4DP3

Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with P218 and NADPH

Summary for 4DP3

• Entry DOI: 10.2210/pdb4dp3/pdb
• Related: 1J3K 2JSU 3QG2 4DDR 4DPD 4DPH
• Descriptor: Bifunctional dihydrofolate reductase-thymidylate synthase, 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
• Functional Keywords: rossmann fold, reductase, oxidoreductase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Plasmodium falciparum
• Total number of polymer chains: 2
• Total formula weight: 146217.87

Authors

Yuthavong, Y.,Vilaivan, T.,Kamchonwongpaisan, S.,Charman, S.A.,McLennan, D.N.,White, K.L.,Vivas, L.,Bongard, E.,Chitnumsub, P.,Tarnchompoo, B.,Thongphanchang, C.,Taweechai, S.,Vanichtanakul, J.,Arwon, U.,Fantauzzi, P.,Yuvaniyama, J.,Charman, W.N.,Matthews, D. (deposition date: 2012-02-13, release date: 2012-11-14, Last modification date: 2023-11-08)

• Primary citation: Yuthavong, Y.,Tarnchompoo, B.,Vilaivan, T.,Chitnumsub, P.,Kamchonwongpaisan, S.,Charman, S.A.,McLennan, D.N.,White, K.L.,Vivas, L.,Bongard, E.,Thongphanchang, C.,Taweechai, S.,Vanichtanankul, J.,Rattanajak, R.,Arwon, U.,Fantauzzi, P.,Yuvaniyama, J.,Charman, W.N.,Matthews, D.; Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target; Proc.Natl.Acad.Sci.USA, 109:16823-16828, 2012; PubMed: 23035243; DOI: 10.1073/pnas.1204556109

Experimental method

X-RAY DIFFRACTION (2.4 Å)