367D

1.2 A STRUCTURE DETERMINATION OF THE D(CG(5-BRU)ACG)2/5-BROMO-9-AMINO-DACA COMPLEX

Summary for 367D

• Entry DOI: 10.2210/pdb367d/pdb
• Descriptor: 5'-D(*CP*GP*(BRU)P*AP*CP*G)-3', 5-BROMO-9-AMINO-N-ETHYL(DIAMINOMETHYL)ACRIDINE-4-CARBOXAMIDE, BROMIDE ION, ... (4 entities in total)
• Functional Keywords: dna, double helix, complexed with drug, modified
• Total number of polymer chains: 2
• Total formula weight: 4918.06

Authors

Todd, A.K.,Adams, A.,Thorpe, J.H.,Denny, W.A.,Cardin, C.J. (deposition date: 1997-12-19, release date: 2003-03-04, Last modification date: 2023-12-27)

• Primary citation: Todd, A.K.,Adams, A.,Thorpe, J.H.,Denny, W.A.,Wakelin, L.P.G.,Cardin, C.J.; Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethlyamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5Br-U)ACG)2 at 1.3-angstrom resolution; J.Med.Chem., 42:536-540, 1999; PubMed: 10052960; DOI: 10.1021/jm980479u

Experimental method

X-RAY DIFFRACTION (1.2 Å)