4DPD
WILD TYPE PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (PfDHFR-TS), DHF COMPLEX, NADP+, dUMP
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004146 | molecular_function | dihydrofolate reductase activity |
A | 0004799 | molecular_function | thymidylate synthase activity |
A | 0005739 | cellular_component | mitochondrion |
A | 0005829 | cellular_component | cytosol |
A | 0006231 | biological_process | dTMP biosynthetic process |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0008168 | molecular_function | methyltransferase activity |
A | 0009165 | biological_process | nucleotide biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
A | 0032259 | biological_process | methylation |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
B | 0000166 | molecular_function | nucleotide binding |
B | 0004146 | molecular_function | dihydrofolate reductase activity |
B | 0004799 | molecular_function | thymidylate synthase activity |
B | 0005739 | cellular_component | mitochondrion |
B | 0005829 | cellular_component | cytosol |
B | 0006231 | biological_process | dTMP biosynthetic process |
B | 0006730 | biological_process | one-carbon metabolic process |
B | 0008168 | molecular_function | methyltransferase activity |
B | 0009165 | biological_process | nucleotide biosynthetic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
B | 0032259 | biological_process | methylation |
B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE DHF A 701 |
Chain | Residue |
A | CYS15 |
A | ALA16 |
A | ASP54 |
A | PHE58 |
A | PHE116 |
A | ARG122 |
A | ILE164 |
A | NAP702 |
A | HOH828 |
site_id | AC2 |
Number of Residues | 27 |
Details | BINDING SITE FOR RESIDUE NAP A 702 |
Chain | Residue |
A | CYS15 |
A | ALA16 |
A | LEU40 |
A | GLY41 |
A | GLY44 |
A | VAL45 |
A | LEU46 |
A | GLY105 |
A | ARG106 |
A | THR107 |
A | SER108 |
A | LEU127 |
A | SER128 |
A | ARG129 |
A | THR130 |
A | ASN144 |
A | ILE164 |
A | GLY165 |
A | GLY166 |
A | SER167 |
A | VAL168 |
A | VAL169 |
A | TYR170 |
A | GLU172 |
A | DHF701 |
A | HOH981 |
A | HOH987 |
site_id | AC3 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE UMP A 703 |
Chain | Residue |
A | ARG345 |
A | CYS490 |
A | HIS491 |
A | GLN509 |
A | ARG510 |
A | SER511 |
A | ASP513 |
A | ASN521 |
A | HIS551 |
A | TYR553 |
A | HOH870 |
B | ARG470 |
B | ARG471 |
site_id | AC4 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE UMP B 701 |
Chain | Residue |
A | ARG470 |
A | ARG471 |
B | ARG345 |
B | CYS490 |
B | HIS491 |
B | GLN509 |
B | ARG510 |
B | SER511 |
B | ASP513 |
B | ASN521 |
B | HIS551 |
B | TYR553 |
B | HOH807 |
Functional Information from PROSITE/UniProt
site_id | PS00075 |
Number of Residues | 24 |
Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. GLGnkgvLPWkcnslDmkyFcavT |
Chain | Residue | Details |
A | GLY39-THR62 |
site_id | PS00091 |
Number of Residues | 29 |
Details | THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RriLlcaWNvkdldqma.....LpPCHilcQFyV |
Chain | Residue | Details |
A | ARG470-VAL498 |