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PDB: 710 results
7CLD
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BU of 7cld by Molmil
Crystal structure of T2R-TTL-Cevipabulin complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-[2,6-bis(fluoranyl)-4-[3-(methylamino)propoxy]phenyl]-5-chloranyl-N-[(2S)-1,1,1-tris(fluoranyl)propan-2-yl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, CALCIUM ION, ...
Authors:Chen, L.J, Chen, Q, Yu, Y, Yang, J.H.
Deposit date:2020-07-20
Release date:2021-07-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.611 Å)
Cite:Cevipabulin-tubulin complex reveals a novel agent binding site on alpha-tubulin with tubulin degradation effect.
Sci Adv, 7, 2021
7DP8
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BU of 7dp8 by Molmil
Crystal structure of T2R-TTL-Cevipabulin-eribulin complex
Descriptor: (1S,3S,6S,9S,12S,14R,16R,18S,20R,21R,22S,26R,29S,31R,32S,33R,35R,36S)-20-[(2S)-3-amino-2-hydroxypropyl]-21-methoxy-14-methyl-8,15-dimethylidene-2,19,30,34,37,39,40,41-octaoxanonacyclo[24.9.2.1~3,32~.1~3,33~.1~6,9~.1~12,16~.0~18,22~.0~29,36~.0~31,35~]hentetracontan-24-one (non-preferred name), 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-[2,6-bis(fluoranyl)-4-[3-(methylamino)propoxy]phenyl]-5-chloranyl-N-[(2S)-1,1,1-tris(fluoranyl)propan-2-yl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, ...
Authors:Chen, L.J, Chen, Q, Yu, Y, Yang, J.H.
Deposit date:2020-12-18
Release date:2021-07-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.446 Å)
Cite:Cevipabulin-tubulin complex reveals a novel agent binding site on alpha-tubulin with tubulin degradation effect.
Sci Adv, 7, 2021
6BV3
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BU of 6bv3 by Molmil
Crystal structure of porcine aminopeptidase-N with Leucine
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Chen, L, Lin, Y.-L, Li, F.
Deposit date:2017-12-12
Release date:2018-01-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach.
Sci Rep, 7, 2017
6BV0
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BU of 6bv0 by Molmil
Crystal structure of porcine aminopeptidase-N with Arginine
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Chen, L, Lin, Y.-L, Li, F.
Deposit date:2017-12-12
Release date:2018-01-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:The Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach.
Sci Rep, 7, 2017
6BV1
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BU of 6bv1 by Molmil
Crystal structure of porcine aminopeptidase-N with Aspartic acid
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Chen, L, Lin, Y.-L, Li, F.
Deposit date:2017-12-12
Release date:2018-01-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach.
Sci Rep, 7, 2017
6BV4
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BU of 6bv4 by Molmil
Crystal structure of porcine aminopeptidase-N with Methionine
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Chen, L, Lin, Y.-L, Li, F.
Deposit date:2017-12-12
Release date:2018-01-10
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:The Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach.
Sci Rep, 7, 2017
6BUY
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BU of 6buy by Molmil
Crystal structure of porcine aminopeptidase-N with Glycine
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Chen, L, Lin, Y.-L, Li, F.
Deposit date:2017-12-11
Release date:2018-01-10
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach.
Sci Rep, 7, 2017
6BV2
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BU of 6bv2 by Molmil
Crystal structure of porcine aminopeptidase-N with Isoleucine
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Chen, L, Lin, Y.-L, Li, F.
Deposit date:2017-12-12
Release date:2018-01-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:The Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach.
Sci Rep, 7, 2017
3MQ0
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BU of 3mq0 by Molmil
Crystal Structure of Agobacterium tumefaciens repressor BlcR
Descriptor: Transcriptional repressor of the blcABC operon
Authors:Chen, L.
Deposit date:2010-04-27
Release date:2011-03-30
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.793 Å)
Cite:The Agrobacterium tumefaciens Transcription Factor BlcR Is Regulated via Oligomerization.
J.Biol.Chem., 286, 2011
3RJ2
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BU of 3rj2 by Molmil
Structural and functional characterization of a novel histone H3 binding protein ORF158L from the Singapore grouper iridovirus (SGIV)
Descriptor: Putative uncharacterized protein
Authors:Chen, L, Liu, Y, Sivaraman, J, Hew, C.L.
Deposit date:2011-04-15
Release date:2012-02-29
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Novel histone H3 binding protein ORF158L from the Singapore grouper iridovirus
J.Virol., 85, 2011
3LLP
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BU of 3llp by Molmil
1.8 Angstrom human fascin 1 crystal structure
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BROMIDE ION, Fascin, ...
Authors:Chen, L, Yang, S, Jakoncic, J, Zhang, J.J, Huang, X.-Y.
Deposit date:2010-01-29
Release date:2010-04-07
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Migrastatin analogues target fascin to block tumour metastasis.
Nature, 464, 2010
7CDA
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BU of 7cda by Molmil
Crystal structure of T2R-TTL-PAC complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ...
Authors:Chen, L.J, Chen, Q, Yu, Y, Yang, J.H.
Deposit date:2020-06-19
Release date:2021-06-23
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.659 Å)
Cite:Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond.
J.Med.Chem., 65, 2022
7CEK
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BU of 7cek by Molmil
Crystal structure of T2R-TTL-BML-284 complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, CHLORIDE ION, ...
Authors:Chen, L.J, Chen, Q, Yu, Y, Yang, J.H.
Deposit date:2020-06-23
Release date:2021-06-23
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.696 Å)
Cite:Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond.
J.Med.Chem., 65, 2022
3RPT
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BU of 3rpt by Molmil
Crystal structure of the anti-HIV b12 scaffold protein
Descriptor: Endoglucanase E-2, SULFATE ION
Authors:Chen, L, Kwong, P.D.
Deposit date:2011-04-27
Release date:2011-12-21
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.303 Å)
Cite:Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold.
Science, 334, 2011
7CE6
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BU of 7ce6 by Molmil
Crystal structure of T2R-TTL-Compound9 complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ...
Authors:Chen, L.J, Chen, Q, Yu, Y, Yang, J.H.
Deposit date:2020-06-22
Release date:2021-06-30
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.695 Å)
Cite:Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond.
J.Med.Chem., 65, 2022
7C34
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BU of 7c34 by Molmil
Crystal structure of Serratia marcescens Chitinase B complexed with Berberine
Descriptor: BERBERINE, Chitinase
Authors:Chen, L, Chen, J, Yang, Q.
Deposit date:2020-05-11
Release date:2020-05-27
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.938 Å)
Cite:Crystal structure-guided design of berberine-based novel chitinase inhibitors.
J Enzyme Inhib Med Chem, 35, 2020
2M1N
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BU of 2m1n by Molmil
Solution structure of a chaperone in type III secretion system
Descriptor: Type III secretion system filament chaperone CesA
Authors:Chen, L, Economou, A, Kalodimos, C.
Deposit date:2012-12-03
Release date:2013-04-10
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Substrate-Activated Conformational Switch on Chaperones Encodes a Targeting Signal in Type III Secretion.
Cell Rep, 3, 2013
6JB1
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BU of 6jb1 by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with repaglinide and ATPgammaS at 3.3A resolution
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
Authors:Chen, L, Ding, D, Wang, M, Wu, J.-X, Kang, Y.
Deposit date:2019-01-25
Release date:2019-05-22
Last modified:2021-09-29
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:The Structural Basis for the Binding of Repaglinide to the Pancreatic KATPChannel.
Cell Rep, 27, 2019
2P8T
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BU of 2p8t by Molmil
Hypothetical protein PH0730 from Pyrococcus horikoshii OT3
Descriptor: Hypothetical protein PH0730
Authors:Chen, L, Zhao, M, Ebihara, A, Shinkai, A, Kuramitsu, S, Yokoyama, S, Zhu, J, Swindell, J.T, Fu, Z.-Q, Chrzas, J, Rose, J.P, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG), RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-03-23
Release date:2007-04-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Hypothetical protein PH0730 from Pyrococcus horikoshii OT3
To be Published
2P91
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BU of 2p91 by Molmil
Crystal structure of Enoyl-[acyl-carrier-protein] reductase (NADH) from Aquifex aeolicus VF5
Descriptor: Enoyl-[acyl-carrier-protein] reductase [NADH]
Authors:Chen, L, Li, Y, Ebihara, A, Shinkai, A, Kuramitsu, S, Yokoyama, S, Zhao, M, Rose, J.P, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG), RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-03-23
Release date:2007-04-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of Enoyl-[acyl-carrier-protein] reductase (NADH) from Aquifex aeolicus VF5
To be Published
5XSK
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BU of 5xsk by Molmil
Crystal structure of PWWP-DNA complex for human hepatoma-derived growth factor
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, DNA (5'-D(P*TP*GP*GP*TP*CP*TP*TP*GP*AP*A)-3'), DNA (5'-D(P*TP*TP*CP*AP*AP*GP*AP*CP*CP*A)-3'), ...
Authors:Chen, L.Y, Huang, Y.C, Hsieh, Y.C, Lin, P.J, Chen, C.J.
Deposit date:2017-06-14
Release date:2018-06-20
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Structure of PWWP-DNA complex at 2.84 Angstroms resolution
To Be Published
5XSL
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BU of 5xsl by Molmil
Crystal structure of the PWWP domain of human hepatoma-derived growth factor
Descriptor: Hepatoma-derived growth factor
Authors:Chen, L.Y, Huang, Y.C, Hsieh, Y.C, Lin, P.J, Chen, C.J.
Deposit date:2017-06-14
Release date:2018-06-20
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure of the PWWP domain at 3.3 Angstroms resolution
To Be Published
3RJQ
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BU of 3rjq by Molmil
Crystal structure of anti-HIV llama VHH antibody A12 in complex with C186 gp120
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, C186 gp120, Llama VHH A12
Authors:Chen, L, McLellan, J.S, Kwon, Y.D, Schmidt, S, Wu, X, Zhou, T, Yang, Y, Zhang, B, Forsman, A, Weiss, R.A, Verrips, T, Mascola, J, Kwong, P.D.
Deposit date:2011-04-15
Release date:2012-05-02
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Crystal structure of anti-HIV A12 VHH of llama antibody in complex with C1086 gp120
To be Published
3R0M
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BU of 3r0m by Molmil
Crystal structure of anti-HIV llama VHH antibody A12
Descriptor: Llama VHH A12, SULFATE ION
Authors:Chen, L, McLellan, J.S, Kwon, Y.D, Schmidt, S, Wu, X, Zhou, T, Yang, Y, Zhang, B, Forsman, A, Weiss, R.A, Verrips, T, Mascola, J, Kwong, P.D.
Deposit date:2011-03-08
Release date:2012-03-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Single-Headed Immunoglobulins Efficiently Penetrate CD4-Binding Site and Effectively Neutralize HIV-1
To be Published
3MCA
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BU of 3mca by Molmil
Structure of the Dom34-Hbs1 Complex and implications for its role in No-Go decay
Descriptor: Elongation factor 1 alpha-like protein, Protein dom34
Authors:Chen, L, Song, H.
Deposit date:2010-03-28
Release date:2010-10-06
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Structure of the Dom34-Hbs1 complex and implications for no-go decay
Nat.Struct.Mol.Biol., 17, 2010

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