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4DPD

WILD TYPE PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (PfDHFR-TS), DHF COMPLEX, NADP+, dUMP

Summary for 4DPD
Entry DOI10.2210/pdb4dpd/pdb
Related1J3I 2QGT 3DGA 4DDR 4DP3 4DPH
DescriptorBifunctional dihydrofolate reductase-thymidylate synthase, DIHYDROFOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
Functional Keywordsdhfr, rossmann fold, reductase, nadph binding, oxidoreductase, transferase
Biological sourcePlasmodium falciparum
Total number of polymer chains2
Total formula weight145459.18
Authors
Primary citationYuthavong, Y.,Tarnchompoo, B.,Vilaivan, T.,Chitnumsub, P.,Kamchonwongpaisan, S.,Charman, S.A.,McLennan, D.N.,White, K.L.,Vivas, L.,Bongard, E.,Thongphanchang, C.,Taweechai, S.,Vanichtanankul, J.,Rattanajak, R.,Arwon, U.,Fantauzzi, P.,Yuvaniyama, J.,Charman, W.N.,Matthews, D.
Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target
Proc.Natl.Acad.Sci.USA, 109:16823-16828, 2012
Cited by
PubMed: 23035243
DOI: 10.1073/pnas.1204556109
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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