4I9Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4i9z by Molmil](/molmil-images/mine/4i9z) | Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors | 分子名称: | 5-bromo-2-{5-[(4-methylpiperazin-1-yl)acetyl]-2-propoxyphenyl}-6-(propan-2-yl)pyrimidin-4(3H)-one, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ... | 著者 | Ren, J, Chen, T, Xu, Y. | 登録日 | 2012-12-05 | 公開日 | 2014-01-01 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5. Bioorg.Med.Chem.Lett., 23, 2013
|
|
5CWV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5cwv by Molmil](/molmil-images/mine/5cwv) | Crystal structure of Chaetomium thermophilum Nup192 TAIL domain | 分子名称: | Nucleoporin NUP192 | 著者 | Stuwe, T, Bley, C.J, Thierbach, K, Petrovic, S, Schilbach, S, Mayo, D.J, Perriches, T, Rundlet, E.J, Jeon, Y.E, Collins, L.N, Lin, D.H, Paduch, M, Koide, A, Lu, V, Fischer, J, Hurt, E, Koide, S, Kossiakoff, A.A, Hoelz, A. | 登録日 | 2015-07-28 | 公開日 | 2015-09-16 | 最終更新日 | 2019-12-25 | 実験手法 | X-RAY DIFFRACTION (3.155 Å) | 主引用文献 | Architecture of the fungal nuclear pore inner ring complex. Science, 350, 2015
|
|
5CWW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5cww by Molmil](/molmil-images/mine/5cww) | Crystal structure of the Chaetomium thermophilum heterotrimeric Nup82 NTD-Nup159 TAIL-Nup145N APD complex | 分子名称: | Nucleoporin NUP145N, Nucleoporin NUP159, Nucleoporin NUP82 | 著者 | Stuwe, T, Bley, C.J, Thierbach, K, Petrovic, S, Schilbach, S, Mayo, D.J, Perriches, T, Rundlet, E.J, Jeon, Y.E, Collins, L.N, Lin, D.H, Paduch, M, Koide, A, Lu, V, Fischer, J, Hurt, E, Koide, S, Kossiakoff, A.A, Hoelz, A. | 登録日 | 2015-07-28 | 公開日 | 2015-09-16 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Architecture of the fungal nuclear pore inner ring complex. Science, 350, 2015
|
|
5HNG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5hng by Molmil](/molmil-images/mine/5hng) | DISCOVERY OF NOVEL 7-AZAINDOLES AS PDK1 INHIBITORS | 分子名称: | 3-phosphoinositide-dependent protein kinase 1, 6-methoxy-2-(1H-pyrazol-5-yl)-1H-benzimidazole, SULFATE ION | 著者 | Wucherer-Plietker, M, Esdar, C, Knoechel, T, Hillertz, P, Heinrich, T, Buchstaller, H.P, Greiner, H, Dorsch, D, Calderini, M, Bruge, D, Mueller, T.J.J, Graedler, U. | 登録日 | 2016-01-18 | 公開日 | 2016-06-08 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | 主引用文献 | Discovery of novel 7-azaindoles as PDK1 inhibitors. Bioorg.Med.Chem.Lett., 26, 2016
|
|
5L8V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5l8v by Molmil](/molmil-images/mine/5l8v) | Apo-structure of humanised RadA-mutant humRadA4 | 分子名称: | DNA repair and recombination protein RadA, PHOSPHATE ION | 著者 | Marsh, M, Fischer, G, Moschetti, T, Sharpe, T, Scott, D, Morgan, M, Ng, H, Skidmore, J, Venkitaraman, A, Abell, C, Blundell, T.L, Hyvonen, M. | 登録日 | 2016-06-08 | 公開日 | 2016-10-19 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51. J.Mol.Biol., 428, 2016
|
|
5LB4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5lb4 by Molmil](/molmil-images/mine/5lb4) | Apo-structure of humanised RadA-mutant humRadA14 | 分子名称: | DNA repair and recombination protein RadA | 著者 | Marsh, M, Fischer, G, Moschetti, T, Sharpe, T, Scott, D, Morgan, M, Ng, H, Skidmore, J, Venkitaraman, A, Abell, C, Blundell, T.L, Hyvonen, M. | 登録日 | 2016-06-15 | 公開日 | 2016-10-19 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51. J.Mol.Biol., 428, 2016
|
|
5LBI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5lbi by Molmil](/molmil-images/mine/5lbi) | Apo-structure of humanised RadA-mutant humRadA3 | 分子名称: | CALCIUM ION, DNA repair and recombination protein RadA | 著者 | Marsh, M, Fischer, G, Moschetti, T, Sharpe, T, Scott, D, Morgan, M, Ng, H, Skidmore, J, Venkitaraman, A, Abell, C, Blundell, T.L, Hyvonen, M. | 登録日 | 2016-06-16 | 公開日 | 2016-10-26 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | 主引用文献 | Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51. J.Mol.Biol., 428, 2016
|
|
5HKM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5hkm by Molmil](/molmil-images/mine/5hkm) | DISCOVERY OF NOVEL 7-AZAINDOLES AS PDK1 INHIBITORS | 分子名称: | 3-phosphoinositide-dependent protein kinase 1, 4-ethyl-6-[5-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amine, SULFATE ION | 著者 | Wucherer-Plietker, M, Esdar, C, Knoechel, T, Hillertz, P, Heinrich, T, Buchstaller, H.P, Greiner, H, Dorsch, D, Calderini, M, Bruge, D, Mueller, T.J.J, Graedler, U. | 登録日 | 2016-01-14 | 公開日 | 2016-06-08 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Discovery of novel 7-azaindoles as PDK1 inhibitors. Bioorg.Med.Chem.Lett., 26, 2016
|
|
5XS7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5xs7 by Molmil](/molmil-images/mine/5xs7) | Structure of Coxsackievirus A6 (CVA6) virus A-particle in complex with the neutralizing antibody fragment 1D5 | 分子名称: | Genome polyprotein, Heavy chain of Fab 1D5, Light chain of Fab 1D5 | 著者 | Zheng, Q.B, He, M.Z, Xu, L.F, Yu, H, Li, S.W, Cheng, T. | 登録日 | 2017-06-12 | 公開日 | 2017-09-27 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody Nat Commun, 8, 2017
|
|
6ACU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6acu by Molmil](/molmil-images/mine/6acu) | The structure of CVA10 virus mature virion | 分子名称: | SPHINGOSINE, VP1, VP2, ... | 著者 | Cui, Y.X, Zheng, Q.B, Zhu, R, Xu, L.F, Li, S.W, Yan, X.D, Zhou, Z.H, Cheng, T. | 登録日 | 2018-07-27 | 公開日 | 2018-11-21 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Discovery and structural characterization of a therapeutic antibody against coxsackievirus A10. Sci Adv, 4, 2018
|
|
5HO8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ho8 by Molmil](/molmil-images/mine/5ho8) | DISCOVERY OF NOVEL 7-AZAINDOLES AS PDK1 INHIBITORS | 分子名称: | 3-phosphoinositide-dependent protein kinase 1, 4-butyl-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine, SULFATE ION | 著者 | Wucherer-Plietker, M, Esdar, C, Knoechel, T, Hillertz, P, Heinrich, T, Buchstaller, H.P, Greiner, H, Dorsch, D, Calderini, M, Bruge, D, Mueller, T.J.J, Graedler, U. | 登録日 | 2016-01-19 | 公開日 | 2016-06-08 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Discovery of novel 7-azaindoles as PDK1 inhibitors. Bioorg.Med.Chem.Lett., 26, 2016
|
|
6ACW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6acw by Molmil](/molmil-images/mine/6acw) | The structure of CVA10 virus procapsid particle | 分子名称: | VP0, VP1, VP3 | 著者 | Zhu, R, Xu, L.F, Zheng, Q.B, Cui, Y.X, Li, S.W, Yan, X.D, Zhou, Z.H, Cheng, T. | 登録日 | 2018-07-27 | 公開日 | 2018-11-21 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Discovery and structural characterization of a therapeutic antibody against coxsackievirus A10. Sci Adv, 4, 2018
|
|
6AJ2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6aj2 by Molmil](/molmil-images/mine/6aj2) | The structure of ICAM-5 triggered Enterovirus D68 virus A-particle | 分子名称: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3 | 著者 | Zheng, Q.B, Zhu, R, Xu, L.F, He, M.Z, Yan, X.D, Cheng, T, Li, S.W. | 登録日 | 2018-08-26 | 公開日 | 2018-11-07 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization Nat Microbiol, 4, 2019
|
|
6AD1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ad1 by Molmil](/molmil-images/mine/6ad1) | The structure of CVA10 procapsid from its complex with Fab 2G8 | 分子名称: | VP0, VP1, VP3 | 著者 | Zhu, R, Zheng, Q.B, Xu, L.F, Cui, Y.X, Li, S.W, Yan, X.D, Zhou, Z.H, Cheng, T. | 登録日 | 2018-07-28 | 公開日 | 2018-11-21 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Discovery and structural characterization of a therapeutic antibody against coxsackievirus A10. Sci Adv, 4, 2018
|
|
6AJ0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6aj0 by Molmil](/molmil-images/mine/6aj0) | The structure of Enterovirus D68 mature virion | 分子名称: | Capsid protein VP3, Capsid protein VP4, Viral protein 1, ... | 著者 | Zheng, Q.B, Zhu, R, Xu, L.F, He, M.Z, Yan, X.D, Cheng, T, Li, S.W. | 登録日 | 2018-08-25 | 公開日 | 2018-11-07 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization Nat Microbiol, 4, 2019
|
|
3SIE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3sie by Molmil](/molmil-images/mine/3sie) | |
5FOS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5fos by Molmil](/molmil-images/mine/5fos) | HUMANISED MONOMERIC RADA IN COMPLEX WITH OLIGOMERISATION PEPTIDE | 分子名称: | DNA REPAIR AND RECOMBINATION PROTEIN RADA, GLYCEROL, PHOSPHATE ION | 著者 | Sharpe, T, Moschetti, T, Fischer, G, Marsh, M, Blundell, T.L, Abell, C, Hyvonen, M. | 登録日 | 2015-11-26 | 公開日 | 2016-10-19 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51. J.Mol.Biol., 428, 2016
|
|
4RTH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4rth by Molmil](/molmil-images/mine/4rth) | The crystal structure of PsbP from Zea mays | 分子名称: | Membrane-extrinsic protein of photosystem II PsbP | 著者 | Cao, P, Xie, Y, Li, M, Pan, X.W, Zhang, H.M, Zhao, X.L, Su, X.D, Cheng, T, Chang, W. | 登録日 | 2014-11-15 | 公開日 | 2015-03-11 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystal structure analysis of extrinsic PsbP protein of photosystem II reveals a manganese-induced conformational change. Mol Plant, 8, 2015
|
|
7CN9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7cn9 by Molmil](/molmil-images/mine/7cn9) | Cryo-EM structure of SARS-CoV-2 Spike ectodomain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Ho, M, Chang, Y, Wang, C, Wu, Y, Huang, H, Chen, T, Lo, J.M, Chen, X, Ma, C. | 登録日 | 2020-07-30 | 公開日 | 2020-08-26 | 最終更新日 | 2021-03-10 | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | 主引用文献 | A Carbohydrate-Binding Protein from the Edible Lablab Beans Effectively Blocks the Infections of Influenza Viruses and SARS-CoV-2. Cell Rep, 32, 2020
|
|
4RTI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4rti by Molmil](/molmil-images/mine/4rti) | The crystal structure of PsbP from Spinacia oleracea | 分子名称: | CHLORIDE ION, MANGANESE (II) ION, Oxygen-evolving enhancer protein 2, ... | 著者 | Cao, P, Xie, Y, Li, M, Pan, X.W, Zhang, H.M, Zhao, X.L, Su, X.D, Cheng, T, Chang, W. | 登録日 | 2014-11-15 | 公開日 | 2015-03-11 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure analysis of extrinsic PsbP protein of photosystem II reveals a manganese-induced conformational change. Mol Plant, 8, 2015
|
|
7MVZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7mvz by Molmil](/molmil-images/mine/7mvz) | Single particle cryo-EM structure of the Chaetomium thermophilum Nup188-Nic96-Nup145N complex (Nup188 residues 1-1858; Nic96 residues 240-301; Nup145N residues 640-732) | 分子名称: | Nucleoporin NIC96, Nucleoporin NUP145N, Nucleoporin NUP188 | 著者 | Petrovic, S, Samanta, D, Perriches, T, Bley, C.J, Thierbach, K, Brown, B, Nie, S, Mobbs, G.W, Stevens, T.A, Liu, X, Tomaleri, G.P, Schaus, L, Hoelz, A. | 登録日 | 2021-05-15 | 公開日 | 2022-06-15 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (2.81 Å) | 主引用文献 | Architecture of the linker-scaffold in the nuclear pore. Science, 376, 2022
|
|
7MVW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7mvw by Molmil](/molmil-images/mine/7mvw) | Crystal structure of Chaetomium thermophilum Nup188 NTD (residues 1-1134) | 分子名称: | GLYCEROL, Nucleoporin NUP188 | 著者 | Petrovic, S, Samanta, D, Perriches, T, Bley, C.J, Thierbach, K, Brown, B, Nie, S, Mobbs, G.W, Stevens, T.A, Liu, X, Tomaleri, G.P, Schaus, L, Hoelz, A. | 登録日 | 2021-05-15 | 公開日 | 2022-06-15 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.76 Å) | 主引用文献 | Architecture of the linker-scaffold in the nuclear pore. Science, 376, 2022
|
|
7MVT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7mvt by Molmil](/molmil-images/mine/7mvt) | Crystal structure of the Chaetomium thermophilum Nup192-Nic96 complex (Nup192 residues 185-1756; Nic96 residues 187-301) | 分子名称: | Nucleoporin NIC96, Nucleoporin NUP192 | 著者 | Petrovic, S, Samanta, D, Perriches, T, Bley, C.J, Thierbach, K, Brown, B, Nie, S, Mobbs, G.W, Stevens, T.A, Liu, X, Tomaleri, G.P, Schaus, L, Hoelz, A. | 登録日 | 2021-05-15 | 公開日 | 2022-06-15 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Architecture of the linker-scaffold in the nuclear pore. Science, 376, 2022
|
|
7MVV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7mvv by Molmil](/molmil-images/mine/7mvv) | Single particle cryo-EM structure of the Chaetomium thermophilum Nup192-Nic96-Nup53-Nup145N complex (Nup192 residues 1-1756; Nic96 residues 240-301; Nup53 31-67; Nup145N 616-683) | 分子名称: | Nucleoporin NIC96, Nucleoporin NUP145N, Nucleoporin NUP192, ... | 著者 | Petrovic, S, Samanta, D, Perriches, T, Bley, C.J, Thierbach, K, Brown, B, Nie, S, Mobbs, G.W, Stevens, T.A, Liu, X, Tomaleri, G.P, Schaus, L, Hoelz, A. | 登録日 | 2021-05-15 | 公開日 | 2022-06-15 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | Architecture of the linker-scaffold in the nuclear pore. Science, 376, 2022
|
|
7MVU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7mvu by Molmil](/molmil-images/mine/7mvu) | Single particle cryo-EM structure of the Chaetomium thermophilum Nup192-Nic96 complex (Nup192 residues 1-1756; Nic96 residues 240-301) | 分子名称: | Nucleoporin NIC96, Nucleoporin NUP192 | 著者 | Petrovic, S, Samanta, D, Perriches, T, Bley, C.J, Thierbach, K, Brown, B, Nie, S, Mobbs, G.W, Stevens, T.A, Liu, X, Tomaleri, G.P, Schaus, L, Hoelz, A. | 登録日 | 2021-05-15 | 公開日 | 2022-06-15 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.77 Å) | 主引用文献 | Architecture of the linker-scaffold in the nuclear pore. Science, 376, 2022
|
|