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PDB: 34 件
8KE7
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BU of 8ke7 by Molmil
Crystal structure of DNA binding and cleavage core of human topoisomerase 2-beta in a DNA binding-competent conformation
分子名称: ACETATE ION, DNA topoisomerase 2-beta
著者Chan, N.L, Liu, K.T, Chen, S.F.
登録日2023-08-11
公開日2024-07-24
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural Basis for the Assembly of Type IIA Topoisomerase DNA Cleavage/Religation Center
To Be Published
8W50
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Crystal structure of DNA binding and cleavage core of human topoisomerase 2-alpha in a DNA binding-competent conformation
分子名称: DNA topoisomerase 2-alpha, SULFATE ION
著者Chan, N.L, Liu, K.T, Chen, S.F.
登録日2023-08-25
公開日2024-07-24
実験手法X-RAY DIFFRACTION (2.67 Å)
主引用文献Structural Basis for the Assembly of Type IIA Topoisomerase DNA Cleavage/Religation Center
To Be Published
1RQ4
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BU of 1rq4 by Molmil
Crystallographic Analysis of the Interaction of Nitric Oxide with Quaternary-T Human Hemoglobin, HEMOGLOBIN EXPOSED TO NO UNDER AEROBIC CONDITIONS
分子名称: Hemoglobin alpha chain, Hemoglobin beta chain, NITRIC OXIDE, ...
著者Chan, N.L, Kavanaugh, J.S, Rogers, P.H, Arnone, A.
登録日2003-12-04
公開日2003-12-23
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献Crystallographic analysis of the interaction of nitric oxide with quaternary-T human hemoglobin.
Biochemistry, 43, 2004
1RQ3
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Crystallographic Analysis of the Interaction of Nitric Oxide with Quaternary-T Human Deoxyhemoglobin, Deoxyhemoglobin
分子名称: Hemoglobin alpha chain, Hemoglobin beta chain, PROTOPORPHYRIN IX CONTAINING FE
著者Chan, N.L, Kavanaugh, J.S, Rogers, P.H, Arnone, A.
登録日2003-12-04
公開日2003-12-23
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Crystallographic analysis of the interaction of nitric oxide with quaternary-T human hemoglobin.
Biochemistry, 43, 2004
6L6E
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BU of 6l6e by Molmil
Human PDE5 catalytic core in complex with avanafil
分子名称: 4-[(3-chloranyl-4-methoxy-phenyl)methylamino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-N-(pyrimidin-2-ylmethyl)pyrimid ine-5-carboxamide, MAGNESIUM ION, SULFATE ION, ...
著者Hsieh, C.M, Chan, N.L.
登録日2019-10-28
公開日2020-09-02
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Structure of Human Phosphodiesterase 5A1 Complexed with Avanafil Reveals Molecular Basis of Isoform Selectivity and Guidelines for Targeting alpha-Helix Backbone Oxygen by Halogen Bonding.
J.Med.Chem., 63, 2020
3L6V
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BU of 3l6v by Molmil
Crystal Structure of the Xanthomonas campestris Gyrase A C-terminal Domain
分子名称: DNA gyrase subunit A
著者Hsieh, T.J, Yen, T.J, Lin, T.S, Chang, H.T, Huang, S.Y, Farh, L, Chan, N.L.
登録日2009-12-26
公開日2010-03-09
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献Twisting of the DNA binding surface by a beta-strand-bearing proline modulates DNA gyrase activity
To be Published
4UA2
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BU of 4ua2 by Molmil
Crystal structure of dual function transcriptional regulator MerR from Bacillus megaterium MB1
分子名称: Regulatory protein
著者Lin, L.Y, Chang, C.C, Zou, X.W, Huang, C.C, Chan, N.L.
登録日2014-08-07
公開日2015-07-22
最終更新日2020-01-29
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献Structural basis of the mercury(II)-mediated conformational switching of the dual-function transcriptional regulator MerR
Nucleic Acids Res., 43, 2015
4UA1
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BU of 4ua1 by Molmil
Crystal structure of dual function transcriptional regulator MerR form Bacillus megaterium MB1 in complex with mercury (II) ion
分子名称: MERCURY (II) ION, Regulatory protein
著者Chang, C.C, Lin, L.Y, Zou, X.W, Huang, C.C, Chan, N.L.
登録日2014-08-07
公開日2015-07-22
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.56 Å)
主引用文献Structural basis of the mercury(II)-mediated conformational switching of the dual-function transcriptional regulator MerR
Nucleic Acids Res., 43, 2015
4ZGY
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BU of 4zgy by Molmil
STRUCTURE of HUMAN ORNITHINE DECARBOXYLASE IN COMPLEX WITH A C-TERMINAL FRAGMENT OF ANTIZYME
分子名称: MAGNESIUM ION, Ornithine decarboxylase, Ornithine decarboxylase antizyme 1, ...
著者Wu, H.Y, Chan, N.L.
登録日2015-04-24
公開日2015-09-02
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献Structural basis of antizyme-mediated regulation of polyamine homeostasis
Proc.Natl.Acad.Sci.USA, 112, 2015
4ZGZ
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BU of 4zgz by Molmil
STRUCTURE OF HUMAN ANTIZYME INHIBITOR IN COMPLEX WITH A C-TERMINAL FRAGMENT OF ANTIZYME
分子名称: Antizyme inhibitor 1, Ornithine decarboxylase antizyme 1
著者Chen, S.F, Wu, H.Y, Chan, N.L.
登録日2015-04-24
公開日2015-09-02
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (5.81 Å)
主引用文献Structural basis of antizyme-mediated regulation of polyamine homeostasis
Proc.Natl.Acad.Sci.USA, 112, 2015
2GSC
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BU of 2gsc by Molmil
Crystal Structure of the Conserved Hypothetical Cytosolic Protein Xcc0516 from Xanthomonas campestris
分子名称: Putative uncharacterized protein XCC0516
著者Lin, L.Y, Ching, C.L, Chin, K.H, Chou, S.H, Chan, N.L.
登録日2006-04-26
公開日2006-10-03
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Crystal structure of the conserved hypothetical cytosolic protein Xcc0516 from Xanthomonas campestris reveals a novel quaternary structure assembled by five four-helix bundles.
Proteins, 65, 2006
3QX3
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BU of 3qx3 by Molmil
Human topoisomerase IIbeta in complex with DNA and etoposide
分子名称: (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
著者Wu, C.C, Li, T.K, Farh, L, Lin, L.Y, Lin, T.S, Yu, Y.J, Yen, T.J, Chiang, C.W, Chan, N.L.
登録日2011-03-01
公開日2011-07-06
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.162 Å)
主引用文献Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide
Science, 333, 2011
5GWK
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BU of 5gwk by Molmil
Human topoisomerase IIalpha in complex with DNA and etoposide
分子名称: (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
著者Wang, Y.R, Wu, C.C, Chan, N.L.
登録日2016-09-12
公開日2017-08-23
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3.152 Å)
主引用文献Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry
Nucleic Acids Res., 45, 2017
5H02
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BU of 5h02 by Molmil
Crystal structure of Methanohalophilus portucalensis glycine sarcosine N-methyltransferase tetramutant (H21G, E23T, E24N, L28S)
分子名称: Glycine sarcosine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, TRIMETHYL GLYCINE
著者Lee, Y.R, Lin, T.S, Lai, S.J, Liu, M.S, Lai, M.C, Chan, N.L.
登録日2016-10-02
公開日2016-11-23
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.776 Å)
主引用文献Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity.
Sci Rep, 6, 2016
5GWJ
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BU of 5gwj by Molmil
Structure of a Human topoisomerase IIbeta fragment in complex with DNA and E7873S
分子名称: DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), DNA topoisomerase 2-beta, ...
著者Wang, Y.R, Chen, S.F, Wu, C.C, Chan, N.L.
登録日2016-09-12
公開日2017-08-23
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.566 Å)
主引用文献Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry
Nucleic Acids Res., 45, 2017
5GWX
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BU of 5gwx by Molmil
Crystal structure of glycine sarcosine N-methyltransferase from Methanohalophilus portucalensis in complex with S-adenosylmethionine and sarcosine
分子名称: 1,2-ETHANEDIOL, Glycine sarcosine N-methyltransferase, S-ADENOSYLMETHIONINE, ...
著者Lee, Y.R, Lin, T.S, Lai, S.J, Liu, M.S, Lai, M.C, Chan, N.L.
登録日2016-09-14
公開日2016-11-23
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.205 Å)
主引用文献Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity.
Sci Rep, 6, 2016
5HIL
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BU of 5hil by Molmil
Crystal structure of glycine sarcosine N-methyltransferase from Methanohalophilus portucalensis in complex with S-adenosylhomocysteine and sarcosine
分子名称: 1,2-ETHANEDIOL, Glycine sarcosine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Lee, Y.R, Lin, T.S, Lai, S.J, Liu, M.S, Lai, M.C, Chan, N.L.
登録日2016-01-12
公開日2016-11-23
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.471 Å)
主引用文献Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity
Sci Rep, 6, 2016
5HIM
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BU of 5him by Molmil
Crystal structure of glycine sarcosine N-methyltransferase from Methanohalophilus portucalensis in complex with S-adenosylhomocysteine and dimethylglycine
分子名称: 1,2-ETHANEDIOL, Glycine sarcosine N-methyltransferase, N,N-DIMETHYLGLYCINE, ...
著者Lee, Y.R, Lin, T.S, Lai, S.J, Liu, M.S, Lai, M.C, Chan, N.L.
登録日2016-01-12
公開日2016-11-23
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.338 Å)
主引用文献Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity
Sci Rep, 6, 2016
5ZRF
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Crystal structure of human topoisomerase II beta in complex with 5-iodouridine-containing-DNA and etoposide in space group p21
分子名称: (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA topoisomerase 2-beta, ...
著者Chen, S.F, Wang, Y.R, Wu, C.C, Chan, N.L.
登録日2018-04-24
公開日2018-08-08
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate.
Nat Commun, 9, 2018
5HIK
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BU of 5hik by Molmil
Crystal structure of glycine sarcosine N-methyltransferase from Methanohalophilus portucalensis in complex with S-adenosylmethionine
分子名称: 1,2-ETHANEDIOL, Glycine sarcosine N-methyltransferase, S-ADENOSYLMETHIONINE
著者Lee, Y.R, Lin, T.S, Lai, S.J, Liu, M.S, Lai, M.C, Chan, N.L.
登録日2016-01-12
公開日2016-11-23
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.354 Å)
主引用文献Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity
Sci Rep, 6, 2016
5ZEN
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BU of 5zen by Molmil
Crystal structure of human topoisomerase II beta in complex with DNA: a new quaternary conformation showing opening of the protein-linked DNA-gate
分子名称: DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), DNA topoisomerase 2-beta, ...
著者Chen, S.F, Wang, Y.R, Chan, N.L.
登録日2018-02-27
公開日2018-08-08
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate.
Nat Commun, 9, 2018
5ZQF
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Crystal structure of human topoisomerase II beta in complex with 5-iodouridine-containing-DNA in space group P3221
分子名称: DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA topoisomerase 2-beta, DNA/RNA (5'-D(P*AP*GP*C)-R(P*(IU))-D(P*CP*GP*GP*C)-R(P*(IU))-3'), ...
著者Chen, S.F, Wang, Y.R, Chan, N.L.
登録日2018-04-18
公開日2018-08-08
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.873 Å)
主引用文献Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate.
Nat Commun, 9, 2018
5HIJ
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BU of 5hij by Molmil
Crystal structure of glycine sarcosine N-methyltransferase from Methanohalophilus portucalensis in complex with betaine
分子名称: Glycine sarcosine N-methyltransferase, TRIMETHYL GLYCINE
著者Lee, Y.R, Lin, T.S, Lai, S.J, Liu, M.S, Lai, M.C, Chan, N.L.
登録日2016-01-12
公開日2016-11-23
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity
Sci Rep, 6, 2016
5HII
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BU of 5hii by Molmil
Crystal structure of glycine sarcosine N-methyltransferase (GSMT) from Methanohalophilus portucalensis (apo form)
分子名称: 1,2-ETHANEDIOL, Glycine sarcosine N-methyltransferase
著者Lee, Y.R, Lin, T.S, Lai, S.J, Liu, M.S, Lai, M.C, Chan, N.L.
登録日2016-01-12
公開日2016-11-23
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity
Sci Rep, 6, 2016
5GWI
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BU of 5gwi by Molmil
Structure of a Human topoisomerase IIbeta fragment in complex with DNA and E7873R
分子名称: DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), DNA topoisomerase 2-beta, ...
著者Wang, Y.R, Chen, S.F, Wu, C.C, Chan, N.L.
登録日2016-09-12
公開日2017-08-23
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.737 Å)
主引用文献Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry
Nucleic Acids Res., 45, 2017

 

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