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4DPD

WILD TYPE PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (PfDHFR-TS), DHF COMPLEX, NADP+, dUMP

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003824molecular_functioncatalytic activity
A0004146molecular_functiondihydrofolate reductase activity
A0004799molecular_functionthymidylate synthase activity
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0006231biological_processdTMP biosynthetic process
A0006730biological_processone-carbon metabolic process
A0008152biological_processmetabolic process
A0008168molecular_functionmethyltransferase activity
A0009165biological_processnucleotide biosynthetic process
A0016491molecular_functionoxidoreductase activity
A0016740molecular_functiontransferase activity
A0016741molecular_functiontransferase activity, transferring one-carbon groups
A0032259biological_processmethylation
A0046654biological_processtetrahydrofolate biosynthetic process
B0000166molecular_functionnucleotide binding
B0003824molecular_functioncatalytic activity
B0004146molecular_functiondihydrofolate reductase activity
B0004799molecular_functionthymidylate synthase activity
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0006231biological_processdTMP biosynthetic process
B0006730biological_processone-carbon metabolic process
B0008152biological_processmetabolic process
B0008168molecular_functionmethyltransferase activity
B0009165biological_processnucleotide biosynthetic process
B0016491molecular_functionoxidoreductase activity
B0016740molecular_functiontransferase activity
B0016741molecular_functiontransferase activity, transferring one-carbon groups
B0032259biological_processmethylation
B0046654biological_processtetrahydrofolate biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE DHF A 701
ChainResidue
ACYS15
AALA16
AASP54
APHE58
APHE116
AARG122
AILE164
ANAP702
AHOH828

site_idAC2
Number of Residues27
DetailsBINDING SITE FOR RESIDUE NAP A 702
ChainResidue
ACYS15
AALA16
ALEU40
AGLY41
AGLY44
AVAL45
ALEU46
AGLY105
AARG106
ATHR107
ASER108
ALEU127
ASER128
AARG129
ATHR130
AASN144
AILE164
AGLY165
AGLY166
ASER167
AVAL168
AVAL169
ATYR170
AGLU172
ADHF701
AHOH981
AHOH987

site_idAC3
Number of Residues13
DetailsBINDING SITE FOR RESIDUE UMP A 703
ChainResidue
AARG345
ACYS490
AHIS491
AGLN509
AARG510
ASER511
AASP513
AASN521
AHIS551
ATYR553
AHOH870
BARG470
BARG471

site_idAC4
Number of Residues13
DetailsBINDING SITE FOR RESIDUE UMP B 701
ChainResidue
AARG470
AARG471
BARG345
BCYS490
BHIS491
BGLN509
BARG510
BSER511
BASP513
BASN521
BHIS551
BTYR553
BHOH807

Functional Information from PROSITE/UniProt
site_idPS00075
Number of Residues24
DetailsDHFR_1 Dihydrofolate reductase (DHFR) domain signature. GLGnkgvLPWkcnslDmkyFcavT
ChainResidueDetails
AGLY39-THR62

site_idPS00091
Number of Residues29
DetailsTHYMIDYLATE_SYNTHASE Thymidylate synthase active site. RriLlcaWNvkdldqma.....LpPCHilcQFyV
ChainResidueDetails
AARG470-VAL498

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PDB entries from 2024-04-24

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