4DP3
Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with P218 and NADPH
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Bifunctional dihydrofolate reductase-thymidylate synthase | polymer | 608 | 71908.1 | 2 | UniProt (D9N170) Pfam (PF00186) Pfam (PF00303) In PDB | Plasmodium falciparum | |
| 2 | A, B | 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid | non-polymer | 360.4 | 2 | Chemie (MMV) | |||
| 3 | A, B | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
| 4 | A, B | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 5 | water | water | 18.0 | 441 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 143816.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2401.6 | |
| All* | Total formula weight | 146217.9 |
