Loading
PDBj
メニューPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 31 件

7YCF
DownloadVisualize
BU of 7ycf by Molmil
HYDROXYNITRILE LYASE FROM THE MILLIPEDE, Oxidus gracilis IN ACETONITRILE
分子名称: 2-HYDROXY-2-METHYLPROPANENITRILE, CHLORIDE ION, Hydroxynitrile lyase, ...
著者Chaikaew, S, Watanabe, Y, Zheng, D, Motojima, F, Asano, Y.
登録日2022-07-01
公開日2024-01-24
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Structure-Based Site-Directed Mutagenesis of Hydroxynitrile Lyase from Cyanogenic Millipede, Oxidus gracilis for Hydrocyanation and Henry Reactions.
Chembiochem, 25, 2024
7YCB
DownloadVisualize
BU of 7ycb by Molmil
HYDROXYNITRILE LYASE FROM THE MILLIPEDE
分子名称: CHLORIDE ION, GLYCEROL, Hydroxynitrile lyase, ...
著者Chaikaew, S, Watanabe, Y, Zheng, D, Motojima, F, Asano, Y.
登録日2022-07-01
公開日2024-01-24
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Structure-Based Site-Directed Mutagenesis of Hydroxynitrile Lyase from Cyanogenic Millipede, Oxidus gracilis for Hydrocyanation and Henry Reactions.
Chembiochem, 25, 2024
7YCT
DownloadVisualize
BU of 7yct by Molmil
HYDROXYNITRILE LYASE FROM THE MILLIPEDE, Oxidus gracilis complexed with (R)-2-Chloromandelonitrile
分子名称: (2~{R})-2-(2-chlorophenyl)-2-oxidanyl-ethanenitrile, GLYCEROL, Hydroxynitrile lyase, ...
著者Chaikaew, S, Watanabe, Y, Zheng, D, Motojima, F, Asano, Y.
登録日2022-07-01
公開日2024-01-24
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Structure-Based Site-Directed Mutagenesis of Hydroxynitrile Lyase from Cyanogenic Millipede, Oxidus gracilis for Hydrocyanation and Henry Reactions.
Chembiochem, 25, 2024
7YCD
DownloadVisualize
BU of 7ycd by Molmil
HYDROXYNITRILE LYASE FROM THE MILLIPEDE, Oxidus gracilis bound with (R)-(+)-ALPHA-HYDROXYBENZENE-ACETONITRILE
分子名称: (2R)-hydroxy(phenyl)ethanenitrile, Hydroxynitrile lyase, SULFATE ION
著者Chaikaew, S, Watanabe, Y, Zheng, D, Motojima, F, Asano, Y.
登録日2022-07-01
公開日2024-01-24
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Structure-Based Site-Directed Mutagenesis of Hydroxynitrile Lyase from Cyanogenic Millipede, Oxidus gracilis for Hydrocyanation and Henry Reactions.
Chembiochem, 25, 2024
7YAX
DownloadVisualize
BU of 7yax by Molmil
HYDROXYNITRILE LYASE FROM THE MILLIPEDE,
分子名称: CHLORIDE ION, Hydroxynitrile lyase, SULFATE ION
著者Chaikaew, S, Watanabe, Y, Zheng, D, Motojima, F, Asano, Y.
登録日2022-06-28
公開日2024-01-17
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Structure-Based Site-Directed Mutagenesis of Hydroxynitrile Lyase from Cyanogenic Millipede, Oxidus gracilis for Hydrocyanation and Henry Reactions.
Chembiochem, 25, 2024
1CW5
DownloadVisualize
BU of 1cw5 by Molmil
SOLUTION STRUCTURE OF CARNOBACTERIOCIN B2
分子名称: TYPE IIA BACTERIOCIN CARNOBACTERIOCIN B2
著者Wang, Y, Henz, M.E, Gallagher, N.L.F, Chai, S, Yan, L.Z, Gibbs, A.C, Stiles, M.E, Wishart, D.S, Vederas, J.C.
登録日1999-08-25
公開日1999-09-07
最終更新日2024-10-30
実験手法SOLUTION NMR
主引用文献Solution structure of carnobacteriocin B2 and implications for structure-activity relationships among type IIa bacteriocins from lactic acid bacteria.
Biochemistry, 38, 1999
1CW6
DownloadVisualize
BU of 1cw6 by Molmil
REFINED SOLUTION STRUCTURE OF LEUCOCIN A
分子名称: TYPE IIA BACTERIOCIN LEUCOCIN A
著者Wang, Y, Henz, M.E, Gallagher, N.L.F, Chai, S, Yan, L.Z, Gibbs, A.C, Stiles, M.E, Wishart, D.S, Vederas, J.C.
登録日1999-08-25
公開日1999-09-08
最終更新日2022-02-16
実験手法SOLUTION NMR
主引用文献Solution structure of carnobacteriocin B2 and implications for structure-activity relationships among type IIa bacteriocins from lactic acid bacteria.
Biochemistry, 38, 1999
5N2M
DownloadVisualize
BU of 5n2m by Molmil
Crystal structure of the first bromodomain of human BRD4 in complex with a tetrahydroquinoline analogue
分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, propan-2-yl ~{N}-[(2~{S},4~{R})-6-(3-acetamidophenyl)-1-ethanoyl-2-methyl-3,4-dihydro-2~{H}-quinolin-4-yl]carbamate
著者Tallant, C, Slavish, P.J, Siejka, P, Bharatham, N, Shadrick, W.R, Chai, S, Young, B.M, Boyd, V.A, Heroven, C, Wiggers, H.J, Picaud, S, Fedorov, O, Krojer, T, Chen, T, Lee, R.E, Guy, R.K, Shelat, A.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
登録日2017-02-07
公開日2018-02-28
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Crystal structure of the first bromodomain of human BRD4 in complex with a tetrahydroquinoline analogue
To Be Published
5N2L
DownloadVisualize
BU of 5n2l by Molmil
Crystal structure of the second bromodomain of human BRD2 in complex with a tetrahydroquinoline analogue
分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 2, SULFATE ION, ...
著者Tallant, C, Slavish, P.J, Siejka, P, Bharatham, N, Shadrick, W.R, Chai, S, Young, B.M, Boyd, V.A, Heroven, C, Wiggers, H.J, Picaud, S, Fedorov, O, Krojer, T, Chen, T, Lee, R.E, Guy, R.K, Shelat, A.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
登録日2017-02-07
公開日2018-02-28
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Crystal structure of the second bromodomain of human BRD2 in complex with a tetrahydroquinoline analogue
To Be Published
5EK9
DownloadVisualize
BU of 5ek9 by Molmil
Crystal structure of the second bromodomain of human BRD2 in complex with a tetrahydroquinoline inhibitor
分子名称: Bromodomain-containing protein 2, propan-2-yl ~{N}-[(2~{S},4~{R})-1-ethanoyl-6-(furan-2-yl)-2-methyl-3,4-dihydro-2~{H}-quinolin-4-yl]carbamate
著者Tallant, C, Slavish, P.J, Siejka, P, Bharatham, N, Shadrick, W.R, Chai, S, Young, B.M, Boyd, V.A, Heroven, C, Picaud, S, Fedorov, O, Chen, T, Lee, R.E, Guy, R.K, Shelat, A.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
登録日2015-11-03
公開日2016-11-16
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors.
Bioorg. Med. Chem., 26, 2018
5X0R
DownloadVisualize
BU of 5x0r by Molmil
Crystal Structure of PXR LBD Complexed with SJB7
分子名称: 4-[(4-tert-butylphenyl)sulfonyl]-1-(2,4-dimethoxy-5-methylphenyl)-5-methyl-1H-1,2,3-triazole, Nuclear receptor coactivator 1, Nuclear receptor subfamily 1 group I member 2
著者Lv, L, Lin, W, Chai, S.C, Zhang, Q, Chen, T.
登録日2017-01-23
公開日2017-10-04
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.665 Å)
主引用文献SPA70 is a potent antagonist of human pregnane X receptor.
Nat Commun, 8, 2017
3D27
DownloadVisualize
BU of 3d27 by Molmil
E. coli methionine aminopeptidase with Fe inhibitor W29
分子名称: 4-(3-ethylthiophen-2-yl)benzene-1,2-diol, MANGANESE (II) ION, Methionine aminopeptidase
著者Ye, Q.Z, Chai, S, He, H.Z.
登録日2008-05-07
公開日2008-08-19
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Discovery of inhibitors of Escherichia coli methionine aminopeptidase with the Fe(II)-form selectivity and antibacterial activity.
J.Med.Chem., 51, 2008
2HJI
DownloadVisualize
BU of 2hji by Molmil
Structural model for the Fe-containing isoform of acireductone dioxygenase
分子名称: E-2/E-2' protein, FE (II) ION
著者Pochapsky, T.C, Ju, T, Maroney, M.J, Chai, S.C.
登録日2006-06-30
公開日2006-10-24
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献One Protein, Two Enzymes Revisited: A Structural Entropy Switch Interconverts the Two Isoforms of Acireductone Dioxygenase
J.Mol.Biol., 363, 2006
9BCA
DownloadVisualize
BU of 9bca by Molmil
Structure of KLHDC2 bound to SJ46411
分子名称: COBALT HEXAMMINE(III), Kelch domain-containing protein 2, N-{[2-(naphthalen-2-yl)-1,3-thiazol-4-yl]acetyl}glycine
著者Scott, D.C, Dharuman, S, Griffith, E, Chai, S.C, Ronnebaum, J, King, M.T, Tangallapally, R, Lee, C, Gee, C.T, Lee, H.W, Ochoada, J, Miller, D.J, Jayasinghe, T, Paulo, J.A, Elledge, S.J, Harper, J.W, Chen, T, Lee, R.E, Schulman, B.A.
登録日2024-04-08
公開日2024-11-06
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Principles of isoform-specific targeted protein degradation engaging the C-degron E3 KLHDC2
To Be Published
9BC9
DownloadVisualize
BU of 9bc9 by Molmil
Structure of KLHDC2 bound to SJ10278
分子名称: COBALT HEXAMMINE(III), Kelch domain-containing protein 2, N-({2-[2-chloro-4-(methoxymethoxy)phenyl]-1,3-thiazol-4-yl}acetyl)glycine
著者Scott, D.C, Dharuman, S, Griffith, E, Chai, S.C, Ronnebaum, J, King, M.T, Tangallapally, R, Lee, C, Gee, C.T, Lee, H.W, Ochoada, J, Miller, D.J, Jayasinghe, T, Paulo, J.A, Elledge, S.J, Harper, J.W, Chen, T, Lee, R.E, Schulman, B.A.
登録日2024-04-08
公開日2024-11-06
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Principles of isoform-specific targeted protein degradation engaging the C-degron E3 KLHDC2
To Be Published
9BCC
DownloadVisualize
BU of 9bcc by Molmil
Structure of KLHDC2 bound to SJ46418
分子名称: COBALT HEXAMMINE(III), Kelch domain-containing protein 2, N-({2-[8-(2-methoxyethoxy)naphthalen-2-yl]-1,3-thiazol-4-yl}acetyl)glycine
著者Scott, D.C, Dharuman, S, Griffith, E, Chai, S.C, Ronnebaum, J, King, M.T, Tangallapally, R, Lee, C, Gee, C.T, Lee, H.W, Ochoada, J, Miller, D.J, Jayasinghe, T, Paulo, J.A, Elledge, S.J, Harper, J.W, Chen, T, Lee, R.E, Schulman, B.A.
登録日2024-04-08
公開日2024-11-06
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Principles of isoform-specific targeted protein degradation engaging the C-degron E3 KLHDC2
To Be Published
4DPD
DownloadVisualize
BU of 4dpd by Molmil
WILD TYPE PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (PfDHFR-TS), DHF COMPLEX, NADP+, dUMP
分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Bifunctional dihydrofolate reductase-thymidylate synthase, DIHYDROFOLIC ACID, ...
著者Yuthavong, Y, Vilaivan, T, Kamchonwongpaisan, S, Charman, S.A, McLennan, D.N, White, K.L, Vivas, L, Bongard, E, Chitnumsub, P, Tarnchompoo, B, Thongphanchang, C, Taweechai, S, Vanichtanakul, J, Arwon, U, Fantauzzi, P, Yuvaniyama, J, Charman, W.N, Matthews, D.
登録日2012-02-13
公開日2012-11-14
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target
Proc.Natl.Acad.Sci.USA, 109, 2012
4DDR
DownloadVisualize
BU of 4ddr by Molmil
Human dihydrofolate reductase complexed with NADPH and P218
分子名称: 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Yuthavong, Y, Tarnchompoo, B, Vilaivan, T, Chitnumsub, P, Kamchonwongpaisan, S, Charman, S.A, McLennan, D.N, White, K.L, Vivas, L, Bongard, E, Thongphanchang, C, Taweechai, S, Vanichtanankul, J, Rattanajak, R, Arwon, U, Fantauzzi, P, Yuvaniyama, J, Charman, W.N, Matthews, D.
登録日2012-01-19
公開日2012-11-14
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target
Proc.Natl.Acad.Sci.USA, 109, 2012
7OFG
DownloadVisualize
BU of 7ofg by Molmil
Oxytocin NMR solution structure
分子名称: Oxytocin
著者Shalev, D.E, Alshanski, I, Yitzchaik, S, Hurevich, M.
登録日2021-05-04
公開日2021-10-13
最終更新日2024-10-16
実験手法SOLUTION NMR
主引用文献Determining the structure and binding mechanism of oxytocin-Cu 2+ complex using paramagnetic relaxation enhancement NMR analysis.
J.Biol.Inorg.Chem., 26, 2021
7OTD
DownloadVisualize
BU of 7otd by Molmil
Oxytocin NMR solution structure
分子名称: AMINO GROUP, COPPER (II) ION, UNK-TYR-ILE-GLN-ASN-CYS-PRO-LEU-GLY
著者Shalev, D.E, Alshanski, I, Yitzchaik, S, Hurevich, M.
登録日2021-06-10
公開日2021-10-13
実験手法SOLUTION NMR
主引用文献Determining the structure and binding mechanism of oxytocin-Cu 2+ complex using paramagnetic relaxation enhancement NMR analysis.
J.Biol.Inorg.Chem., 26, 2021
1JI3
DownloadVisualize
BU of 1ji3 by Molmil
CRYSTAL STRUCTURE OF THE FIRST THERMOSTABLE BACTERIAL LIPASE FROM BACILLUS STEAROTHERMOPHILUS
分子名称: CALCIUM ION, ZINC ION, lipase
著者Tyndall, J.D.A, Sinchaikul, S, Fothergill-Gilmore, L.A, Taylor, P, Walkinshaw, M.D.
登録日2001-06-29
公開日2002-11-01
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal Structure of a Thermostable Lipase from Bacillus stearothermophilus P1
J.Mol.Biol., 323, 2002
4DP3
DownloadVisualize
BU of 4dp3 by Molmil
Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with P218 and NADPH
分子名称: 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, Bifunctional dihydrofolate reductase-thymidylate synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
著者Yuthavong, Y, Vilaivan, T, Kamchonwongpaisan, S, Charman, S.A, McLennan, D.N, White, K.L, Vivas, L, Bongard, E, Chitnumsub, P, Tarnchompoo, B, Thongphanchang, C, Taweechai, S, Vanichtanakul, J, Arwon, U, Fantauzzi, P, Yuvaniyama, J, Charman, W.N, Matthews, D.
登録日2012-02-13
公開日2012-11-14
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target
Proc.Natl.Acad.Sci.USA, 109, 2012
4DPH
DownloadVisualize
BU of 4dph by Molmil
Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with P65 and NADPH
分子名称: 2,4-diamino-6-methyl-5-[3-(2,4,5-trichlorophenoxy)propyloxy]pyrimidine, BETA-MERCAPTOETHANOL, Bifunctional dihydrofolate reductase-thymidylate synthase, ...
著者Yuthavong, Y, Vilaivan, T, Kamchonwongpaisan, S, Charman, S.A, McLennan, D.N, White, K.L, Vivas, L, Bongard, E, Chitnumsub, P, Tarnchompoo, B, Thongphanchang, C, Taweechai, S, Vanichtanakul, J, Arwon, U, Fantauzzi, P, Yuvaniyama, J, Charman, W.N, Matthews, D.
登録日2012-02-13
公開日2012-11-14
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.38 Å)
主引用文献Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target
Proc.Natl.Acad.Sci.USA, 109, 2012
3QFX
DownloadVisualize
BU of 3qfx by Molmil
Trypanosoma brucei dihydrofolate reductase pyrimethamine complex
分子名称: 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE, Bifunctional dihydrofolate reductase-thymidylate synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Vanichtanankul, J, Yuvaniyama, J, Taweechai, S, Chitnumsub, P, Kamchonwongpaisan, S, Yuthavong, Y.
登録日2011-01-24
公開日2011-06-29
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Trypanosomal dihydrofolate reductase reveals natural antifolate resistance
Acs Chem.Biol., 6, 2011
3QG2
DownloadVisualize
BU of 3qg2 by Molmil
Plasmodium falciparum DHFR-TS qradruple mutant (N51I+C59R+S108N+I164L, V1/S) pyrimethamine complex
分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE, Bifunctional dihydrofolate reductase-thymidylate synthase, ...
著者Vanichtanankul, J, Yuvaniyama, J, Taweechai, S, Chitnumsub, P, Kamchonwongpaisan, S, Yuthavong, Y.
登録日2011-01-24
公開日2011-06-29
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Trypanosomal dihydrofolate reductase reveals natural antifolate resistance
Acs Chem.Biol., 6, 2011

 

12>

227111

件を2024-11-06に公開中

PDB statisticsPDBj update infoContact PDBjnumon