366D

1.3 A STRUCTURE DETERMINATION OF THE D(CG(5-BRU)ACG)2/6-BROMO-9-AMINO-DACA COMPLEX

Summary for 366D

DescriptorDNA (5'-D(*CP*GP*(BRU)P*AP*CP*G)-3'), 6-BROMO-9-AMINO-N-ETHYL(DIAMINOMETHYL)ACRIDINE-4-CARBOXAMIDE (3 entities in total)
Functional Keywordsdna, drug intercalation, major groove binding
Total number of polymer chains1
Total molecular weight2652.67
Authors
Todd, A.K.,Adams, A.,Thorpe, J.H.,Denny, W.A.,Cardin, C.J. (deposition date: 1997-12-19, release date: 1999-04-06, Last modification date: 2011-07-13)
Primary citation
Todd, A.K.,Adams, A.,Thorpe, J.H.,Denny, W.A.,Wakelin, L.P.,Cardin, C.J.
Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethylamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5-BrU)ACG)2 at 1.3-A resolution.
J.Med.Chem., 42:536-540, 1999
PubMed: 10052960 (PDB entries with the same primary citation)
DOI: 10.1021/jm980479u
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.3 Å)
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Structure validation

ClashscoreRSRZ outliers130MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (366d.pdb1.gz [24.15 KB])