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PDB: 710 件
6JPF
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BU of 6jpf by Molmil
Structure of atOSCA1.1 channel at 3.52A
分子名称: Protein OSCA1
著者Chen, L, Zhang, M, Kang, Y, Wu, J.X.
登録日2019-03-26
公開日2019-04-10
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.52 Å)
主引用文献Structure of the mechanosensitive OSCA channels.
Nat. Struct. Mol. Biol., 25, 2018
6JB3
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BU of 6jb3 by Molmil
Structure of SUR1 subunit bound with repaglinide
分子名称: ATP-binding cassette sub-family C member 8 isoform X2, Digitonin, Repaglinide
著者Chen, L, Ding, D, Wang, M, Wu, J.-X, Kang, Y.
登録日2019-01-25
公開日2019-05-22
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.53 Å)
主引用文献The Structural Basis for the Binding of Repaglinide to the Pancreatic KATPChannel.
Cell Rep, 27, 2019
6JT2
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BU of 6jt2 by Molmil
Structure of human soluble guanylate cyclase in the NO activated state
分子名称: Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ...
著者Chen, L, Kang, Y, Liu, R, Wu, J.-X.
登録日2019-04-08
公開日2019-09-04
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structural insights into the mechanism of human soluble guanylate cyclase.
Nature, 574, 2019
6JT0
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BU of 6jt0 by Molmil
Structure of human soluble guanylate cyclase in the unliganded state
分子名称: Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, PROTOPORPHYRIN IX CONTAINING FE
著者Chen, L, Kang, Y, Liu, R, Wu, J.-X.
登録日2019-04-08
公開日2019-08-28
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Structural insights into the mechanism of human soluble guanylate cyclase.
Nature, 574, 2019
6JT1
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BU of 6jt1 by Molmil
Structure of human soluble guanylate cyclase in the heme oxidised state
分子名称: Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, PROTOPORPHYRIN IX CONTAINING FE
著者Chen, L, Kang, Y, Liu, R, Wu, J.-X.
登録日2019-04-08
公開日2019-08-28
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Structural insights into the mechanism of human soluble guanylate cyclase.
Nature, 574, 2019
6L72
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BU of 6l72 by Molmil
Sirtuin 2 demyristoylation native final product
分子名称: NAD-dependent protein deacetylase sirtuin-2, ZINC ION, [(2S,3R,4R,5R)-5-[[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-2,4-bis(oxidanyl)oxolan-3-yl] tetradecanoate
著者Chen, L.F.
登録日2019-10-30
公開日2021-03-31
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.501 Å)
主引用文献Sirtuin 2 protein with H3K18 myristoylated peptide
To Be Published
6L71
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Sirtuin 2 demyristoylation native intermediate I & II mixture
分子名称: NAD-dependent protein deacetylase sirtuin-2, NICOTINAMIDE, PRO-ARG-LYS-GLN-LEU-ALA, ...
著者Chen, L.F.
登録日2019-10-30
公開日2021-03-31
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.109 Å)
主引用文献Sirtuin 2 protein with H3K18 myristoylated peptide
To Be Published
7WIG
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BU of 7wig by Molmil
Cryo-EM structure of the L-054,264-bound human SSTR2-Gi1 complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
著者Chen, L, Wang, W, Dong, Y, Shen, D, Guo, J, Qin, J, Zhang, H, Shen, Q, Zhang, Y, Mao, C.
登録日2022-01-03
公開日2022-06-01
最終更新日2022-08-17
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Structures of the endogenous peptide- and selective non-peptide agonist-bound SSTR2 signaling complexes.
Cell Res., 32, 2022
7VSI
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BU of 7vsi by Molmil
Structure of human SGLT2-MAP17 complex bound with empagliflozin
分子名称: (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol, PALMITIC ACID, PDZK1-interacting protein 1, ...
著者Chen, L, Niu, Y, Liu, R.
登録日2021-10-26
公開日2021-12-15
最終更新日2022-02-16
実験手法ELECTRON MICROSCOPY (2.95 Å)
主引用文献Structural basis of inhibition of the human SGLT2-MAP17 glucose transporter.
Nature, 601, 2022
5ZBG
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BU of 5zbg by Molmil
Cryo-EM structure of human TRPC3 at 4.36A resolution
分子名称: Short transient receptor potential channel 3
著者Chen, L, Tang, Q, Guo, W.
登録日2018-02-11
公開日2018-05-09
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (4.36 Å)
主引用文献Structure of the receptor-activated human TRPC6 and TRPC3 ion channels
Cell Res., 28, 2018
5YX9
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BU of 5yx9 by Molmil
Cryo-EM structure of human TRPC6 at 3.8A resolution
分子名称: Short transient receptor potential channel 6
著者Chen, L, Tang, Q, Guo, W.
登録日2017-12-02
公開日2018-05-23
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structure of the receptor-activated human TRPC6 and TRPC3 ion channels.
Cell Res., 28, 2018
8HBE
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BU of 8hbe by Molmil
Structure of human soluble guanylate cyclase in the inactive state at 3.1 angstrom
分子名称: Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, PROTOPORPHYRIN IX CONTAINING FE
著者Chen, L, Liu, R.
登録日2022-10-28
公開日2023-04-19
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献NO binds to the distal site of haem in the fully activated soluble guanylate cyclase.
Nitric Oxide, 134-135, 2023
8HBH
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BU of 8hbh by Molmil
Structure of human soluble guanylate cyclase in the NO-activated state at 3.1 angstrom
分子名称: Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ...
著者Chen, L, Liu, R.
登録日2022-10-28
公開日2023-04-19
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献NO binds to the distal site of haem in the fully activated soluble guanylate cyclase.
Nitric Oxide, 134-135, 2023
8HBF
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BU of 8hbf by Molmil
Structure of human soluble guanylate cyclase in the NO+Rio state at 3.1 angstrom
分子名称: Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ...
著者Chen, L, Liu, R.
登録日2022-10-28
公開日2023-04-19
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献NO binds to the distal site of haem in the fully activated soluble guanylate cyclase.
Nitric Oxide, 134-135, 2023
8HBW
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BU of 8hbw by Molmil
Structure of human UCP1 in the ATP-bound state
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-5'-TRIPHOSPHATE, CARDIOLIPIN, ...
著者Chen, L, Kang, Y.
登録日2022-10-31
公開日2023-06-21
最終更新日2023-08-30
実験手法ELECTRON MICROSCOPY (2.57 Å)
主引用文献Structural basis for the binding of DNP and purine nucleotides onto UCP1.
Nature, 620, 2023
8HBV
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BU of 8hbv by Molmil
Structure of human UCP1 in the nucleotide-free state
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CARDIOLIPIN, Mitochondrial brown fat uncoupling protein 1, ...
著者Chen, L, Kang, Y.
登録日2022-10-31
公開日2023-06-21
最終更新日2023-08-30
実験手法ELECTRON MICROSCOPY (2.51 Å)
主引用文献Structural basis for the binding of DNP and purine nucleotides onto UCP1.
Nature, 620, 2023
5YKF
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BU of 5ykf by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (3D class1 at 4.33A)
分子名称: 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
著者Chen, L, Wu, J.X.
登録日2017-10-14
公開日2018-04-18
最終更新日2019-11-06
実験手法ELECTRON MICROSCOPY (4.33 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
5YKG
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BU of 5ykg by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (Class2 at 4.57A)
分子名称: 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
著者Chen, L, Wu, J.X.
登録日2017-10-14
公開日2018-04-18
最終更新日2018-06-13
実験手法ELECTRON MICROSCOPY (4.57 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
5YKE
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BU of 5yke by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (focused refinement on TM at 4.11A)
分子名称: 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11
著者Chen, L, Wu, J.X.
登録日2017-10-14
公開日2018-04-18
最終更新日2018-06-13
実験手法ELECTRON MICROSCOPY (4.11 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
8J1N
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BU of 8j1n by Molmil
Structure of human UCP1 in the DNP-bound state
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2,4-DINITROPHENOL, CARDIOLIPIN, ...
著者Chen, L, Kang, Y.
登録日2023-04-13
公開日2023-06-21
最終更新日2023-08-30
実験手法ELECTRON MICROSCOPY (2.51 Å)
主引用文献Structural basis for the binding of DNP and purine nucleotides onto UCP1.
Nature, 620, 2023
5YWC
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BU of 5ywc by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with Mg-ADP (CTD class1 at 4.3A)
分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
著者Chen, L, Wu, J.X.
登録日2017-11-29
公開日2018-05-02
最終更新日2018-06-13
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
5YW9
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BU of 5yw9 by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with ATPgammaS (class1 5.0A)
分子名称: ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
著者Chen, L, Wu, J.X.
登録日2017-11-29
公開日2018-05-02
最終更新日2018-06-13
実験手法ELECTRON MICROSCOPY (5 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
5YWB
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BU of 5ywb by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with Mg-ADP (CTD class2 at 5.2A)
分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
著者Chen, L, Wu, J.X.
登録日2017-11-29
公開日2018-05-30
最終更新日2019-11-06
実験手法ELECTRON MICROSCOPY (5.2 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
5YW8
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BU of 5yw8 by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with ATPgammaS (all particles at 4.4A)
分子名称: ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
著者Chen, L, Wu, J.X.
登録日2017-11-29
公開日2018-05-02
最終更新日2018-06-13
実験手法ELECTRON MICROSCOPY (4.4 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
5YWA
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Structure of pancreatic ATP-sensitive potassium channel bound with ATPgammaS (CTD class 2 at 6.1A)
分子名称: ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
著者Chen, L, Wu, J.X.
登録日2017-11-29
公開日2018-05-02
最終更新日2018-06-13
実験手法ELECTRON MICROSCOPY (6.1 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018

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