5LFX
 
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5LFS
 | | Lambda-[Ru(bpy)2(dppz)]2+ bound to brominated DNA | | Descriptor: | BARIUM ION, CHLORIDE ION, DNA (5'-D(*(CBR)P*GP*GP*C)-3'), ... | | Authors: | Hall, J.P, Cardin, C.J. | | Deposit date: | 2016-07-04 | | Release date: | 2017-02-15 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Guanine Can Direct Binding Specificity of Ru-dipyridophenazine (dppz) Complexes to DNA through Steric Effects.
Chemistry, 23, 2017
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5LFW
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5IU5
 | | Lambda-[Ru(TAP)2(dppz)]2+ bound to d(TCGGCICCGA)2 | | Descriptor: | BARIUM ION, DNA (5'-D(*TP*CP*GP*GP*CP*IP*CP*CP*GP*A)-3'), Ru(tap)2(dppz) complex | | Authors: | Hall, J.P, Cardin, C.J. | | Deposit date: | 2016-03-17 | | Release date: | 2017-06-21 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Unexpected enhancement of sensitised photo-oxidation by a Ru(II) complex on replacement of guanine with inosine in DNA
To Be Published
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5IWJ
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5ET2
 | | Lambda-Ru(TAP)2(dppz)]2+ bound to d(TTGGCGCCAA) | | Descriptor: | BARIUM ION, DNA (5'-D(*(THM)P*TP*GP*GP*CP*GP*CP*CP*AP*A)-3'), Ru(tap)2(dppz) complex | | Authors: | Hall, J.P, Cardin, C.J. | | Deposit date: | 2015-11-17 | | Release date: | 2016-11-23 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.39 Å) | | Cite: | Inosine Can Increase DNA's Susceptibility to Photo-oxidation by a Ru(II) Complex due to Structural Change in the Minor Groove.
Chemistry, 23, 2017
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8CMM
 | | Re-pairing DNA - binding of a ruthenium phi complex to a double mismatch | | Descriptor: | DNA (5'-D(*CP*GP*CP*TP*AP*TP*AP*AP*TP*GP*CP*G)-3'), LITHIUM ION, POTASSIUM ION, ... | | Authors: | Prieto Otoya, T.D, Cardin, C.J, McQuaid, K.M. | | Deposit date: | 2023-02-20 | | Release date: | 2024-03-06 | | Last modified: | 2024-07-03 | | Method: | X-RAY DIFFRACTION (0.9 Å) | | Cite: | Re-pairing DNA: binding of a ruthenium phi complex to a double mismatch.
Chem Sci, 15, 2024
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5IP8
 | | Lambda-Ru(TAP)2dppz bound to d(CCGGCTCCGG) | | Descriptor: | BARIUM ION, DNA (5'-D(*CP*CP*GP*GP*AP*GP*CP*CP*GP*G)-3'), DNA (5'-D(*CP*CP*GP*GP*CP*TP*CP*CP*GP*G)-3'), ... | | Authors: | Souter, J.E, Hall, J.P, Cardin, C.J. | | Deposit date: | 2016-03-09 | | Release date: | 2017-03-29 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | Sequence specific binding of light activated Ru-polypyridyls
To Be Published
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4E8S
 | | Lambda-[Ru(TAP)2(dppz{Me2}2)]2+ bound to TCGGCGCCGA at high resolution | | Descriptor: | (11,12-dimethyldipyrido[3,2-a:2',3'-c]phenazine-kappa~2~N~4~,N~5~)[bis(pyrazino[2,3-f]quinoxaline-kappa~2~N~1~,N~10~)]ruthenium(2+), 5'-D(*TP*CP*GP*GP*CP*GP*CP*CP*GP*A)-3', BARIUM ION, ... | | Authors: | Hall, J.P, Cardin, C.J. | | Deposit date: | 2012-03-20 | | Release date: | 2013-03-20 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.24 Å) | | Cite: | The Structural Effect of Methyl Substitution on the Binding of Polypyridyl Ru dppz Complexes to DNA
Organometallics, 2015
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6R6D
 | | [Ru(TAP)2(11,12-CN2-dppz)]2+ bound to d(TCGGCGCCGA)2 | | Descriptor: | BARIUM ION, DNA (5'-D(*TP*CP*GP*GP*CP*GP*CP*CP*GP*A)-3'), Ruthenium (bis-(tetraazaphenanthrene)) (11,12-dicyano-dipyridophenazine), ... | | Authors: | McQuaid, K.T, Hall, J.P, Cardin, C.J. | | Deposit date: | 2019-03-27 | | Release date: | 2020-05-06 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (1.838 Å) | | Cite: | X-ray Crystal Structures Show DNA Stacking Advantage of Terminal Nitrile Substitution in Ru-dppz Complexes.
Chemistry, 24, 2018
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6RNL
 | | L-[Ru(TAP)2(dppz)]2+ bound to the G-quadruplex forming sequence d(TAGGGTT) | | Descriptor: | DNA (5'-D(*TP*AP*GP*GP*GP*TP*T)-3'), POTASSIUM ION, Ru(tap)2(dppz) complex, ... | | Authors: | McQuaid, K.T, Hall, J.P, Cardin, C.J. | | Deposit date: | 2019-05-09 | | Release date: | 2019-08-28 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Three thymine/adenine binding modes of the ruthenium complex Lambda-[Ru(TAP)2(dppz)]2+to the G-quadruplex forming sequence d(TAGGGTT) shown by X-ray crystallography.
Chem.Commun.(Camb.), 55, 2019
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452D
 | | ACRIDINE BINDING TO DNA | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 9-AMINO-(N-(2-DIMETHYLAMINO)ETHYL)ACRIDINE-4-CARBOXAMIDE, DNA (5'-D(*CP*GP*TP*AP*CP*G)-3') | | Authors: | Thorpe, J.H, Todd, A.K, Cardin, C.J. | | Deposit date: | 1999-02-18 | | Release date: | 2003-03-04 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethlyamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5Br-U)ACG)2 at 1.3-angstrom resolution
J.Med.Chem., 42, 1999
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4RE7
 | | Lambda-[Ru(TAP)2(dppz)]2+ bound to d(TCIGCGCCGA) | | Descriptor: | 5'-D(*TP*CP*IP*GP*CP*GP*CP*CP*GP*A)-3', BARIUM ION, Ru(tap)2(dppz) complex | | Authors: | Hall, J.P, Cardin, C.J. | | Deposit date: | 2014-09-22 | | Release date: | 2015-09-30 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.181 Å) | | Cite: | The effects of DNA modification on the binding of polypyridyl ruthenium complexes
To be Published
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4R8J
 | | d(TCGGCGCCGA) with lambda-[Ru(TAP)2(dppz)]2+ soaked in D2O | | Descriptor: | BARIUM ION, CHLORIDE ION, DNA (5'-D(*(THM)P*CP*GP*GP*CP*GP*CP*CP*GP*A)-3'), ... | | Authors: | Hall, J.P, Gurung, S.P, Winter, G.W, Cardin, C.J. | | Deposit date: | 2014-09-02 | | Release date: | 2015-10-28 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.21 Å) | | Cite: | Monitoring one-electron photo-oxidation of guanine in DNA crystals using ultrafast infrared spectroscopy.
Nat Chem, 7, 2015
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243D
 | | STRUCTURE OF THE DNA OCTANUCLEOTIDE D(ACGTACGT)2 | | Descriptor: | DNA (5'-D(*AP*CP*GP*TP*AP*CP*GP*T)-3') | | Authors: | Wilcock, D.J, Adams, A, Cardin, C.J, Wakelin, L.P.G. | | Deposit date: | 1996-01-10 | | Release date: | 1996-02-26 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure of the DNA octanucleotide d(ACGTACGT)2.
Acta Crystallogr.,Sect.D, 52, 1996
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1K2L
 | | STRUCTURAL CHARACTERIZATION OF BISINTERCALATION IN HIGHER-ORDER DNA AT A JUNCTION-LIKE QUADRUPLEX | | Descriptor: | 5'-D(*CP*GP*TP*AP*CP*G)-3', BIS-(9-OCTYLAMINO(2-DIMETHYLAMINOETHYL)ACRIDINE-4-CARBOXAMIDE, COBALT (II) ION | | Authors: | Teixeira, S.C.M, Thorpe, J.H, Todd, A.K, Powell, H.R, Adams, A, Wakelin, L.P.G, Denny, W.A, Cardin, C.J. | | Deposit date: | 2001-09-28 | | Release date: | 2002-10-16 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural Characterisation of Bisintercalation in Higher-order DNA at a Junction-like Quadruplex
J.MOL.BIOL., 323, 2002
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1JUC
 | | Crystal Structure Analysis of a Holliday Junction Formed by CCGGTACCGG | | Descriptor: | 5'-D(*CP*CP*GP*GP*TP*AP*CP*CP*GP*G)-3' | | Authors: | Thorpe, J.H, Teixeira, S.C.M, Gale, B.C, Cardin, C.J. | | Deposit date: | 2001-08-24 | | Release date: | 2002-02-22 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Structural characterization of a new crystal form of the four-way Holliday junction formed by the DNA sequence d(CCGGTACCGG)2: sequence versus lattice?
Acta Crystallogr.,Sect.D, 58, 2002
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1L4J
 | | Holliday Junction TCGGTACCGA with Na and Ca Binding Sites. | | Descriptor: | 5'-D(*TP*CP*GP*GP*TP*AP*CP*CP*GP*A)-3', CALCIUM ION, SODIUM ION | | Authors: | Thorpe, J.H, Gale, B.C, Teixeira, S.C.M, Cardin, C.J. | | Deposit date: | 2002-03-05 | | Release date: | 2003-03-04 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Conformational and Hydration Effects of Site-selective Sodium, Calcium and
Strontium Ion Binding to the DNA Holliday Junction Structure
d(TCGGTACCGA)4
J.Mol.Biol., 327, 2003
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3PBX
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2GJB
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367D
 | | 1.2 A STRUCTURE DETERMINATION OF THE D(CG(5-BRU)ACG)2/5-BROMO-9-AMINO-DACA COMPLEX | | Descriptor: | 5'-D(*CP*GP*(BRU)P*AP*CP*G)-3', 5-BROMO-9-AMINO-N-ETHYL(DIAMINOMETHYL)ACRIDINE-4-CARBOXAMIDE, BROMIDE ION | | Authors: | Todd, A.K, Adams, A, Thorpe, J.H, Denny, W.A, Cardin, C.J. | | Deposit date: | 1997-12-19 | | Release date: | 2003-03-04 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethlyamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5Br-U)ACG)2 at 1.3-angstrom resolution
J.Med.Chem., 42, 1999
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344D
 | | DETERMINATION BY MAD-DM OF THE STRUCTURE OF THE DNA DUPLEX D(ACGTACG(5-BRU))2 AT 1.46A AND 100K | | Descriptor: | DNA (5'-D(*AP*CP*GP*TP*AP*CP*GP*(BRU))-3') | | Authors: | Todd, A.R, Adams, A, Powell, H.R, Cardin, C.J. | | Deposit date: | 1997-08-04 | | Release date: | 1997-09-26 | | Last modified: | 2023-08-02 | | Method: | X-RAY DIFFRACTION (1.46 Å) | | Cite: | Determination by MAD-DM of the structure of the DNA duplex d[ACGTACG(5-BrU)]2 at 1.46 A and 100 K.
Acta Crystallogr.,Sect.D, 55, 1999
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366D
 | | 1.3 A STRUCTURE DETERMINATION OF THE D(CG(5-BRU)ACG)2/6-BROMO-9-AMINO-DACA COMPLEX | | Descriptor: | 6-BROMO-9-AMINO-N-ETHYL(DIAMINOMETHYL)ACRIDINE-4-CARBOXAMIDE, DNA (5'-D(*CP*GP*(BRU)P*AP*CP*G)-3') | | Authors: | Todd, A.K, Adams, A, Thorpe, J.H, Denny, W.A, Cardin, C.J. | | Deposit date: | 1997-12-19 | | Release date: | 1999-04-06 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethylamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5-BrU)ACG)2 at 1.3-A resolution.
J.Med.Chem., 42, 1999
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2GB9
 | | d(CGTACG)2 crosslinked bis-acridine complex | | Descriptor: | 5'-D(*CP*GP*TP*AP*CP*G)-3', 9,9'-(HEXANE-1,6-DIYLDIIMINO)BIS{N-[2-(DIMETHYLAMINO)ETHYL]ACRIDINE-4-CARBOXAMIDE}, STRONTIUM ION | | Authors: | Hopcroft, N.H, Brogden, A.L, Searcey, M, Cardin, C.J. | | Deposit date: | 2006-03-10 | | Release date: | 2006-04-25 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | X-ray crystallographic study of DNA duplex cross-linking: simultaneous binding to two d(CGTACG)2 molecules by a bis(9-aminoacridine-4-carboxamide) derivative.
Nucleic Acids Res., 34, 2006
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2GWA
 | | Crystal Structure of a Complex Formed Between the DNA Holliday Junction and a Bis-Acridine Molecule. | | Descriptor: | 5'-D(*Tp*Cp*Gp*Gp*Tp*Ap*Cp*Cp*Gp*A)-3', 9,9'-(HEXANE-1,6-DIYLDIIMINO)BIS{N-[2-(DIMETHYLAMINO)ETHYL]ACRIDINE-4-CARBOXAMIDE}, SPERMINE | | Authors: | Brogden, A.L, Hopcroft, N.H, Cardin, C.J, Searcey, M. | | Deposit date: | 2006-05-04 | | Release date: | 2006-06-06 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Ligand bridging of the DNA Holliday junction: molecular recognition of a stacked-X four-way junction by a small molecule.
Angew.Chem.Int.Ed.Engl., 46, 2007
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