoso, R, Love, R.A, Nilsson, C, Bergqvist, S, Nowlin, D, Yan, J, Liu, K, Zhu, J, Chen, P, Deng, Y.-L, Dyson, H.J, Greig, M.J, Brooun, A.
登録日2012-09-19
公開日2012-12-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献Identification of Cys255 in HIF-1 alpha as a novel site for development of covalent inhibitors of HIF-1 alpha /ARNT PasB domain protein-protein interaction.
Protein Sci., 21, 2012
6AEZ
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BU of 6aez by Molmil
Crystal structure of human CCL5 trimer
分子名称: C-C motif chemokine 5, SULFATE ION
著者Chen, Y.C, Li, K.M, Chen, P.J, Zarivach, R, Sun, Y.J, Sue, S.C.
登録日2018-08-07
公開日2019-08-07
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Integrative Model to Coordinate the Oligomerization and Aggregation Mechanisms of CCL5.
J.Mol.Biol., 432, 2020
5EXE
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BU of 5exe by Molmil
Crystal structure of oxalate oxidoreductase from Moorella thermoacetica bound with carboxy-TPP adduct
分子名称: IRON/SULFUR CLUSTER, MAGNESIUM ION, Oxalate oxidoreductase subunit alpha, ...
著者Gibson, M.I, Chen, P.Y.-T, Drennan, C.L.
登録日2015-11-23
公開日2015-12-30
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献One-carbon chemistry of oxalate oxidoreductase captured by X-ray crystallography.
Proc.Natl.Acad.Sci.USA, 113, 2016
5EXD
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BU of 5exd by Molmil
Crystal structure of oxalate oxidoreductase from Moorella thermoacetica bound with carboxy-di-oxido-methyl-TPP (COOM-TPP) intermediate
分子名称: IRON/SULFUR CLUSTER, MAGNESIUM ION, Oxalate oxidoreductase subunit alpha, ...
著者Gibson, M.I, Chen, P.Y.-T, Drennan, C.L.
登録日2015-11-23
公開日2015-12-30
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献One-carbon chemistry of oxalate oxidoreductase captured by X-ray crystallography.
Proc.Natl.Acad.Sci.USA, 113, 2016
7MLK
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Crystal structure of human PI3Ka (p110a subunit) with MMV085400 bound to the active site determined at 2.9 angstroms resolution
分子名称: 4-[6-(3,4,5-trimethoxyanilino)pyrazin-2-yl]benzamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
著者Krake, S.H, Martinez, P.D.G, Poggi, M.L, Ferreira, M.S, Aguiar, A.C.C, Souza, G.E, Wenlock, M, Jones, B, Steinbrecher, T, Day, T, McPhail, J, Burke, J, Yeo, T, Mok, S, Uhlemann, A.C, Fidock, D.A, Chen, P, Grodsky, N, Deng, Y.L, Guido, R.V.C, Campbell, S.F, Willis, P.A, Dias, L.C.
登録日2021-04-28
公開日2022-05-04
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.91 Å)
主引用文献Discovery of 2,6-disubstituted pyrazines as potent PI4K inhibitors with antimalarial activity
To Be Published

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